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SRC
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  • TISSUE

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  • SRC
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

SRC
Synonyms ASV, c-src, SRC1
Gene descriptioni

Full gene name according to HGNC.

SRC proto-oncogene, non-receptor tyrosine kinase
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Plasma proteins
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 20
Cytoband q11.23
Chromosome location (bp) 37344685 - 37406050
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

4
Ensembl ENSG00000197122 (version 103.38)
Entrez gene 6714
HGNC HGNC:11283
UniProt P12931 (UniProt - Evidence at protein level)
neXtProt NX_P12931
Antibodypedia SRC antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Experimental


Description: Src kinase in complex with a quinazoline inhibitor (X-ray)

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
SRC-201
SRC-202
SRC-203
SRC-204


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
SRC-201
ENSP00000350941
ENST00000358208
P12931 [Direct mapping]
Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0033625 [positive regulation of integrin activation]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
536 aa
59.8 kDa
No 0
SRC-202
ENSP00000362659
ENST00000373558
P12931 [Direct mapping]
Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001545 [primary ovarian follicle growth]
GO:0002102 [podosome]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005080 [protein kinase C binding]
GO:0005102 [signaling receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell population proliferation]
GO:0009612 [response to mechanical stimulus]
GO:0009615 [response to virus]
GO:0010447 [response to acidic pH]
GO:0010628 [positive regulation of gene expression]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010954 [positive regulation of protein processing]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014069 [postsynaptic density]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030331 [estrogen receptor binding]
GO:0030900 [forebrain development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031648 [protein destabilization]
GO:0031667 [response to nutrient levels]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032148 [activation of protein kinase B activity]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032587 [ruffle membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0033625 [positive regulation of integrin activation]
GO:0034332 [adherens junction organization]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043393 [regulation of protein binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044325 [ion channel binding]
GO:0044877 [protein-containing complex binding]
GO:0045056 [transcytosis]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048477 [oogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050839 [cell adhesion molecule binding]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051222 [positive regulation of protein transport]
GO:0051385 [response to mineralocorticoid]
GO:0051602 [response to electrical stimulus]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060065 [uterus development]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0060491 [regulation of cell projection assembly]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070542 [response to fatty acid]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071253 [connexin binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0071456 [cellular response to hypoxia]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071803 [positive regulation of podosome assembly]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097110 [scaffold protein binding]
GO:0098609 [cell-cell adhesion]
GO:0098962 [regulation of postsynaptic neurotransmitter receptor activity]
GO:0098978 [glutamatergic synapse]
GO:0099091 [postsynaptic specialization, intracellular component]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:2000386 [positive regulation of ovarian follicle development]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2000588 [positive regulation of platelet-derived growth factor receptor-beta signaling pathway]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
542 aa
60.6 kDa
No 0
SRC-203
ENSP00000362668
ENST00000373567
P12931 [Direct mapping]
Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0033625 [positive regulation of integrin activation]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
536 aa
59.8 kDa
No 0
SRC-204
ENSP00000362680
ENST00000373578
P12931 [Direct mapping]
Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0033625 [positive regulation of integrin activation]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
536 aa
59.8 kDa
No 0

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