Expression of MT-CO1 in glioma - The Human Protein Atlas

GLIOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

MT-CO1 is not prognostic in glioma

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 5298.67

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

3-year survival highⁱ N/A

3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

6349.1

Number of samples

153

Samples

Sample	Description	FPKM
TCGA-27-1835-01A	53 years, female, white, dead, 648 days	21695.3
TCGA-26-1442-01A	43 years, male, white, alive, 953 days	20210.8
TCGA-06-0141-01A	62 years, male, white, dead, 313 days	18568.7
TCGA-26-5136-01B	78 years, female, white, dead, 577 days	14275.9
TCGA-06-2561-01A	53 years, female, white, dead, 537 days	12391.2
TCGA-26-5134-01A	74 years, male, white, alive, 167 days	12038.0
TCGA-06-0132-01A	49 years, male, white, dead, 771 days	12014.4
TCGA-19-2625-01A	76 years, female, white, dead, 124 days	11638.0
TCGA-27-2519-01A	48 years, male, white, dead, 550 days	11521.6
TCGA-06-0743-01A	69 years, male, white, dead, 803 days	11395.3
TCGA-06-0882-01A	30 years, male, white, dead, 632 days	11377.2
TCGA-32-1980-01A	72 years, male, white, dead, 36 days	11280.0
TCGA-06-1804-01A	81 years, female, white, dead, 414 days	10721.7
TCGA-19-1787-01B	49 years, male, white, dead, 385 days	10235.0
TCGA-19-2620-01A	70 years, male, white, dead, 148 days	9891.7
TCGA-06-0649-01B	73 years, female, black or african american, dead, 64 days	9718.6
TCGA-06-2570-01A	21 years, female, white, alive, 958 days	9713.1
TCGA-15-1444-01A	21 years, male, white, dead, 1537 days	9685.3
TCGA-27-1832-01A	59 years, female, white, dead, 300 days	9637.8
TCGA-27-1837-01A	36 years, male, white, dead, 427 days	9567.4
TCGA-06-0750-01A	43 years, male, white, dead, 28 days	9564.5
TCGA-32-1982-01A	76 years, female, white, dead, 142 days	9496.9
TCGA-06-0238-01A	46 years, male, white, dead, 405 days	9432.7
TCGA-41-4097-01A	63 years, female, white, dead, 6 days	9116.1
TCGA-41-2572-01A	67 years, male, white, dead, 406 days	9086.4
TCGA-06-0168-01A	59 years, female, white, dead, 598 days	8889.0
TCGA-06-0138-01A	43 years, male, white, dead, 737 days	8805.4
TCGA-32-2616-01A	48 years, female, white, dead, 224 days	8786.4
TCGA-28-2499-01A	59 years, male, white, dead, 95 days	8588.2
TCGA-19-1390-01A	63 years, female, white, dead, 772 days	8532.2
TCGA-06-0210-01A	72 years, female, white, dead, 225 days	8472.7
TCGA-16-1045-01B	49 years, female, white, dead, 883 days	8471.8
TCGA-27-1830-01A	57 years, male, white, dead, 154 days	8401.3
TCGA-06-0646-01A	61 years, male, white, dead, 175 days	8383.4
TCGA-06-0219-01A	67 years, male, white, dead, 22 days	8269.0
TCGA-06-2562-01A	81 years, male, white, dead, 382 days	8259.7
TCGA-15-0742-01A	65 years, male, white, dead, 419 days	8253.2
TCGA-06-2558-01A	75 years, female, white, dead, 380 days	8250.0
TCGA-06-0184-01A	63 years, male, white, dead, 2126 days	8085.5
TCGA-06-0156-01A	57 years, male, white, dead, 178 days	8025.0
TCGA-12-0619-01A	60 years, male, white, dead, 1062 days	7951.3
TCGA-19-4065-01A	36 years, male, white, alive, 214 days	7889.7
TCGA-06-5411-01A	51 years, male, white, dead, 254 days	7837.9
TCGA-14-0781-01B	49 years, male, black or african american, dead, 29 days	7785.1
TCGA-28-1753-01A	53 years, male, white, alive, 37 days	7696.0
TCGA-14-1823-01A	58 years, female, white, dead, 543 days	7653.3
TCGA-19-2624-01A	51 years, male, white, dead, 5 days	7628.6
TCGA-16-0846-01A	85 years, male, white, dead, 119 days	7583.5
TCGA-32-1970-01A	59 years, male, white, dead, 468 days	7565.8
TCGA-06-0129-01A	30 years, male, asian, dead, 1024 days	7562.2
TCGA-26-5135-01A	72 years, female, white, dead, 270 days	7540.2
TCGA-06-0744-01A	67 years, male, white, dead, 1426 days	7538.5
TCGA-06-0745-01A	59 years, male, white, dead, 239 days	7384.3
TCGA-06-2557-01A	76 years, male, black or african american, dead, 33 days	7343.4
TCGA-06-0157-01A	63 years, female, white, dead, 97 days	7235.2
TCGA-41-2571-01A	89 years, male, white, dead, 26 days	7220.8
TCGA-08-0386-01A	74 years, male, white, dead, 548 days	7176.4
TCGA-02-0047-01A	78 years, male, white, dead, 448 days	7165.4
TCGA-27-1834-01A	56 years, male, white, dead, 1233 days	6998.0
TCGA-06-0686-01A	53 years, male, white, dead, 432 days	6946.7
TCGA-06-0139-01A	40 years, male, white, dead, 362 days	6935.9
TCGA-32-2634-01A	82 years, male, white, alive, 693 days	6930.6
TCGA-14-0787-01A	69 years, male, asian, dead, 68 days	6711.9
TCGA-12-0616-01A	36 years, female, white, dead, 448 days	6677.3
TCGA-06-0130-01A	54 years, male, white, dead, 394 days	6610.1
TCGA-06-0749-01A	50 years, male, black or african american, dead, 82 days	6534.8
TCGA-06-0187-01A	69 years, male, white, dead, 828 days	6518.7
TCGA-06-0878-01A	74 years, male, white, alive, 218 days	6482.1
TCGA-06-2563-01A	72 years, female, white, alive, 932 days	6450.7
TCGA-14-0871-01A	75 years, female, white, dead, 880 days	6420.4
TCGA-06-2567-01A	65 years, male, white, dead, 133 days	6253.8
TCGA-27-2528-01A	62 years, male, white, dead, 480 days	6244.3
TCGA-32-2615-01A	62 years, male, white, dead, 485 days	6210.3
TCGA-06-0178-01A	39 years, male, white, dead, 2681 days	6194.9
TCGA-06-2564-01A	50 years, male, white, alive, 181 days	6174.2
TCGA-76-4929-01A	76 years, female, white, dead, 111 days	6099.2
TCGA-06-0125-01A	63 years, female, white, dead, 1448 days	6045.7
TCGA-06-0645-01A	56 years, female, white, dead, 175 days	6015.6
TCGA-26-5132-01A	74 years, male, white, alive, 286 days	5975.9
TCGA-26-5139-01A	65 years, female, white, alive, 48 days	5905.8
TCGA-76-4926-01B	68 years, male, white, dead, 138 days	5813.3
TCGA-14-0790-01B	64 years, female, white, dead, 419 days	5758.5
TCGA-19-2619-01A	55 years, female, black or african american, alive, 294 days	5623.6
TCGA-26-5133-01A	59 years, male, white, alive, 452 days	5477.6
TCGA-06-5416-01A	23 years, female, white, alive, 204 days	5378.0
TCGA-06-0190-01A	62 years, male, white, dead, 317 days	5348.8
TCGA-02-2483-01A	43 years, male, asian, alive, 466 days	5311.9
TCGA-14-0789-01A	54 years, male, white, dead, 342 days	5285.4
TCGA-14-1034-01A	60 years, female, dead, 485 days	5272.8
TCGA-32-2632-01A	80 years, male, white, dead, 269 days	5241.6
TCGA-28-2513-01A	69 years, female, white, alive, 222 days	5161.7
TCGA-76-4925-01A	76 years, male, white, dead, 146 days	5159.6
TCGA-32-2638-01A	67 years, male, white, dead, 766 days	5103.5
TCGA-14-1825-01A	70 years, male, white, dead, 232 days	5050.0
TCGA-06-5412-01A	78 years, female, white, dead, 138 days	4981.3
TCGA-28-1747-01C	44 years, male, white, dead, 77 days	4967.9
TCGA-06-5858-01A	45 years, female, white, alive, 187 days	4915.1
TCGA-28-2514-01A	45 years, male, asian, alive, 160 days	4895.8
TCGA-06-0747-01A	53 years, male, white, dead, 82 days	4853.3
TCGA-32-4213-01A	47 years, female, white, alive, 604 days	4814.9
TCGA-06-0158-01A	73 years, male, white, dead, 329 days	4773.3
TCGA-12-0821-01A	62 years, male, white, dead, 323 days	4682.8
TCGA-06-2559-01A	83 years, male, white, dead, 150 days	4647.9
TCGA-27-2521-01A	34 years, male, white, dead, 510 days	4591.9
TCGA-76-4928-01B	85 years, female, white, dead, 94 days	4498.2
TCGA-14-0817-01A	69 years, female, white, dead, 164 days	4449.4
TCGA-28-5218-01A	63 years, male, white, dead, 157 days	4363.8
TCGA-06-5418-01A	75 years, female, white, dead, 83 days	4277.2
TCGA-12-0618-01A	49 years, male, white, dead, 395 days	4276.4
TCGA-41-3915-01A	48 years, male, white, dead, 360 days	4083.2
TCGA-27-2524-01A	56 years, male, white, dead, 231 days	4074.3
TCGA-12-1597-01B	62 years, female, white, dead, 675 days	4047.7
TCGA-28-5216-01A	52 years, male, white, alive, 415 days	4018.2
TCGA-06-2565-01A	59 years, male, asian, dead, 506 days	3947.5
TCGA-06-5417-01A	45 years, female, white, alive, 155 days	3901.9
TCGA-28-5207-01A	71 years, male, white, dead, 343 days	3890.8
TCGA-19-2629-01A	60 years, male, white, dead, 737 days	3864.1
TCGA-06-5410-01A	72 years, female, white, dead, 108 days	3851.2
TCGA-28-5215-01A	62 years, female, white, dead, 335 days	3832.3
TCGA-27-2526-01A	79 years, female, white, dead, 87 days	3684.3
TCGA-76-4931-01A	70 years, female, white, dead, 279 days	3634.1
TCGA-76-4932-01A	50 years, female, white, dead, 1458 days	3534.3
TCGA-19-5960-01A	56 years, male, white, dead, 455 days	3520.0
TCGA-76-4927-01A	58 years, male, white, dead, 535 days	3475.2
TCGA-06-0644-01A	71 years, male, black or african american, dead, 384 days	3464.3
TCGA-28-2509-01A	77 years, female, white, alive, 145 days	3409.1
TCGA-27-1831-01A	66 years, male, white, dead, 505 days	3294.6
TCGA-06-0174-01A	54 years, male, white, dead, 98 days	3242.8
TCGA-28-5220-01A	67 years, male, white, dead, 388 days	3219.5
TCGA-02-0055-01A	62 years, female, white, dead, 76 days	3189.0
TCGA-06-0211-01B	47 years, male, white, dead, 360 days	3169.6
TCGA-06-5414-01A	61 years, male, white, alive, 273 days	3079.7
TCGA-14-1829-01A	57 years, male, black or african american, alive, 218 days	3074.2
TCGA-14-2554-01A	52 years, female, white, dead, 532 days	3050.8
TCGA-28-5209-01A	66 years, female, white, alive, 77 days	2990.4
TCGA-27-2523-01A	63 years, male, white, dead, 489 days	2940.8
TCGA-41-5651-01A	59 years, female, black or african american, dead, 460 days	2917.9
TCGA-06-5856-01A	58 years, male, white, dead, 114 days	2709.5
TCGA-06-2569-01A	24 years, female, black or african american, alive, 13 days	2456.4
TCGA-12-3653-01A	34 years, female, white, dead, 442 days	2327.1
TCGA-06-5408-01A	54 years, female, white, dead, 357 days	2192.0
TCGA-06-5413-01A	67 years, male, white, alive, 268 days	2175.8
TCGA-12-3650-01A	46 years, male, white, dead, 333 days	2111.7
TCGA-06-5859-01A	63 years, male, white, alive, 139 days	2059.7
TCGA-12-3652-01A	60 years, male, white, dead, 1062 days	2048.8
TCGA-02-2485-01A	53 years, male, black or african american, alive, 470 days	2042.8
TCGA-12-5299-01A	56 years, female, white, dead, 98 days	1912.5
TCGA-28-5204-01A	72 years, male, white, dead, 454 days	1852.8
TCGA-28-5208-01A	52 years, male, white, dead, 544 days	1699.6
TCGA-12-5295-01A	60 years, female, white, dead, 454 days	1341.6
TCGA-28-5213-01A	72 years, male, white, alive, 951 days	1256.6
TCGA-32-5222-01A	66 years, male, white, dead, 585 days	1240.2
TCGA-02-2486-01A	64 years, male, white, dead, 618 days	776.7
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GLIOMA - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample. Read more	Antibody HPA069328	Antibody CAB016241
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details