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PANCREATIC CANCER - Interactive survival scatter ploti
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average FPKM
2075.2
Number of samples
176
Samples
Sample
Description
FPKM
TCGA-FB-AAPY-01A
71 years, male, white, stage:iib, dead, 1059 days
7364.1
TCGA-FB-AAQ3-01A
65 years, female, white, stage:iib, dead, 31 days
6016.4
TCGA-HV-A5A5-01A
61 years, female, asian, stage:iib, alive, 289 days
5328.0
TCGA-HZ-8315-01A
54 years, female, white, stage:iia, dead, 299 days
5262.7
TCGA-FB-AAQ0-01A
68 years, male, white, stage:iia, dead, 473 days
4699.4
TCGA-HV-AA8V-01A
50 years, male, asian, stage:iib, alive, 920 days
4673.8
TCGA-H8-A6C1-01A
53 years, male, white, stage:iia, alive, 671 days
4649.3
TCGA-M8-A5N4-01A
48 years, female, stage:iia, alive, 584 days
4473.5
TCGA-3A-A9IL-01A
39 years, female, white, stage:i, alive, 2741 days
4308.2
TCGA-IB-7649-01A
73 years, female, stage:iib, dead, 467 days
4225.3
TCGA-Q3-AA2A-01A
64 years, female, white, stage:ib, alive, 95 days
4165.0
TCGA-2J-AABK-01A
71 years, male, white, stage:iib, alive, 484 days
4113.8
TCGA-3A-A9IN-01A
62 years, female, white, stage:ib, alive, 2084 days
4005.2
TCGA-LB-A7SX-01A
74 years, female, black or african american, stage:iib, dead, 393 days
3846.0
TCGA-HZ-8638-01A
84 years, female, white, stage:ia, dead, 151 days
3813.8
TCGA-US-A779-01A
54 years, female, white, stage:iib, dead, 511 days
3703.0
TCGA-3A-A9IO-01A
56 years, male, white, alive, 1942 days
3677.7
TCGA-HV-A5A3-01A
50 years, male, asian, stage:iia, dead, 128 days
3665.6
TCGA-3A-A9I9-01A
67 years, male, white, stage:iia, dead, 634 days
3663.7
TCGA-2J-AABT-01A
72 years, female, white, stage:iib, alive, 319 days
3661.6
TCGA-HZ-A4BK-01A
72 years, male, white, stage:iib, alive, 657 days
3656.9
TCGA-3A-A9I7-01A
45 years, male, black or african american, stage:iib, alive, 1323 days
3637.5
TCGA-Q3-A5QY-01A
58 years, male, white, stage:iib, alive, 416 days
3600.2
TCGA-2L-AAQE-01A
56 years, male, white, stage:iib, dead, 684 days
3543.5
TCGA-2J-AABH-01A
61 years, male, white, stage:iia, alive, 1287 days
3478.8
TCGA-HZ-A49G-01A
58 years, female, white, stage:iib, alive, 660 days
3477.4
TCGA-S4-A8RP-01A
77 years, female, white, stage:iib, dead, 702 days
3422.8
TCGA-IB-AAUO-01A
64 years, female, white, stage:iib, dead, 239 days
3321.1
TCGA-2J-AABO-01A
43 years, male, white, stage:iib, alive, 440 days
3229.7
TCGA-HZ-A77P-01A
77 years, male, white, stage:iib, alive, 330 days
3132.3
TCGA-XD-AAUI-01A
50 years, female, white, stage:iib, dead, 366 days
3074.9
TCGA-3A-A9IR-01A
64 years, female, white, stage:ib, alive, 1542 days
3055.6
TCGA-FB-A545-01A
72 years, female, white, stage:iib, dead, 732 days
3041.3
TCGA-HZ-8637-01A
76 years, female, white, stage:iib, dead, 517 days
2987.3
TCGA-HZ-A49H-01A
68 years, female, white, stage:iib, alive, 491 days
2977.2
TCGA-3E-AAAY-01A
67 years, male, white, stage:iib, alive, 2285 days
2977.2
TCGA-2J-AABA-01A
55 years, male, white, stage:iib, dead, 607 days
2940.2
TCGA-IB-A5SO-01A
71 years, male, white, stage:iib, dead, 365 days
2911.7
TCGA-3A-A9IX-01A
40 years, male, white, stage:ia, alive, 1037 days
2840.6
TCGA-FB-A78T-01A
71 years, female, white, stage:iib, dead, 375 days
2812.1
TCGA-2J-AABE-01A
73 years, male, white, stage:iia, alive, 676 days
2804.0
TCGA-XD-AAUH-01A
57 years, female, white, stage:iib, alive, 395 days
2790.5
TCGA-2L-AAQJ-01A
49 years, female, white, stage:iii, dead, 394 days
2743.1
TCGA-2L-AAQL-01A
82 years, male, white, stage:iib, dead, 292 days
2721.4
TCGA-HV-A5A4-01A
72 years, female, asian, stage:iia, alive, 232 days
2704.5
TCGA-XN-A8T5-01A
53 years, female, white, stage:ib, alive, 720 days
2613.2
TCGA-H6-A45N-01A
88 years, female, white, stage:iib, dead, 421 days
2598.1
TCGA-FB-A4P5-01A
69 years, female, white, stage:iib, dead, 179 days
2554.5
TCGA-2J-AABR-01A
60 years, female, white, stage:iia, alive, 438 days
2511.6
TCGA-2L-AAQI-01A
66 years, male, white, stage:iib, dead, 103 days
2492.1
TCGA-FB-AAQ1-01A
49 years, male, white, stage:iib, dead, 123 days
2487.1
TCGA-IB-AAUW-01A
63 years, female, white, stage:iib, dead, 230 days
2481.8
TCGA-2L-AAQM-01A
52 years, male, white, stage:iib, alive, 1383 days
2479.1
TCGA-F2-A44G-01A
79 years, female, white, stage:iib, dead, 233 days
2477.3
TCGA-3A-A9J0-01A
75 years, male, white, stage:iib, alive, 743 days
2460.8
TCGA-US-A77G-01A
64 years, male, white, stage:iib, dead, 12 days
2438.4
TCGA-IB-7887-01A
62 years, female, white, stage:iib, dead, 110 days
2366.3
TCGA-IB-7645-01A
44 years, female, stage:iib, dead, 1502 days
2358.2
TCGA-IB-7885-01A
78 years, female, white, stage:iib, alive, 1257 days
2340.6
TCGA-3A-A9IH-01A
66 years, female, white, stage:ia, alive, 1021 days
2333.2
TCGA-IB-AAUQ-01A
50 years, male, white, stage:iib, dead, 183 days
2327.2
TCGA-XD-AAUL-01A
56 years, male, white, stage:iia, alive, 498 days
2309.8
TCGA-HZ-8001-01A
69 years, male, white, stage:iii, alive, 706 days
2302.7
TCGA-XD-AAUG-01A
66 years, female, white, stage:iv, alive, 420 days
2296.5
TCGA-3A-A9IU-01A
65 years, male, white, stage:iib, dead, 458 days
2255.7
TCGA-HZ-7923-01A
65 years, male, white, stage:iia, alive, 314 days
2222.1
TCGA-HV-A7OL-01A
70 years, male, asian, stage:iia, alive, 252 days
2192.0
TCGA-2J-AABU-01A
56 years, male, white, stage:iib, dead, 277 days
2168.2
TCGA-XN-A8T3-01A
67 years, male, white, stage:ib, alive, 951 days
2167.4
TCGA-HZ-A49I-01A
77 years, male, white, stage:iib, dead, 308 days
2166.5
TCGA-3A-A9IV-01A
59 years, female, white, stage:ib, alive, 1103 days
2164.4
TCGA-FB-AAPZ-01A
54 years, male, white, stage:iib, alive, 716 days
2156.2
TCGA-YH-A8SY-01A
73 years, female, white, alive, 388 days
2136.6
TCGA-FB-AAQ6-01A
85 years, male, white, stage:ia, dead, 244 days
2133.9
TCGA-HZ-7289-01A
77 years, male, white, stage:iib, dead, 661 days
2110.2
TCGA-H6-8124-01A
56 years, female, white, stage:iib, alive, 392 days
2109.3
TCGA-US-A77J-01A
81 years, female, white, stage:iib, dead, 568 days
2099.1
TCGA-US-A77E-01A
73 years, male, white, stage:iib, dead, 430 days
2085.6
TCGA-HV-A5A6-01A
65 years, female, asian, stage:iib, dead, 2036 days
2065.0
TCGA-FB-AAPS-01A
62 years, female, white, stage:iib, alive, 228 days
2054.2
TCGA-IB-A6UF-01A
63 years, male, white, stage:iib, alive, 666 days
2023.5
TCGA-HZ-8317-01A
69 years, female, white, stage:iib, dead, 378 days
2007.5
TCGA-IB-7890-01A
73 years, male, stage:ib, dead, 598 days
1931.4
TCGA-IB-A5SP-01A
77 years, male, white, stage:iia, alive, 482 days
1927.1
TCGA-IB-7652-01A
49 years, female, asian, stage:iib, alive, 1116 days
1892.9
TCGA-HZ-8519-01A
73 years, male, white, stage:ia, alive, 454 days
1854.6
TCGA-3A-A9IB-01A
69 years, female, white, stage:iib, dead, 224 days
1830.4
TCGA-IB-8126-01A
80 years, female, white, stage:iii, alive, 462 days
1811.9
TCGA-IB-7889-01A
86 years, female, white, stage:iib, dead, 481 days
1804.7
TCGA-FB-A4P6-01A
54 years, male, white, stage:iib, alive, 767 days
1781.4
TCGA-IB-AAUV-01A
49 years, male, white, stage:iib, alive, 404 days
1775.7
TCGA-3A-A9IS-01A
67 years, male, white, stage:ib, alive, 998 days
1751.9
TCGA-HZ-A77Q-01A
55 years, female, white, stage:iib, alive, 33 days
1745.0
TCGA-IB-8127-01A
59 years, male, white, stage:iib, alive, 522 days
1724.3
TCGA-HZ-7920-01A
71 years, male, white, stage:ib, dead, 236 days
1716.7
TCGA-US-A776-01A
61 years, male, white, stage:iia, alive, 1216 days
1715.2
TCGA-HZ-8002-01A
61 years, male, white, stage:iib, dead, 366 days
1697.1
TCGA-HZ-A8P1-01A
81 years, male, white, stage:ib, alive, 7 days
1687.1
TCGA-RL-AAAS-01A
60 years, female, white, stage:ib, alive, 9 days
1663.8
TCGA-HZ-7924-01A
60 years, female, white, stage:iia, alive, 840 days
1656.5
TCGA-2J-AABI-01A
55 years, female, white, stage:iia, alive, 969 days
1650.4
TCGA-HZ-A4BH-01A
75 years, male, white, stage:iib, alive, 194 days
1644.0
TCGA-3A-A9IC-01A
61 years, female, white, stage:iib, dead, 738 days
1623.9
TCGA-HZ-7926-01A
57 years, male, black or african american, stage:iib, dead, 518 days
1603.4
TCGA-RB-AA9M-01A
43 years, male, white, stage:iib, alive, 286 days
1582.6
TCGA-HZ-A77O-01A
77 years, female, white, stage:iib, dead, 160 days
1575.5
TCGA-HZ-8636-01A
58 years, female, white, stage:iv, dead, 545 days
1568.0
TCGA-IB-AAUP-01A
68 years, male, white, stage:iib, alive, 431 days
1553.6
TCGA-S4-A8RO-01A
75 years, female, white, stage:iib, alive, 525 days
1552.2
TCGA-IB-AAUM-01A
76 years, male, white, stage:iib, alive, 8 days
1540.2
TCGA-S4-A8RM-01A
67 years, male, white, stage:iib, alive, 737 days
1518.8
TCGA-IB-AAUT-01A
65 years, male, white, stage:iib, alive, 287 days
1498.2
TCGA-IB-A5SQ-01A
56 years, female, white, stage:ib, dead, 219 days
1487.0
TCGA-IB-AAUR-01A
67 years, male, white, stage:iib, alive, 338 days
1485.4
TCGA-IB-AAUN-01A
74 years, female, white, stage:ib, dead, 144 days
1431.3
TCGA-IB-7897-01A
54 years, female, white, stage:iib, dead, 486 days
1421.1
TCGA-3A-A9I5-01A
58 years, male, white, alive, 1794 days
1415.7
TCGA-US-A774-01A
76 years, female, white, stage:iib, dead, 695 days
1406.7
TCGA-F2-7276-01A
64 years, male, white, stage:iib, dead, 216 days
1390.7
TCGA-2J-AABF-01A
73 years, male, white, stage:iib, dead, 691 days
1375.3
TCGA-HZ-7919-01A
52 years, female, white, stage:iib, dead, 593 days
1351.0
TCGA-IB-7644-01A
65 years, female, white, stage:iv, dead, 394 days
1350.5
TCGA-2J-AAB1-01A
65 years, male, white, stage:iib, dead, 66 days
1338.1
TCGA-IB-A5ST-01A
64 years, female, white, stage:iib, alive, 635 days
1335.0
TCGA-RB-A7B8-01A
81 years, female, white, stage:iib, dead, 466 days
1267.9
TCGA-YY-A8LH-01A
61 years, female, white, stage:iib, alive, 2016 days
1264.4
TCGA-L1-A7W4-01A
48 years, female, white, stage:iib, dead, 278 days
1250.4
TCGA-HZ-A9TJ-01A
70 years, male, white, stage:iv, alive, 603 days
1249.5
TCGA-F2-6880-01A
70 years, male, white, stage:iib, alive, 289 days
1225.5
TCGA-FB-A7DR-01A
48 years, male, asian, stage:iia, dead, 353 days
1187.2
TCGA-IB-7646-01A
60 years, male, white, stage:iib, dead, 145 days
1173.1
TCGA-IB-AAUS-01A
84 years, female, white, stage:iib, alive, 225 days
1159.4
TCGA-F2-A7TX-01A
77 years, male, white, stage:iib, dead, 95 days
1147.4
TCGA-IB-7888-01A
66 years, female, black or african american, stage:iia, dead, 1332 days
1129.3
TCGA-2L-AAQA-01A
76 years, male, white, stage:iib, dead, 143 days
1127.2
TCGA-IB-A6UG-01A
65 years, male, white, stage:iib, dead, 41 days
1123.3
TCGA-IB-7651-01A
64 years, female, white, stage:iib, dead, 603 days
1097.8
TCGA-F2-A44H-01A
65 years, male, white, stage:iia, alive, 586 days
1090.6
TCGA-IB-AAUU-01A
35 years, male, white, stage:iib, alive, 245 days
1081.4
TCGA-FB-AAPU-01A
41 years, female, asian, stage:iia, dead, 381 days
1073.1
TCGA-FB-A5VM-01A
74 years, male, white, stage:ib, dead, 498 days
1037.4
TCGA-IB-A5SS-01A
64 years, female, white, stage:iib, dead, 460 days
1031.8
TCGA-FB-AAPP-01A
71 years, male, white, stage:iib, dead, 485 days
1021.2
TCGA-2J-AABV-01A
74 years, male, white, stage:iib, dead, 652 days
1007.0
TCGA-2J-AAB4-01A
48 years, male, white, stage:iib, alive, 729 days
994.5
TCGA-3A-A9IJ-01A
65 years, male, white, stage:ib, alive, 1854 days
993.8
TCGA-LB-A9Q5-01A
63 years, female, white, stage:iib, dead, 313 days
970.7
TCGA-HV-AA8X-01A
75 years, female, asian, stage:iib, dead, 532 days
966.5
TCGA-PZ-A5RE-01A
44 years, female, white, stage:iib, dead, 470 days
943.4
TCGA-IB-7891-01A
49 years, female, white, stage:iib, dead, 913 days
919.7
TCGA-FB-AAPQ-01A
65 years, male, white, stage:iib, dead, 1130 days
917.7
TCGA-Z5-AAPL-01A
74 years, female, white, stage:iia, alive, 467 days
885.0
TCGA-HZ-8003-01A
65 years, female, white, stage:iib, dead, 596 days
874.9
TCGA-HZ-7922-01A
61 years, female, white, stage:iib, alive, 4 days
866.7
TCGA-2J-AAB6-01A
75 years, male, white, stage:iia, dead, 293 days
851.9
TCGA-FB-AAQ2-01A
81 years, female, white, stage:iib, dead, 153 days
841.0
TCGA-YB-A89D-01A
59 years, male, white, stage:iib, alive, 350 days
830.9
TCGA-IB-7654-01A
80 years, male, white, stage:iib, dead, 476 days
827.8
TCGA-HZ-8005-01A
81 years, male, white, stage:iib, dead, 120 days
820.6
TCGA-HZ-7925-01A
66 years, male, white, stage:iib, dead, 614 days
814.8
TCGA-3E-AAAZ-01A
71 years, male, white, stage:iia, dead, 2182 days
791.3
TCGA-HZ-7918-01A
72 years, male, white, stage:iib, alive, 969 days
763.2
TCGA-OE-A75W-01A
75 years, male, white, stage:iia, dead, 267 days
715.5
TCGA-IB-A7M4-01A
81 years, male, white, stage:iib, alive, 483 days
713.8
TCGA-LB-A8F3-01A
64 years, female, black or african american, stage:iia, alive, 379 days
694.1
TCGA-F2-7273-01A
54 years, male, black or african american, stage:iib, dead, 592 days
640.8
TCGA-IB-7893-01A
64 years, male, white, stage:iia, dead, 117 days
583.9
TCGA-IB-A7LX-01A
57 years, male, white, stage:iib, dead, 250 days
535.0
TCGA-3A-A9IZ-01A
47 years, male, white, stage:iib, dead, 308 days
519.8
TCGA-2J-AAB9-01A
71 years, female, white, stage:iib, dead, 627 days
506.4
TCGA-HV-A7OP-01A
72 years, male, asian, stage:iib, alive, 978 days
478.1
TCGA-F2-A8YN-01A
76 years, male, white, stage:iia, alive, 517 days
464.2
TCGA-2J-AAB8-01A
71 years, male, white, stage:iib, alive, 80 days
385.6
TCGA-F2-6879-01A
57 years, male, white, stage:iib, dead, 334 days
372.1
TCGA-IB-7886-01A
80 years, male, white, stage:iib, dead, 123 days
335.7
TCGA-2J-AABP-01A
58 years, female, white, stage:iib, alive, 463 days
270.9
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PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.