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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:59.4 nTPM
HPA:59.4 nTPM
GTEx:48.5 nTPM
FANTOM5:143.8 Scaled Tags Per Million
Pig:46.1 nTPM
Mouse:43.0 nTPM
Allen mouse:0.3 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 59.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 48.1
1830 Male, age 51, unknown 60.6
2411 Female, age 72, unknown 57.3
2019 Male, age 18, unknown 57.2
1833 Male, age 53, unknown 53.8
1870 Female, age 42, unknown 52.9
2586 Male, age 75, left hemisphere 45.9
2828 Female, age 72, unknown 42.7
2666 Male, age 74, left hemisphere 41.8
2219 Male, age 76, both hemispheres 35.1
1827 Male, age 72, unknown 34.0
Dorsal raphe nucleus
nTPM: 35.6
2750 Male, age 76, both hemispheres 57.6
1828 Male, age 53, unknown 36.2
2016 Female, age 72, unknown 33.6
2047 Male, age 72, unknown 29.1
2298 Female, age 72, unknown 21.6
Inferior colliculus
nTPM: 32.4
1890 Male, age 53, unknown 40.1
1848 Female, age 42, unknown 32.9
2849 Male, age 72, unknown 30.1
2097 Female, age 72, unknown 26.6
Median raphe nucleus
nTPM: 33.2
2220 Male, age 76, midline 33.2
Pedunculopontine tegmental nucleus
nTPM: 40.9
2338 Male, age 61, both hemispheres 43.6
2334 Male, age 80, both hemispheres 42.8
1921 Female, age 85, both hemispheres 36.5
Periaquaductal grey, anterior
nTPM: 30.3
2502 Female, age 75, unknown 33.5
1947 Male, age 18, unknown 30.1
1795 Male, age 51, unknown 27.2
Periaquaductal grey, dorsal
nTPM: 25.3
2464 Female, age 72, unknown 34.0
1831 Male, age 72, unknown 28.3
2850 Male, age 76, both hemispheres 21.3
1840 Male, age 53, unknown 17.4
Periaquaductal grey, lateral
nTPM: 29.1
2053 Male, age 18, unknown 33.2
2272 Male, age 74, both hemispheres 30.9
2140 Male, age 76, both hemispheres 23.1
Pretectal area
nTPM: 31.9
2407 Male, age 75, both hemispheres 44.2
2316 Male, age 76, right hemisphere 41.9
1815 Male, age 53, unknown 39.1
2825 Male, age 18, unknown 34.1
2007 Male, age 72, unknown 32.2
1817 Female, age 42, unknown 29.4
2273 Male, age 74, both hemispheres 29.4
2667 Female, age 75, unknown 29.3
2224 Female, age 72, unknown 26.3
1944 Female, age 72, unknown 23.5
1816 Male, age 51, unknown 21.3
Red nucleus
nTPM: 59.4
1865 Male, age 51, unknown 69.6
2823 Male, age 76, right hemisphere 66.9
1904 Male, age 53, unknown 66.1
2769 Male, age 72, unknown 63.1
2227 Male, age 72, unknown 61.9
2785 Male, age 18, unknown 61.9
2588 Male, age 74, left hemisphere 61.4
1821 Female, age 72, unknown 57.8
2503 Female, age 72, unknown 56.4
2584 Male, age 75, left hemisphere 54.4
1954 Female, age 42, unknown 52.7
2725 Female, age 75, unknown 40.0
Substantia nigra
nTPM: 38.6
2583 Male, age 75, right hemisphere 49.4
2409 Female, age 72, unknown 45.6
2590 Female, age 75, unknown 44.1
1851 Male, age 51, unknown 40.5
2699 Male, age 18, unknown 37.3
1889 Female, age 72, unknown 36.8
2241 Male, age 72, unknown 36.6
1941 Male, age 53, unknown 34.5
2665 Male, age 74, both hemispheres 31.2
1916 Female, age 42, unknown 29.6
Superior colliculus
nTPM: 39.3
1913 Female, age 42, unknown 57.1
1995 Male, age 72, unknown 50.8
2668 Female, age 75, unknown 46.6
1895 Male, age 76, right hemisphere 43.8
2587 Male, age 74, left hemisphere 42.6
1839 Male, age 51, unknown 37.8
2664 Male, age 75, both hemispheres 34.7
1796 Male, age 53, unknown 29.8
2087 Female, age 72, unknown 25.8
2261 Male, age 18, unknown 24.0
Ventral tegmental area
nTPM: 43.3
2223 Female, age 72, unknown 64.3
2410 Female, age 72, unknown 47.6
1942 Male, age 51, unknown 41.6
2021 Male, age 53, unknown 38.2
2218 Male, age 76, both hemispheres 36.2
1915 Female, age 42, unknown 32.1

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 48.5
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 48.5
Samples: 139

Max nTPM: 154.6
Min nTPM: 15.4
Std nTPM: 22.5
Median nTPM: 44.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 154.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 137.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 130.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 97.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 94.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 93.9
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 90.6
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 87.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 86.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 84.9
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 74.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 74.5
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 74.2
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 72.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 71.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 67.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 67.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 67.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 66.4
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 65.4
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 65.2
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 64.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 64.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 64.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 63.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 62.6
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 62.6
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 62.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 62.4
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 62.4
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 61.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 60.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 60.2
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 60.0
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 59.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 59.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 59.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 59.6
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 59.4
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 59.2
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 58.7
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 58.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 58.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 58.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 57.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 57.4
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 55.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 55.4
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 54.5
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 53.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 53.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 53.1
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 52.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 52.3
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 51.5
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 51.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 50.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 50.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 49.3
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 48.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 48.2
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 47.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 47.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 46.9
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 46.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 46.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 45.5
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 45.5
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 45.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 44.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 44.3
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 44.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 44.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 44.1
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 44.0
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 42.9
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 42.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 42.8
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 41.9
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 41.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 40.7
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 39.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 38.7
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 38.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 38.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 38.0
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 37.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 37.4
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 37.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 37.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 37.1
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 35.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 34.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 34.6
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 34.3
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 34.2
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 33.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 33.8
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 33.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 33.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 33.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 33.2
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 33.1
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 32.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 32.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 32.5
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 32.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 31.3
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 31.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 30.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 30.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 30.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 29.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 29.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 28.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 28.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 28.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 27.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 27.6
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 27.3
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 27.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 27.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 26.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 25.7
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 25.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 24.5
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 24.2
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 23.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 22.7
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 22.5
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 22.5
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 22.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 22.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 21.9
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 21.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 20.8
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 20.4
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 17.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 15.4
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 143.8
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 143.8
FF:10158-103A5 76 years, female 143.8

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 46.1
Pig sample Sample description nTPM
Midbrain
nTPM: 46.1
Samples: 4

Max nTPM: 68.7
Min nTPM: 35.5
Sample A Female 68.7
Sample B Female 39.3
Sample C Male 40.8
Sample D Male 35.5
Periaqueductal gray
nTPM: 32.6
Samples: 3

Max nTPM: 33.4
Min nTPM: 31.7
Sample B Female 33.4
Sample C Male 31.7
Sample D Male 32.6
Substantia nigra
nTPM: 42.3
Samples: 4

Max nTPM: 48.8
Min nTPM: 31.9
Sample A Female 46.4
Sample B Female 31.9
Sample C Male 42.1
Sample D Male 48.8
Superior colliculi
nTPM: 37.5
Samples: 4

Max nTPM: 46.5
Min nTPM: 21.3
Sample A Female 40.4
Sample B Female 21.3
Sample C Male 41.8
Sample D Male 46.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 43.0
Mouse sample Sample description nTPM
Midbrain
nTPM: 43.0
Samples: 4

Max nTPM: 45.4
Min nTPM: 40.8
Sample A Male 40.8
Sample B Male 41.2
Sample C Female 45.4
Sample D Female 44.7

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.3
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.3
71493057 Antisense, RP_050913_02_A12, Mouse strain C57BL/6J (56 days, male) 0.3

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