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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q23.3
Chromosome location (bp)
136557046 - 136792477
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
MAP3K5-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q99683 [Direct mapping] Mitogen-activated protein kinase kinase kinase 5
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0000287 [magnesium ion binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0002376 [immune system process] GO:0002931 [response to ischemia] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007254 [JNK cascade] GO:0007257 [activation of JUN kinase activity] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0009897 [external side of plasma membrane] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0010941 [regulation of cell death] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019904 [protein domain specific binding] GO:0032991 [protein-containing complex] GO:0034198 [cellular response to amino acid starvation] GO:0034976 [response to endoplasmic reticulum stress] GO:0038066 [p38MAPK cascade] GO:0042060 [wound healing] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043507 [positive regulation of JUN kinase activity] GO:0045087 [innate immune response] GO:0045663 [positive regulation of myoblast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046330 [positive regulation of JNK cascade] GO:0046872 [metal ion binding] GO:0051403 [stress-activated MAPK cascade] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070301 [cellular response to hydrogen peroxide] GO:0071356 [cellular response to tumor necrosis factor] GO:0072577 [endothelial cell apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097300 [programmed necrotic cell death] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901216 [positive regulation of neuron death] GO:1902170 [cellular response to reactive nitrogen species] GO:1902911 [protein kinase complex] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:1990604 [IRE1-TRAF2-ASK1 complex]
The Human Protein Atlas project is funded
