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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:152802.2 nTPM
HPA:152802.2 nTPM
GTEx:105565.1 nTPM
Pig:73449.3 nTPM
Mouse:30959.9 nTPM
Allen mouse:24.0 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 152802.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 145918.7
2586 Male, age 75, left hemisphere 179668.4
2828 Female, age 72, unknown 159918.9
2666 Male, age 74, left hemisphere 152281.5
2219 Male, age 76, both hemispheres 152155.7
1833 Male, age 53, unknown 141581.2
2019 Male, age 18, unknown 139576.9
1870 Female, age 42, unknown 138177.5
1827 Male, age 72, unknown 136899.4
1830 Male, age 51, unknown 136108.7
2411 Female, age 72, unknown 122818.9
Dorsal raphe nucleus
nTPM: 133299.6
1828 Male, age 53, unknown 145991.9
2047 Male, age 72, unknown 135345.6
2750 Male, age 76, both hemispheres 133900.2
2016 Female, age 72, unknown 131391.8
2298 Female, age 72, unknown 119868.6
Inferior colliculus
nTPM: 136766.0
2849 Male, age 72, unknown 142647.3
1890 Male, age 53, unknown 141860.6
1848 Female, age 42, unknown 137463.0
2097 Female, age 72, unknown 125093.2
Median raphe nucleus
nTPM: 147957.7
2220 Male, age 76, midline 147957.7
Pedunculopontine tegmental nucleus
nTPM: 140051.2
2334 Male, age 80, both hemispheres 153022.4
2338 Male, age 61, both hemispheres 137132.7
1921 Female, age 85, both hemispheres 129998.6
Periaquaductal grey, anterior
nTPM: 133347.4
2502 Female, age 75, unknown 139636.7
1795 Male, age 51, unknown 131617.0
1947 Male, age 18, unknown 128788.5
Periaquaductal grey, dorsal
nTPM: 134249.3
2850 Male, age 76, both hemispheres 139835.2
1831 Male, age 72, unknown 134706.6
2464 Female, age 72, unknown 131753.0
1840 Male, age 53, unknown 130702.5
Periaquaductal grey, lateral
nTPM: 124354.0
2053 Male, age 18, unknown 128665.2
2140 Male, age 76, both hemispheres 125209.2
2272 Male, age 74, both hemispheres 119187.5
Pretectal area
nTPM: 142248.2
1817 Female, age 42, unknown 161740.3
1816 Male, age 51, unknown 160479.8
1944 Female, age 72, unknown 159907.7
2667 Female, age 75, unknown 156266.4
2007 Male, age 72, unknown 152580.7
1815 Male, age 53, unknown 150212.6
2825 Male, age 18, unknown 135070.2
2407 Male, age 75, both hemispheres 126348.6
2316 Male, age 76, right hemisphere 122941.6
2224 Female, age 72, unknown 122158.8
2273 Male, age 74, both hemispheres 117024.2
Red nucleus
nTPM: 143084.4
2584 Male, age 75, left hemisphere 156723.7
2588 Male, age 74, left hemisphere 155775.4
2503 Female, age 72, unknown 148211.9
1954 Female, age 42, unknown 144838.8
2785 Male, age 18, unknown 144300.0
2823 Male, age 76, right hemisphere 140741.0
1821 Female, age 72, unknown 140023.4
2227 Male, age 72, unknown 139793.3
1865 Male, age 51, unknown 139577.0
2769 Male, age 72, unknown 139203.0
1904 Male, age 53, unknown 136896.9
2725 Female, age 75, unknown 130928.4
Substantia nigra
nTPM: 152802.2
2665 Male, age 74, both hemispheres 213391.7
2699 Male, age 18, unknown 156775.4
1916 Female, age 42, unknown 156600.9
2583 Male, age 75, right hemisphere 151130.3
1889 Female, age 72, unknown 148933.8
1941 Male, age 53, unknown 145550.5
1851 Male, age 51, unknown 144475.1
2241 Male, age 72, unknown 142841.3
2590 Female, age 75, unknown 138571.4
2409 Female, age 72, unknown 129751.9
Superior colliculus
nTPM: 140250.3
2664 Male, age 75, both hemispheres 162515.1
2087 Female, age 72, unknown 154244.9
2587 Male, age 74, left hemisphere 139995.7
2668 Female, age 75, unknown 139243.7
2261 Male, age 18, unknown 137771.4
1839 Male, age 51, unknown 135624.2
1913 Female, age 42, unknown 135548.8
1995 Male, age 72, unknown 133803.6
1796 Male, age 53, unknown 132892.2
1895 Male, age 76, right hemisphere 130863.5
Ventral tegmental area
nTPM: 139960.5
2218 Male, age 76, both hemispheres 154732.3
1942 Male, age 51, unknown 141269.3
2223 Female, age 72, unknown 140115.2
1915 Female, age 42, unknown 139188.6
2410 Female, age 72, unknown 133305.7
2021 Male, age 53, unknown 131151.9

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 105565.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 105565.1
Samples: 139

Max nTPM: 471908.1
Min nTPM: 6189.9
Std nTPM: 92119.3
Median nTPM: 76452.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 471908.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 463690.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 453310.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 312792.9
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 309106.6
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 300048.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 290491.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 283600.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 279874.6
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 270044.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 260010.7
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 252479.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 241565.8
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 235793.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 234692.3
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 230497.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 221175.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 221130.3
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 220906.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 213120.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 207444.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 196300.1
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 182770.0
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 175849.1
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 174165.4
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 167464.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 166052.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 165371.0
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 159364.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 157363.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 157241.0
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 154188.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 150808.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 142748.2
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 137402.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 134778.7
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 134270.4
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 134115.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 133357.4
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 128576.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 126532.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 125303.9
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 124825.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 123076.8
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 122293.7
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 110876.9
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 110007.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 109935.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 108814.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 104982.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 103406.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 102657.0
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 102561.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 101745.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 96299.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 95188.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 94996.6
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 91439.5
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 90732.9
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 89057.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 88019.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 86755.9
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 86736.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 85340.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 83321.7
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 81915.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 79575.5
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 79348.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 77228.0
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 76452.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 73189.4
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 73067.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 72999.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 70564.6
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 68158.9
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 68040.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 66207.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 65728.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 64397.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 63773.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 62750.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 60444.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 60205.2
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 58825.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 58117.7
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 57363.9
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 54283.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 51218.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 49641.4
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 49088.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 47651.2
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 47184.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 47113.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 45528.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 44144.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 44089.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 43248.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 42990.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 42197.8
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 41588.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 41147.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 40841.2
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 40192.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 40190.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 37529.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 37442.6
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 36830.0
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 36287.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 36233.8
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 36022.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 35282.4
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 35135.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 34816.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 34762.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 33886.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 33872.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 33723.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 33594.6
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 32345.9
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 31284.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 28306.9
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 27322.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 25730.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 25128.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 25005.3
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 23612.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 23388.0
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 22974.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 21436.5
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 21082.5
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 21012.1
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 18420.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 17593.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 15700.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 14516.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 13444.3
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 12479.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 9674.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 6189.9
Show allShow less

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 73449.3
Pig sample Sample description nTPM
Midbrain
nTPM: 70918.6
Samples: 4

Max nTPM: 87433.7
Min nTPM: 49620.0
Sample A Female 49620.0
Sample B Female 87433.7
Sample C Male 83582.1
Sample D Male 63038.4
Periaqueductal gray
nTPM: 52073.4
Samples: 3

Max nTPM: 63383.1
Min nTPM: 39877.1
Sample B Female 63383.1
Sample C Male 52960.0
Sample D Male 39877.1
Substantia nigra
nTPM: 64470.9
Samples: 4

Max nTPM: 89374.1
Min nTPM: 39404.5
Sample A Female 89374.1
Sample B Female 58199.8
Sample C Male 70905.1
Sample D Male 39404.5
Superior colliculi
nTPM: 73449.3
Samples: 4

Max nTPM: 92293.4
Min nTPM: 48095.4
Sample A Female 81142.7
Sample B Female 48095.4
Sample C Male 92293.4
Sample D Male 72265.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 30959.9
Mouse sample Sample description nTPM
Midbrain
nTPM: 30960.0
Samples: 4

Max nTPM: 32676.1
Min nTPM: 29312.9
Sample A Male 32676.1
Sample B Male 31399.2
Sample C Female 30451.6
Sample D Female 29312.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 24.0
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 24.0
73927706 Antisense, RP_051219_01_F08, Mouse strain C57BL/6J (56 days, male) 24.0
75043148 Antisense, RP_051219_01_F08, Mouse strain C57BL/6J (56 days, male) 22.6

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.