Expression of MT-CO3 in glioma - The Human Protein Atlas

GLIOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

MT-CO3 is not prognostic in glioma

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 6322.43

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

3-year survival highⁱ N/A

3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

5270.2

Number of samples

153

Samples

Sample	Description	FPKM
TCGA-06-0141-01A	62 years, male, white, dead, 313 days	21167.0
TCGA-06-0238-01A	46 years, male, white, dead, 405 days	14260.6
TCGA-27-1835-01A	53 years, female, white, dead, 648 days	13126.6
TCGA-26-1442-01A	43 years, male, white, alive, 953 days	11377.5
TCGA-06-0743-01A	69 years, male, white, dead, 803 days	11354.1
TCGA-06-0649-01B	73 years, female, black or african american, dead, 64 days	11164.9
TCGA-14-1823-01A	58 years, female, white, dead, 543 days	10245.6
TCGA-06-2561-01A	53 years, female, white, dead, 537 days	10158.9
TCGA-06-0744-01A	67 years, male, white, dead, 1426 days	10065.9
TCGA-06-0184-01A	63 years, male, white, dead, 2126 days	9760.1
TCGA-32-1980-01A	72 years, male, white, dead, 36 days	9529.6
TCGA-06-0132-01A	49 years, male, white, dead, 771 days	9456.2
TCGA-06-0138-01A	43 years, male, white, dead, 737 days	8714.8
TCGA-32-1982-01A	76 years, female, white, dead, 142 days	8629.6
TCGA-27-1830-01A	57 years, male, white, dead, 154 days	8613.1
TCGA-06-0750-01A	43 years, male, white, dead, 28 days	8534.8
TCGA-06-0882-01A	30 years, male, white, dead, 632 days	8348.0
TCGA-12-0616-01A	36 years, female, white, dead, 448 days	8177.6
TCGA-19-2625-01A	76 years, female, white, dead, 124 days	8175.5
TCGA-06-0219-01A	67 years, male, white, dead, 22 days	8003.4
TCGA-14-0871-01A	75 years, female, white, dead, 880 days	7993.8
TCGA-06-1804-01A	81 years, female, white, dead, 414 days	7979.4
TCGA-27-1837-01A	36 years, male, white, dead, 427 days	7937.5
TCGA-27-2519-01A	48 years, male, white, dead, 550 days	7847.2
TCGA-06-0646-01A	61 years, male, white, dead, 175 days	7844.8
TCGA-06-0210-01A	72 years, female, white, dead, 225 days	7804.2
TCGA-06-2570-01A	21 years, female, white, alive, 958 days	7685.1
TCGA-27-1832-01A	59 years, female, white, dead, 300 days	7628.9
TCGA-06-0749-01A	50 years, male, black or african american, dead, 82 days	7570.2
TCGA-32-2616-01A	48 years, female, white, dead, 224 days	7497.0
TCGA-26-5136-01B	78 years, female, white, dead, 577 days	7335.1
TCGA-19-2620-01A	70 years, male, white, dead, 148 days	7325.3
TCGA-06-0168-01A	59 years, female, white, dead, 598 days	7308.8
TCGA-19-4065-01A	36 years, male, white, alive, 214 days	7303.4
TCGA-02-2483-01A	43 years, male, asian, alive, 466 days	7293.2
TCGA-26-5132-01A	74 years, male, white, alive, 286 days	7205.8
TCGA-14-0781-01B	49 years, male, black or african american, dead, 29 days	7170.3
TCGA-26-5134-01A	74 years, male, white, alive, 167 days	7166.8
TCGA-06-2558-01A	75 years, female, white, dead, 380 days	7141.3
TCGA-19-1787-01B	49 years, male, white, dead, 385 days	7024.9
TCGA-06-0157-01A	63 years, female, white, dead, 97 days	6799.1
TCGA-27-2528-01A	62 years, male, white, dead, 480 days	6726.5
TCGA-06-2562-01A	81 years, male, white, dead, 382 days	6617.9
TCGA-06-0178-01A	39 years, male, white, dead, 2681 days	6592.8
TCGA-32-1970-01A	59 years, male, white, dead, 468 days	6535.2
TCGA-15-0742-01A	65 years, male, white, dead, 419 days	6431.1
TCGA-19-1390-01A	63 years, female, white, dead, 772 days	6425.9
TCGA-28-1753-01A	53 years, male, white, alive, 37 days	6418.1
TCGA-16-0846-01A	85 years, male, white, dead, 119 days	6347.8
TCGA-12-0619-01A	60 years, male, white, dead, 1062 days	6346.5
TCGA-06-0139-01A	40 years, male, white, dead, 362 days	6298.3
TCGA-32-2632-01A	80 years, male, white, dead, 269 days	6252.9
TCGA-14-0787-01A	69 years, male, asian, dead, 68 days	6195.6
TCGA-26-5135-01A	72 years, female, white, dead, 270 days	6192.4
TCGA-06-0686-01A	53 years, male, white, dead, 432 days	6151.8
TCGA-06-0745-01A	59 years, male, white, dead, 239 days	6092.5
TCGA-14-0817-01A	69 years, female, white, dead, 164 days	5767.6
TCGA-32-2634-01A	82 years, male, white, alive, 693 days	5718.4
TCGA-41-4097-01A	63 years, female, white, dead, 6 days	5698.0
TCGA-06-0156-01A	57 years, male, white, dead, 178 days	5604.6
TCGA-06-0130-01A	54 years, male, white, dead, 394 days	5497.1
TCGA-06-5411-01A	51 years, male, white, dead, 254 days	5465.6
TCGA-19-2624-01A	51 years, male, white, dead, 5 days	5331.7
TCGA-02-0047-01A	78 years, male, white, dead, 448 days	5307.3
TCGA-16-1045-01B	49 years, female, white, dead, 883 days	5255.3
TCGA-26-5133-01A	59 years, male, white, alive, 452 days	5170.9
TCGA-06-0158-01A	73 years, male, white, dead, 329 days	5167.2
TCGA-06-0645-01A	56 years, female, white, dead, 175 days	5109.7
TCGA-27-1834-01A	56 years, male, white, dead, 1233 days	5088.0
TCGA-08-0386-01A	74 years, male, white, dead, 548 days	4996.5
TCGA-06-2557-01A	76 years, male, black or african american, dead, 33 days	4985.0
TCGA-41-2571-01A	89 years, male, white, dead, 26 days	4879.3
TCGA-28-2513-01A	69 years, female, white, alive, 222 days	4828.8
TCGA-27-2524-01A	56 years, male, white, dead, 231 days	4817.2
TCGA-06-0878-01A	74 years, male, white, alive, 218 days	4815.2
TCGA-15-1444-01A	21 years, male, white, dead, 1537 days	4815.0
TCGA-06-5416-01A	23 years, female, white, alive, 204 days	4739.1
TCGA-27-1831-01A	66 years, male, white, dead, 505 days	4701.8
TCGA-06-0190-01A	62 years, male, white, dead, 317 days	4649.3
TCGA-06-2564-01A	50 years, male, white, alive, 181 days	4596.1
TCGA-41-2572-01A	67 years, male, white, dead, 406 days	4578.4
TCGA-28-2499-01A	59 years, male, white, dead, 95 days	4578.0
TCGA-06-5858-01A	45 years, female, white, alive, 187 days	4496.9
TCGA-06-0129-01A	30 years, male, asian, dead, 1024 days	4496.1
TCGA-27-2521-01A	34 years, male, white, dead, 510 days	4462.7
TCGA-14-1829-01A	57 years, male, black or african american, alive, 218 days	4428.5
TCGA-76-4926-01B	68 years, male, white, dead, 138 days	4351.6
TCGA-06-5417-01A	45 years, female, white, alive, 155 days	4350.2
TCGA-06-0125-01A	63 years, female, white, dead, 1448 days	4349.8
TCGA-19-2619-01A	55 years, female, black or african american, alive, 294 days	4267.2
TCGA-14-0790-01B	64 years, female, white, dead, 419 days	4263.9
TCGA-28-5218-01A	63 years, male, white, dead, 157 days	4200.7
TCGA-06-5412-01A	78 years, female, white, dead, 138 days	4057.2
TCGA-12-1597-01B	62 years, female, white, dead, 675 days	4009.9
TCGA-14-1825-01A	70 years, male, white, dead, 232 days	4003.2
TCGA-76-4929-01A	76 years, female, white, dead, 111 days	3984.7
TCGA-76-4928-01B	85 years, female, white, dead, 94 days	3963.8
TCGA-06-2563-01A	72 years, female, white, alive, 932 days	3883.8
TCGA-06-0187-01A	69 years, male, white, dead, 828 days	3850.1
TCGA-28-2514-01A	45 years, male, asian, alive, 160 days	3758.8
TCGA-27-2526-01A	79 years, female, white, dead, 87 days	3746.9
TCGA-32-4213-01A	47 years, female, white, alive, 604 days	3718.4
TCGA-12-0821-01A	62 years, male, white, dead, 323 days	3686.6
TCGA-41-3915-01A	48 years, male, white, dead, 360 days	3670.7
TCGA-32-2615-01A	62 years, male, white, dead, 485 days	3647.5
TCGA-14-0789-01A	54 years, male, white, dead, 342 days	3639.9
TCGA-06-2559-01A	83 years, male, white, dead, 150 days	3561.2
TCGA-14-1034-01A	60 years, female, dead, 485 days	3551.3
TCGA-06-0747-01A	53 years, male, white, dead, 82 days	3498.7
TCGA-12-0618-01A	49 years, male, white, dead, 395 days	3447.5
TCGA-26-5139-01A	65 years, female, white, alive, 48 days	3440.1
TCGA-14-2554-01A	52 years, female, white, dead, 532 days	3334.9
TCGA-19-2629-01A	60 years, male, white, dead, 737 days	3315.2
TCGA-06-2565-01A	59 years, male, asian, dead, 506 days	3308.6
TCGA-32-2638-01A	67 years, male, white, dead, 766 days	3282.8
TCGA-06-5418-01A	75 years, female, white, dead, 83 days	3230.4
TCGA-06-2567-01A	65 years, male, white, dead, 133 days	3229.1
TCGA-76-4932-01A	50 years, female, white, dead, 1458 days	3169.4
TCGA-76-4925-01A	76 years, male, white, dead, 146 days	3093.7
TCGA-06-0174-01A	54 years, male, white, dead, 98 days	3051.0
TCGA-06-0644-01A	71 years, male, black or african american, dead, 384 days	3042.2
TCGA-02-0055-01A	62 years, female, white, dead, 76 days	3013.2
TCGA-28-2509-01A	77 years, female, white, alive, 145 days	3000.0
TCGA-28-5207-01A	71 years, male, white, dead, 343 days	2994.5
TCGA-28-5216-01A	52 years, male, white, alive, 415 days	2972.1
TCGA-28-1747-01C	44 years, male, white, dead, 77 days	2832.3
TCGA-06-2569-01A	24 years, female, black or african american, alive, 13 days	2816.2
TCGA-06-0211-01B	47 years, male, white, dead, 360 days	2808.4
TCGA-19-5960-01A	56 years, male, white, dead, 455 days	2718.9
TCGA-41-5651-01A	59 years, female, black or african american, dead, 460 days	2717.0
TCGA-27-2523-01A	63 years, male, white, dead, 489 days	2500.0
TCGA-76-4931-01A	70 years, female, white, dead, 279 days	2465.0
TCGA-06-5410-01A	72 years, female, white, dead, 108 days	2412.0
TCGA-28-5215-01A	62 years, female, white, dead, 335 days	2357.2
TCGA-28-5220-01A	67 years, male, white, dead, 388 days	2314.0
TCGA-76-4927-01A	58 years, male, white, dead, 535 days	2295.9
TCGA-06-5414-01A	61 years, male, white, alive, 273 days	2175.5
TCGA-06-5856-01A	58 years, male, white, dead, 114 days	2081.4
TCGA-12-3650-01A	46 years, male, white, dead, 333 days	2038.5
TCGA-02-2485-01A	53 years, male, black or african american, alive, 470 days	1935.1
TCGA-28-5209-01A	66 years, female, white, alive, 77 days	1881.6
TCGA-06-5413-01A	67 years, male, white, alive, 268 days	1672.6
TCGA-06-5408-01A	54 years, female, white, dead, 357 days	1547.3
TCGA-12-3652-01A	60 years, male, white, dead, 1062 days	1519.0
TCGA-28-5208-01A	52 years, male, white, dead, 544 days	1502.1
TCGA-12-5295-01A	60 years, female, white, dead, 454 days	1485.0
TCGA-12-5299-01A	56 years, female, white, dead, 98 days	1447.6
TCGA-06-5859-01A	63 years, male, white, alive, 139 days	1339.9
TCGA-12-3653-01A	34 years, female, white, dead, 442 days	1179.5
TCGA-32-5222-01A	66 years, male, white, dead, 585 days	1126.4
TCGA-28-5204-01A	72 years, male, white, dead, 454 days	957.4
TCGA-02-2486-01A	64 years, male, white, dead, 618 days	947.5
TCGA-28-5213-01A	72 years, male, white, alive, 951 days	931.1
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GLIOMA - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample. Read more	Antibody HPA042788
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details