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FLNA
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  • FLNA
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

FLNA
Synonyms ABP-280, FLN, FLN1, OPD1, OPD2
Gene descriptioni

Full gene name according to HGNC.

Filamin A
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Human disease related genes
Plasma proteins
Potential drug targets
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome X
Cytoband q28
Chromosome location (bp) 154348524 - 154374634
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

7
Ensembl ENSG00000196924 (version 103.38)
Entrez gene 2316
HGNC HGNC:3754
UniProt P21333 (UniProt - Evidence at protein level)
neXtProt NX_P21333
Antibodypedia FLNA antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 30      # Population variants: 1000

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
FLNA-201
FLNA-202
FLNA-203
FLNA-206
FLNA-207
FLNA-208
FLNA-219


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
FLNA-201
ENSP00000353467
ENST00000360319
P21333 [Direct mapping]
Filamin-A
Show all
Transporters
   Accessory Factors Involved in Transport
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
   Congenital malformations
   Congenital malformations of the nervous system
   Congenital malformations of the circulatory system
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
   Digestive system diseases
   Gastrointestinal diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G protein-coupled receptor binding]
GO:0002576 [platelet degranulation]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0015459 [potassium channel regulator activity]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016479 [negative regulation of transcription by RNA polymerase I]
GO:0019900 [kinase binding]
GO:0030018 [Z disc]
GO:0030030 [cell projection organization]
GO:0030168 [platelet activation]
GO:0030334 [regulation of cell migration]
GO:0030426 [growth cone]
GO:0031267 [small GTPase binding]
GO:0031523 [Myb complex]
GO:0031532 [actin cytoskeleton reorganization]
GO:0034329 [cell junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042803 [protein homodimerization activity]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043113 [receptor clustering]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043204 [perikaryon]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0044319 [wound healing, spreading of cells]
GO:0044325 [ion channel binding]
GO:0045184 [establishment of protein localization]
GO:0045296 [cadherin binding]
GO:0050821 [protein stabilization]
GO:0051015 [actin filament binding]
GO:0051020 [GTPase binding]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051607 [defense response to virus]
GO:0051764 [actin crosslink formation]
GO:0060271 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0072659 [protein localization to plasma membrane]
GO:0090042 [tubulin deacetylation]
GO:0090307 [mitotic spindle assembly]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1905000 [regulation of membrane repolarization during atrial cardiac muscle cell action potential]
GO:1905031 [regulation of membrane repolarization during cardiac muscle cell action potential]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
2639 aa
280 kDa
No 0
FLNA-202
ENSP00000358866
ENST00000369850
P21333 [Direct mapping]
Filamin-A
Show all
Transporters
   Accessory Factors Involved in Transport
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
   Congenital malformations
   Congenital malformations of the nervous system
   Congenital malformations of the circulatory system
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
   Digestive system diseases
   Gastrointestinal diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001664 [G protein-coupled receptor binding]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002576 [platelet degranulation]
GO:0003007 [heart morphogenesis]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0010977 [negative regulation of neuron projection development]
GO:0015459 [potassium channel regulator activity]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016479 [negative regulation of transcription by RNA polymerase I]
GO:0019900 [kinase binding]
GO:0021943 [formation of radial glial scaffolds]
GO:0021987 [cerebral cortex development]
GO:0030018 [Z disc]
GO:0030030 [cell projection organization]
GO:0030036 [actin cytoskeleton organization]
GO:0030168 [platelet activation]
GO:0030334 [regulation of cell migration]
GO:0030426 [growth cone]
GO:0030863 [cortical cytoskeleton]
GO:0031267 [small GTPase binding]
GO:0031523 [Myb complex]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031852 [mu-type opioid receptor binding]
GO:0032231 [regulation of actin filament bundle assembly]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0032432 [actin filament bundle]
GO:0034329 [cell junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042789 [mRNA transcription by RNA polymerase II]
GO:0042803 [protein homodimerization activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043113 [receptor clustering]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043198 [dendritic shaft]
GO:0043204 [perikaryon]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0044295 [axonal growth cone]
GO:0044319 [wound healing, spreading of cells]
GO:0044325 [ion channel binding]
GO:0044877 [protein-containing complex binding]
GO:0045022 [early endosome to late endosome transport]
GO:0045184 [establishment of protein localization]
GO:0045216 [cell-cell junction organization]
GO:0045296 [cadherin binding]
GO:0046332 [SMAD binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048680 [positive regulation of axon regeneration]
GO:0050808 [synapse organization]
GO:0050821 [protein stabilization]
GO:0051015 [actin filament binding]
GO:0051020 [GTPase binding]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051607 [defense response to virus]
GO:0051764 [actin crosslink formation]
GO:0060271 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0072659 [protein localization to plasma membrane]
GO:0090042 [tubulin deacetylation]
GO:0090307 [mitotic spindle assembly]
GO:0097368 [establishment of Sertoli cell barrier]
GO:0097440 [apical dendrite]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902396 [protein localization to bicellular tight junction]
GO:1905000 [regulation of membrane repolarization during atrial cardiac muscle cell action potential]
GO:1905031 [regulation of membrane repolarization during cardiac muscle cell action potential]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
GO:2001224 [positive regulation of neuron migration]
Show all
2647 aa
280.7 kDa
No 0
FLNA-203
ENSP00000358872
ENST00000369856
Q60FE5 [Direct mapping]
Filamin-A
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
   Congenital malformations
   Congenital malformations of the nervous system
   Congenital malformations of the circulatory system
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
   Digestive system diseases
   Gastrointestinal diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0015629 [actin cytoskeleton]
Show all
2620 aa
278.2 kDa
No 0
FLNA-206
ENSP00000416926
ENST00000422373
P21333 [Direct mapping]
Filamin-A
Show all
Transporters
   Accessory Factors Involved in Transport
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
   Congenital malformations
   Congenital malformations of the nervous system
   Congenital malformations of the circulatory system
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
   Digestive system diseases
   Gastrointestinal diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G protein-coupled receptor binding]
GO:0002576 [platelet degranulation]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0015459 [potassium channel regulator activity]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016479 [negative regulation of transcription by RNA polymerase I]
GO:0019900 [kinase binding]
GO:0030018 [Z disc]
GO:0030030 [cell projection organization]
GO:0030168 [platelet activation]
GO:0030334 [regulation of cell migration]
GO:0030426 [growth cone]
GO:0031267 [small GTPase binding]
GO:0031523 [Myb complex]
GO:0031532 [actin cytoskeleton reorganization]
GO:0034329 [cell junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042803 [protein homodimerization activity]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043113 [receptor clustering]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043204 [perikaryon]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0044319 [wound healing, spreading of cells]
GO:0044325 [ion channel binding]
GO:0045184 [establishment of protein localization]
GO:0045296 [cadherin binding]
GO:0050821 [protein stabilization]
GO:0051015 [actin filament binding]
GO:0051020 [GTPase binding]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051607 [defense response to virus]
GO:0051764 [actin crosslink formation]
GO:0060271 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0072659 [protein localization to plasma membrane]
GO:0090042 [tubulin deacetylation]
GO:0090307 [mitotic spindle assembly]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1905000 [regulation of membrane repolarization during atrial cardiac muscle cell action potential]
GO:1905031 [regulation of membrane repolarization during cardiac muscle cell action potential]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
1574 aa
167.9 kDa
No 0
FLNA-207
ENSP00000398215
ENST00000438732
H0Y5F3 [Direct mapping]
Filamin-A
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
   Congenital malformations
   Congenital malformations of the nervous system
   Congenital malformations of the circulatory system
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
   Digestive system diseases
   Gastrointestinal diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0015629 [actin cytoskeleton]
Show all
232 aa
25 kDa
No 0
FLNA-208
ENSP00000397824
ENST00000444578
H0Y5C6 [Direct mapping]
Filamin-A
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
   Congenital malformations
   Congenital malformations of the nervous system
   Congenital malformations of the circulatory system
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
   Digestive system diseases
   Gastrointestinal diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
281 aa
29.9 kDa
No 0
FLNA-219
ENSP00000501210
ENST00000673639
A0A669KBC6 [Direct mapping]
Filamin-A
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
   Congenital malformations
   Congenital malformations of the nervous system
   Congenital malformations of the circulatory system
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
   Digestive system diseases
   Gastrointestinal diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
96 aa
10.1 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.