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TRPV1
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  • TRPV1
PROTEIN STRUCTURE
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

TRPV1
Synonyms VR1
Gene descriptioni

Full gene name according to HGNC.

Transient receptor potential cation channel subfamily V member 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
FDA approved drug targets
Transporters
Voltage-gated ion channels
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 17
Cytoband p13.2
Chromosome location (bp) 3565444 - 3609411
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

7
Ensembl ENSG00000196689 (version 103.38)
Entrez gene 7442
HGNC HGNC:12716
UniProt Q8NER1 (UniProt - Evidence at protein level)
neXtProt NX_Q8NER1
Antibodypedia TRPV1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 626

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
TRPV1-201
TRPV1-202
TRPV1-203
TRPV1-204
TRPV1-206
TRPV1-207
TRPV1-209


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
TRPV1-201
ENSP00000311692
ENST00000310522
E7ESJ2 [Direct mapping]
Osm-9-like TRP channel 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0000166 [nucleotide binding]
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032591 [dendritic spine membrane]
GO:0034220 [ion transmembrane transport]
GO:0045211 [postsynaptic membrane]
GO:0055085 [transmembrane transport]
Show all
779 aa
88.1 kDa
No 6
TRPV1-202
ENSP00000382659
ENST00000399756
Q8NER1 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005216 [ion channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005231 [excitatory extracellular ligand-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007635 [chemosensory behavior]
GO:0015278 [calcium-release channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032591 [dendritic spine membrane]
GO:0034605 [cellular response to heat]
GO:0035091 [phosphatidylinositol binding]
GO:0042995 [cell projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0050955 [thermoception]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051219 [phosphoprotein binding]
GO:0051289 [protein homotetramerization]
GO:0055085 [transmembrane transport]
GO:0060079 [excitatory postsynaptic potential]
GO:0070588 [calcium ion transmembrane transport]
GO:0071312 [cellular response to alkaloid]
GO:0071318 [cellular response to ATP]
GO:0071468 [cellular response to acidic pH]
GO:0098703 [calcium ion import across plasma membrane]
GO:1901594 [response to capsazepine]
Show all
839 aa
95 kDa
No 6
TRPV1-203
ENSP00000382661
ENST00000399759
Q8NER1 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005216 [ion channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005231 [excitatory extracellular ligand-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007635 [chemosensory behavior]
GO:0015278 [calcium-release channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032591 [dendritic spine membrane]
GO:0034605 [cellular response to heat]
GO:0035091 [phosphatidylinositol binding]
GO:0042995 [cell projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0050955 [thermoception]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051219 [phosphoprotein binding]
GO:0051289 [protein homotetramerization]
GO:0055085 [transmembrane transport]
GO:0060079 [excitatory postsynaptic potential]
GO:0070588 [calcium ion transmembrane transport]
GO:0071312 [cellular response to alkaloid]
GO:0071318 [cellular response to ATP]
GO:0071468 [cellular response to acidic pH]
GO:0098703 [calcium ion import across plasma membrane]
GO:1901594 [response to capsazepine]
Show all
839 aa
95 kDa
No 6
TRPV1-204
ENSP00000409627
ENST00000425167
E7EQ78 [Direct mapping]
Osm-9-like TRP channel 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001659 [temperature homeostasis]
GO:0001660 [fever generation]
GO:0001774 [microglial cell activation]
GO:0002024 [diet induced thermogenesis]
GO:0002790 [peptide secretion]
GO:0003085 [negative regulation of systemic arterial blood pressure]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005216 [ion channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005231 [excitatory extracellular ligand-gated ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008324 [cation transmembrane transporter activity]
GO:0009268 [response to pH]
GO:0009408 [response to heat]
GO:0009897 [external side of plasma membrane]
GO:0010243 [response to organonitrogen compound]
GO:0010459 [negative regulation of heart rate]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0014047 [glutamate secretion]
GO:0014832 [urinary bladder smooth muscle contraction]
GO:0015276 [ligand-gated ion channel activity]
GO:0015278 [calcium-release channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017081 [chloride channel regulator activity]
GO:0019233 [sensory perception of pain]
GO:0030425 [dendrite]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032591 [dendritic spine membrane]
GO:0034220 [ion transmembrane transport]
GO:0034605 [cellular response to heat]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043434 [response to peptide hormone]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048265 [response to pain]
GO:0048266 [behavioral response to pain]
GO:0050954 [sensory perception of mechanical stimulus]
GO:0050960 [detection of temperature stimulus involved in thermoception]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050968 [detection of chemical stimulus involved in sensory perception of pain]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051289 [protein homotetramerization]
GO:0055085 [transmembrane transport]
GO:0060079 [excitatory postsynaptic potential]
GO:0060083 [smooth muscle contraction involved in micturition]
GO:0060454 [positive regulation of gastric acid secretion]
GO:0070588 [calcium ion transmembrane transport]
GO:0071312 [cellular response to alkaloid]
GO:0071318 [cellular response to ATP]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071468 [cellular response to acidic pH]
GO:0071502 [cellular response to temperature stimulus]
GO:0090212 [negative regulation of establishment of blood-brain barrier]
GO:0097603 [temperature-gated ion channel activity]
GO:0098703 [calcium ion import across plasma membrane]
GO:1901594 [response to capsazepine]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
850 aa
96.1 kDa
No 6
TRPV1-206
ENSP00000461007
ENST00000571088
Q8NER1 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005216 [ion channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005231 [excitatory extracellular ligand-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007635 [chemosensory behavior]
GO:0015278 [calcium-release channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032591 [dendritic spine membrane]
GO:0034605 [cellular response to heat]
GO:0035091 [phosphatidylinositol binding]
GO:0042995 [cell projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0050955 [thermoception]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051219 [phosphoprotein binding]
GO:0051289 [protein homotetramerization]
GO:0055085 [transmembrane transport]
GO:0060079 [excitatory postsynaptic potential]
GO:0070588 [calcium ion transmembrane transport]
GO:0071312 [cellular response to alkaloid]
GO:0071318 [cellular response to ATP]
GO:0071468 [cellular response to acidic pH]
GO:0098703 [calcium ion import across plasma membrane]
GO:1901594 [response to capsazepine]
Show all
839 aa
95 kDa
No 6
TRPV1-207
ENSP00000459962
ENST00000572705
Q8NER1 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000166 [nucleotide binding]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005216 [ion channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005231 [excitatory extracellular ligand-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007635 [chemosensory behavior]
GO:0015278 [calcium-release channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032591 [dendritic spine membrane]
GO:0034605 [cellular response to heat]
GO:0035091 [phosphatidylinositol binding]
GO:0042995 [cell projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0050955 [thermoception]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051219 [phosphoprotein binding]
GO:0051289 [protein homotetramerization]
GO:0055085 [transmembrane transport]
GO:0060079 [excitatory postsynaptic potential]
GO:0070588 [calcium ion transmembrane transport]
GO:0071312 [cellular response to alkaloid]
GO:0071318 [cellular response to ATP]
GO:0071468 [cellular response to acidic pH]
GO:0098703 [calcium ion import across plasma membrane]
GO:1901594 [response to capsazepine]
Show all
839 aa
95 kDa
No 6
TRPV1-209
ENSP00000459042
ENST00000576351
I3L1R6 [Direct mapping]
Osm-9-like TRP channel 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0000166 [nucleotide binding]
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032591 [dendritic spine membrane]
GO:0034220 [ion transmembrane transport]
GO:0045211 [postsynaptic membrane]
GO:0055085 [transmembrane transport]
Show all
829 aa
93.9 kDa
No 6

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