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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q23.1
Chromosome location (bp)
156815640 - 156881850
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
NTRK1-201
NTRK1-202
NTRK1-203
NTRK1-206
NTRK1-211
NTRK1-212
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Cancers of endocrine organs Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000166 [nucleotide binding] GO:0000186 [activation of MAPKK activity] GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0008285 [negative regulation of cell population proliferation] GO:0010008 [endosome membrane] GO:0010465 [nerve growth factor receptor activity] GO:0010623 [programmed cell death involved in cell development] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030154 [cell differentiation] GO:0030424 [axon] GO:0031175 [neuron projection development] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0032991 [protein-containing complex] GO:0033674 [positive regulation of kinase activity] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0038180 [nerve growth factor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043068 [positive regulation of programmed cell death] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0043410 [positive regulation of MAPK cascade] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048406 [nerve growth factor binding] GO:0048485 [sympathetic nervous system development] GO:0048666 [neuron development] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051896 [regulation of protein kinase B signaling] GO:0055038 [recycling endosome membrane] GO:0060385 [axonogenesis involved in innervation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:1990090 [cellular response to nerve growth factor stimulus]
P04629 [Direct mapping] High affinity nerve growth factor receptor
Show all
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Cancers of endocrine organs Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000166 [nucleotide binding] GO:0000186 [activation of MAPKK activity] GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0008285 [negative regulation of cell population proliferation] GO:0010008 [endosome membrane] GO:0010465 [nerve growth factor receptor activity] GO:0010623 [programmed cell death involved in cell development] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030154 [cell differentiation] GO:0030424 [axon] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0032991 [protein-containing complex] GO:0033674 [positive regulation of kinase activity] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038180 [nerve growth factor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043068 [positive regulation of programmed cell death] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0043410 [positive regulation of MAPK cascade] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048406 [nerve growth factor binding] GO:0048485 [sympathetic nervous system development] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051896 [regulation of protein kinase B signaling] GO:0055038 [recycling endosome membrane] GO:0060385 [axonogenesis involved in innervation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:1990090 [cellular response to nerve growth factor stimulus]
P04629 [Direct mapping] High affinity nerve growth factor receptor
Show all
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of eye, brain, and central nervous system Cancers of endocrine organs Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000166 [nucleotide binding] GO:0000186 [activation of MAPKK activity] GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005004 [GPI-linked ephrin receptor activity] GO:0005030 [neurotrophin receptor activity] GO:0005166 [neurotrophin p75 receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007568 [aging] GO:0007611 [learning or memory] GO:0007623 [circadian rhythm] GO:0008285 [negative regulation of cell population proliferation] GO:0009314 [response to radiation] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0010465 [nerve growth factor receptor activity] GO:0010623 [programmed cell death involved in cell development] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019233 [sensory perception of pain] GO:0019900 [kinase binding] GO:0021553 [olfactory nerve development] GO:0030154 [cell differentiation] GO:0030183 [B cell differentiation] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031410 [cytoplasmic vesicle] GO:0031667 [response to nutrient levels] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0032991 [protein-containing complex] GO:0033674 [positive regulation of kinase activity] GO:0035094 [response to nicotine] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038180 [nerve growth factor signaling pathway] GO:0042490 [mechanoreceptor differentiation] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043068 [positive regulation of programmed cell death] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0043410 [positive regulation of MAPK cascade] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048406 [nerve growth factor binding] GO:0048485 [sympathetic nervous system development] GO:0048678 [response to axon injury] GO:0050965 [detection of temperature stimulus involved in sensory perception of pain] GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051599 [response to hydrostatic pressure] GO:0051602 [response to electrical stimulus] GO:0051896 [regulation of protein kinase B signaling] GO:0051965 [positive regulation of synapse assembly] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0055037 [recycling endosome] GO:0055038 [recycling endosome membrane] GO:0060009 [Sertoli cell development] GO:0060384 [innervation] GO:0060385 [axonogenesis involved in innervation] GO:0061368 [behavioral response to formalin induced pain] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071316 [cellular response to nicotine] GO:0071363 [cellular response to growth factor stimulus] GO:1901215 [negative regulation of neuron death] GO:1990090 [cellular response to nerve growth factor stimulus]
THUMBUP predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Cancers of endocrine organs Nervous system diseases Other nervous and sensory system diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
