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MTOR
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  • MTOR
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

MTOR
Synonyms FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Gene descriptioni

Full gene name according to HGNC.

Mechanistic target of rapamycin kinase
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 1
Cytoband p36.22
Chromosome location (bp) 11106535 - 11262551
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
Ensembl ENSG00000198793 (version 103.38)
Entrez gene 2475
HGNC HGNC:3942
UniProt P42345 (UniProt - Evidence at protein level)
neXtProt NX_P42345
Antibodypedia MTOR antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 19      # Population variants: 862

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
MTOR-201
MTOR-202
MTOR-203


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
MTOR-201
ENSP00000354558
ENST00000361445
P42345 [Direct mapping]
Serine/threonine-protein kinase mTOR
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0001002 [RNA polymerase III type 1 promoter sequence-specific DNA binding]
GO:0001003 [RNA polymerase III type 2 promoter sequence-specific DNA binding]
GO:0001006 [RNA polymerase III type 3 promoter sequence-specific DNA binding]
GO:0001156 [TFIIIC-class transcription factor complex binding]
GO:0001558 [regulation of cell growth]
GO:0001932 [regulation of protein phosphorylation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002296 [T-helper 1 cell lineage commitment]
GO:0003007 [heart morphogenesis]
GO:0003179 [heart valve morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006109 [regulation of carbohydrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process]
GO:0006468 [protein phosphorylation]
GO:0007040 [lysosome organization]
GO:0007050 [cell cycle arrest]
GO:0007281 [germ cell development]
GO:0007420 [brain development]
GO:0007569 [cell aging]
GO:0007584 [response to nutrient]
GO:0007616 [long-term memory]
GO:0008361 [regulation of cell size]
GO:0008542 [visual learning]
GO:0009267 [cellular response to starvation]
GO:0009791 [post-embryonic development]
GO:0010506 [regulation of autophagy]
GO:0010507 [negative regulation of autophagy]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010831 [positive regulation of myotube differentiation]
GO:0010942 [positive regulation of cell death]
GO:0010976 [positive regulation of neuron projection development]
GO:0012505 [endomembrane system]
GO:0014042 [positive regulation of neuron maturation]
GO:0014736 [negative regulation of muscle atrophy]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0016241 [regulation of macroautophagy]
GO:0016242 [negative regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0021510 [spinal cord development]
GO:0030030 [cell projection organization]
GO:0030163 [protein catabolic process]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031090 [organelle membrane]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031529 [ruffle organization]
GO:0031641 [regulation of myelination]
GO:0031667 [response to nutrient levels]
GO:0031669 [cellular response to nutrient levels]
GO:0031929 [TOR signaling]
GO:0031931 [TORC1 complex]
GO:0031932 [TORC2 complex]
GO:0031998 [regulation of fatty acid beta-oxidation]
GO:0032095 [regulation of response to food]
GO:0032148 [activation of protein kinase B activity]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0032868 [response to insulin]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0032991 [protein-containing complex]
GO:0034198 [cellular response to amino acid starvation]
GO:0035176 [social behavior]
GO:0035264 [multicellular organism growth]
GO:0038202 [TORC1 signaling]
GO:0042060 [wound healing]
GO:0042220 [response to cocaine]
GO:0042752 [regulation of circadian rhythm]
GO:0042802 [identical protein binding]
GO:0043022 [ribosome binding]
GO:0043025 [neuronal cell body]
GO:0043087 [regulation of GTPase activity]
GO:0043200 [response to amino acid]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043276 [anoikis]
GO:0043278 [response to morphine]
GO:0043610 [regulation of carbohydrate utilization]
GO:0044877 [protein-containing complex binding]
GO:0045182 [translation regulator activity]
GO:0045335 [phagocytic vesicle]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045727 [positive regulation of translation]
GO:0045792 [negative regulation of cell size]
GO:0045859 [regulation of protein kinase activity]
GO:0045945 [positive regulation of transcription by RNA polymerase III]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048255 [mRNA stabilization]
GO:0048511 [rhythmic process]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0048738 [cardiac muscle tissue development]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050769 [positive regulation of neurogenesis]
GO:0050882 [voluntary musculoskeletal movement]
GO:0051219 [phosphoprotein binding]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051549 [positive regulation of keratinocyte migration]
GO:0051647 [nucleus localization]
GO:0051896 [regulation of protein kinase B signaling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055006 [cardiac cell development]
GO:0055013 [cardiac muscle cell development]
GO:0060048 [cardiac muscle contraction]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060252 [positive regulation of glial cell proliferation]
GO:0060999 [positive regulation of dendritic spine development]
GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development]
GO:0070885 [negative regulation of calcineurin-NFAT signaling cascade]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071233 [cellular response to leucine]
GO:0071456 [cellular response to hypoxia]
GO:0090335 [regulation of brown fat cell differentiation]
GO:0090559 [regulation of membrane permeability]
GO:0098978 [glutamatergic synapse]
GO:0099524 [postsynaptic cytosol]
GO:0099547 [regulation of translation at synapse, modulating synaptic transmission]
GO:0106310 []
GO:0106311 []
GO:1900034 [regulation of cellular response to heat]
GO:1901216 [positive regulation of neuron death]
GO:1901838 [positive regulation of transcription of nucleolar large rRNA by RNA polymerase I]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
GO:1904000 [positive regulation of eating behavior]
GO:1904056 [positive regulation of cholangiocyte proliferation]
GO:1904058 [positive regulation of sensory perception of pain]
GO:1904059 [regulation of locomotor rhythm]
GO:1904193 [negative regulation of cholangiocyte apoptotic process]
GO:1904197 [positive regulation of granulosa cell proliferation]
GO:1904206 [positive regulation of skeletal muscle hypertrophy]
GO:1904213 [negative regulation of iodide transmembrane transport]
GO:1904690 [positive regulation of cytoplasmic translational initiation]
GO:1990253 [cellular response to leucine starvation]
Show all
2549 aa
288.9 kDa
No 0
MTOR-202
ENSP00000366034
ENST00000376838
B1AKP8 [Direct mapping]
Non-specific serine/threonine protein kinase
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0044877 [protein-containing complex binding]
GO:0106310 []
GO:0106311 []
Show all
754 aa
85.9 kDa
No 0
MTOR-203
ENSP00000398745
ENST00000455339
B1AKQ2 [Direct mapping]
Serine/threonine-protein kinase mTOR
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
Show all
161 aa
18.2 kDa
No 0

Contact

  • NEWS ARTICLES
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS

The Human Protein Atlas

  • DOWNLOADABLE DATA
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.