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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:103274.0 nTPM
HPA:103274.0 nTPM
GTEx:97268.8 nTPM
Pig:37694.2 nTPM
Mouse:28656.2 nTPM
Allen mouse:23.9 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 103274.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 96856.3
2586 Male, age 75, left hemisphere 111354.1
2666 Male, age 74, left hemisphere 103419.3
2219 Male, age 76, both hemispheres 101930.5
2828 Female, age 72, unknown 100335.4
1870 Female, age 42, unknown 95117.5
1833 Male, age 53, unknown 94456.0
1830 Male, age 51, unknown 92283.8
1827 Male, age 72, unknown 91770.1
2019 Male, age 18, unknown 91362.1
2411 Female, age 72, unknown 86534.4
Dorsal raphe nucleus
nTPM: 90462.7
1828 Male, age 53, unknown 94674.5
2047 Male, age 72, unknown 92507.2
2750 Male, age 76, both hemispheres 91000.6
2016 Female, age 72, unknown 89382.2
2298 Female, age 72, unknown 84748.9
Inferior colliculus
nTPM: 92337.8
2849 Male, age 72, unknown 97588.0
1890 Male, age 53, unknown 93694.0
1848 Female, age 42, unknown 91539.5
2097 Female, age 72, unknown 86529.8
Median raphe nucleus
nTPM: 103274.0
2220 Male, age 76, midline 103274.0
Pedunculopontine tegmental nucleus
nTPM: 95380.2
2334 Male, age 80, both hemispheres 102192.0
2338 Male, age 61, both hemispheres 94384.8
1921 Female, age 85, both hemispheres 89563.7
Periaquaductal grey, anterior
nTPM: 90383.8
2502 Female, age 75, unknown 92630.1
1795 Male, age 51, unknown 90108.6
1947 Male, age 18, unknown 88412.8
Periaquaductal grey, dorsal
nTPM: 92861.7
2850 Male, age 76, both hemispheres 100028.3
1831 Male, age 72, unknown 91613.4
1840 Male, age 53, unknown 90346.1
2464 Female, age 72, unknown 89458.9
Periaquaductal grey, lateral
nTPM: 87780.4
2140 Male, age 76, both hemispheres 89362.3
2053 Male, age 18, unknown 89174.2
2272 Male, age 74, both hemispheres 84804.8
Pretectal area
nTPM: 94765.7
2667 Female, age 75, unknown 103225.2
1816 Male, age 51, unknown 101837.7
1944 Female, age 72, unknown 101554.1
1817 Female, age 42, unknown 101505.1
2007 Male, age 72, unknown 98027.6
1815 Male, age 53, unknown 97623.4
2825 Male, age 18, unknown 92046.7
2407 Male, age 75, both hemispheres 89625.3
2224 Female, age 72, unknown 87292.3
2316 Male, age 76, right hemisphere 85879.3
2273 Male, age 74, both hemispheres 83806.3
Red nucleus
nTPM: 93749.3
2584 Male, age 75, left hemisphere 101294.5
2588 Male, age 74, left hemisphere 97316.1
2503 Female, age 72, unknown 95514.2
2785 Male, age 18, unknown 95172.1
1954 Female, age 42, unknown 94389.6
1865 Male, age 51, unknown 93484.7
2823 Male, age 76, right hemisphere 92347.9
2227 Male, age 72, unknown 91626.1
2769 Male, age 72, unknown 91506.5
1904 Male, age 53, unknown 91487.6
1821 Female, age 72, unknown 91368.1
2725 Female, age 75, unknown 89484.6
Substantia nigra
nTPM: 98132.5
2665 Male, age 74, both hemispheres 116494.1
2699 Male, age 18, unknown 105356.2
1916 Female, age 42, unknown 104345.1
1889 Female, age 72, unknown 96528.5
1941 Male, age 53, unknown 96175.8
2583 Male, age 75, right hemisphere 95483.1
2241 Male, age 72, unknown 95238.3
1851 Male, age 51, unknown 93362.2
2590 Female, age 75, unknown 90844.0
2409 Female, age 72, unknown 87497.6
Superior colliculus
nTPM: 93699.6
2664 Male, age 75, both hemispheres 105966.0
2087 Female, age 72, unknown 97723.2
2587 Male, age 74, left hemisphere 94797.5
2668 Female, age 75, unknown 92788.0
1913 Female, age 42, unknown 92317.0
2261 Male, age 18, unknown 91073.8
1839 Male, age 51, unknown 91015.5
1796 Male, age 53, unknown 90793.4
1895 Male, age 76, right hemisphere 90312.1
1995 Male, age 72, unknown 90209.7
Ventral tegmental area
nTPM: 93964.2
2218 Male, age 76, both hemispheres 101952.5
1942 Male, age 51, unknown 94919.8
2223 Female, age 72, unknown 94387.7
1915 Female, age 42, unknown 94318.2
2021 Male, age 53, unknown 90522.8
2410 Female, age 72, unknown 87684.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 97268.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 97268.8
Samples: 139

Max nTPM: 357446.4
Min nTPM: 6701.8
Std nTPM: 66324.9
Median nTPM: 74350.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 357446.4
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 349191.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 307581.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 284710.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 270412.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 250319.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 238891.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 224783.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 219267.3
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 215771.2
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 214599.7
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 209646.0
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 194193.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 191858.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 188021.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 180268.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 177061.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 176830.1
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 176005.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 172007.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 168434.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 162997.0
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 160582.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 157753.6
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 149114.6
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 143309.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 136759.4
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 136681.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 132973.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 126071.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 123263.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 123255.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 122233.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 116917.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 116034.8
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 115294.3
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 113361.2
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 111770.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 111570.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 110841.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 109881.4
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 107465.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 107417.0
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 106991.8
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 103827.9
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 103005.8
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 101822.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 99638.6
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 97248.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 96592.6
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 96589.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 93780.2
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 93683.2
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 91870.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 91638.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 91139.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 87217.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 86666.1
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 86393.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 85732.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 85599.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 84563.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 82163.5
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 81671.7
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 79602.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 79399.4
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 78792.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 78516.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 76455.2
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 74350.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 74299.4
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 74057.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 73613.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 73311.5
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 72834.8
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 72564.5
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 72481.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 70629.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 70600.5
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 69665.9
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 68824.0
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 67163.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 66267.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 65865.4
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 65608.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 64928.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 64442.0
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 64319.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 61772.7
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 61336.8
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 61228.2
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 60940.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 60563.6
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 59074.5
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 58978.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 58802.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 58434.6
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 57078.2
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 56889.9
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 56875.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 55198.8
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 54917.4
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 54833.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 54642.9
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 54624.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 54428.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 54381.5
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 53705.0
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 52221.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 52158.1
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 49805.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 49425.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 49319.1
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 49296.9
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 47393.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 47108.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 44905.5
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 43809.5
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 43609.1
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 43508.3
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 40832.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 40594.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 39779.8
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 36851.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 35477.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 34884.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 34736.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 33728.5
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 32358.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 32105.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 28035.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 27632.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 25954.8
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 25729.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 24851.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 24389.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 23799.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 21368.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 6701.8
Show allShow less

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 37694.2
Pig sample Sample description nTPM
Midbrain
nTPM: 37694.2
Samples: 4

Max nTPM: 49920.4
Min nTPM: 29570.5
Sample A Female 29792.7
Sample B Female 49920.4
Sample C Male 41493.1
Sample D Male 29570.5
Periaqueductal gray
nTPM: 29590.1
Samples: 3

Max nTPM: 35387.4
Min nTPM: 23655.5
Sample B Female 35387.4
Sample C Male 29727.4
Sample D Male 23655.5
Substantia nigra
nTPM: 31600.9
Samples: 4

Max nTPM: 36488.0
Min nTPM: 22798.7
Sample A Female 36488.0
Sample B Female 30917.1
Sample C Male 36199.7
Sample D Male 22798.7
Superior colliculi
nTPM: 32175.2
Samples: 4

Max nTPM: 42181.1
Min nTPM: 11344.6
Sample A Female 36408.1
Sample B Female 11344.6
Sample C Male 42181.1
Sample D Male 38767.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 28656.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 28656.2
Samples: 4

Max nTPM: 29161.8
Min nTPM: 28233.4
Sample A Male 29161.8
Sample B Male 28233.4
Sample C Female 28669.3
Sample D Female 28560.2

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 23.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 23.9
81600592 Antisense, RP_090205_01_D01, Mouse strain C57BL/6J (56 days, male) 24.3
74357761 Antisense, RP_051219_04_A05, Mouse strain C57BL/6J (56 days, male) 23.5

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.