GENERAL INFORMATIONi
Gene namei DCTN1
Synonyms
Gene descriptioni Dynactin subunit 1
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 2
Cytoband p13.1
Chromosome location (bp) 74361154 - 74392087
Number of transcriptsi 17
Ensembl ENSG00000204843 (version 103.38)
Entrez gene 1639
HGNC HGNC:2711
UniProt Q14203 (UniProt - Evidence at protein level)
neXtProt NX_Q14203
Antibodypedia DCTN1 antibodies


PROTEIN STRUCTUREi

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 12      # Population variants: 758

Antigens:

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Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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PROTEIN BROWSERi
«
DCTN1-201
DCTN1-202
DCTN1-203
DCTN1-204
DCTN1-205
DCTN1-206
DCTN1-207
DCTN1-208
DCTN1-209
DCTN1-211
DCTN1-212
DCTN1-213
DCTN1-214
DCTN1-215
DCTN1-226
DCTN1-227
DCTN1-228
»


PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
DCTN1-201
ENSP00000354791
ENST00000361874
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005938 [cell cortex]
GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0008017 [microtubule binding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010457 [centriole-centriole cohesion]
GO:0010970 [transport along microtubule]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030904 [retromer complex]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0034454 [microtubule anchoring at centrosome]
GO:0035371 [microtubule plus-end]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045171 [intercellular bridge]
GO:0048156 [tau protein binding]
GO:0050905 [neuromuscular process]
GO:0051010 [microtubule plus-end binding]
GO:0051081 [nuclear envelope disassembly]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061744 [motor behavior]
GO:0070050 [neuron cellular homeostasis]
GO:0072686 [mitotic spindle]
GO:0090063 [positive regulation of microtubule nucleation]
GO:0097711 [ciliary basal body-plasma membrane docking]
GO:0099558 [maintenance of synapse structure]
GO:0099738 [cell cortex region]
GO:0120103 [centriolar subdistal appendage]
GO:1904398 [positive regulation of neuromuscular junction development]
GO:1905515 [non-motile cilium assembly]
GO:1990535 [neuron projection maintenance]
Show all
 1273 aa
141 kDa 		No 0
DCTN1-202
ENSP00000377571
ENST00000394003
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005938 [cell cortex]
GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0008017 [microtubule binding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010457 [centriole-centriole cohesion]
GO:0010970 [transport along microtubule]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030904 [retromer complex]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0034454 [microtubule anchoring at centrosome]
GO:0035371 [microtubule plus-end]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045171 [intercellular bridge]
GO:0048156 [tau protein binding]
GO:0050905 [neuromuscular process]
GO:0051010 [microtubule plus-end binding]
GO:0051081 [nuclear envelope disassembly]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061744 [motor behavior]
GO:0070050 [neuron cellular homeostasis]
GO:0072686 [mitotic spindle]
GO:0090063 [positive regulation of microtubule nucleation]
GO:0097711 [ciliary basal body-plasma membrane docking]
GO:0099558 [maintenance of synapse structure]
GO:0099738 [cell cortex region]
GO:0120103 [centriolar subdistal appendage]
GO:1904398 [positive regulation of neuromuscular junction development]
GO:1905515 [non-motile cilium assembly]
GO:1990535 [neuron projection maintenance]
Show all
 1271 aa
140.9 kDa 		No 0
DCTN1-203
ENSP00000386406
ENST00000409240
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005938 [cell cortex]
GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0008017 [microtubule binding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010457 [centriole-centriole cohesion]
GO:0010970 [transport along microtubule]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030904 [retromer complex]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0034454 [microtubule anchoring at centrosome]
GO:0035371 [microtubule plus-end]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045171 [intercellular bridge]
GO:0048156 [tau protein binding]
GO:0050905 [neuromuscular process]
GO:0051010 [microtubule plus-end binding]
GO:0051081 [nuclear envelope disassembly]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061744 [motor behavior]
GO:0070050 [neuron cellular homeostasis]
GO:0072686 [mitotic spindle]
GO:0090063 [positive regulation of microtubule nucleation]
GO:0097711 [ciliary basal body-plasma membrane docking]
GO:0099558 [maintenance of synapse structure]
GO:0099738 [cell cortex region]
GO:0120103 [centriolar subdistal appendage]
GO:1904398 [positive regulation of neuromuscular junction development]
GO:1905515 [non-motile cilium assembly]
GO:1990535 [neuron projection maintenance]
Show all
 1236 aa
136.8 kDa 		No 0
DCTN1-204
ENSP00000387270
ENST00000409438
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005938 [cell cortex]
GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0008017 [microtubule binding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010457 [centriole-centriole cohesion]
GO:0010970 [transport along microtubule]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030904 [retromer complex]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0034454 [microtubule anchoring at centrosome]
GO:0035371 [microtubule plus-end]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045171 [intercellular bridge]
GO:0048156 [tau protein binding]
GO:0050905 [neuromuscular process]
GO:0051010 [microtubule plus-end binding]
GO:0051081 [nuclear envelope disassembly]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061744 [motor behavior]
GO:0070050 [neuron cellular homeostasis]
GO:0072686 [mitotic spindle]
GO:0090063 [positive regulation of microtubule nucleation]
GO:0097711 [ciliary basal body-plasma membrane docking]
GO:0099558 [maintenance of synapse structure]
GO:0099738 [cell cortex region]
GO:0120103 [centriolar subdistal appendage]
GO:1904398 [positive regulation of neuromuscular junction development]
GO:1905515 [non-motile cilium assembly]
GO:1990535 [neuron projection maintenance]
Show all
 1139 aa
126.7 kDa 		No 0
DCTN1-205
ENSP00000386843
ENST00000409567
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005938 [cell cortex]
GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0008017 [microtubule binding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010457 [centriole-centriole cohesion]
GO:0010970 [transport along microtubule]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030904 [retromer complex]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0034454 [microtubule anchoring at centrosome]
GO:0035371 [microtubule plus-end]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045171 [intercellular bridge]
GO:0048156 [tau protein binding]
GO:0050905 [neuromuscular process]
GO:0051010 [microtubule plus-end binding]
GO:0051081 [nuclear envelope disassembly]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061744 [motor behavior]
GO:0070050 [neuron cellular homeostasis]
GO:0072686 [mitotic spindle]
GO:0090063 [positive regulation of microtubule nucleation]
GO:0097711 [ciliary basal body-plasma membrane docking]
GO:0099558 [maintenance of synapse structure]
GO:0099738 [cell cortex region]
GO:0120103 [centriolar subdistal appendage]
GO:1904398 [positive regulation of neuromuscular junction development]
GO:1905515 [non-motile cilium assembly]
GO:1990535 [neuron projection maintenance]
Show all
 1253 aa
138.8 kDa 		No 0
DCTN1-206
ENSP00000387327
ENST00000409868
E7EX90 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0003774 [motor activity]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005856 [cytoskeleton]
GO:0007049 [cell cycle]
GO:0008017 [microtubule binding]
GO:0010970 [transport along microtubule]
GO:0015630 [microtubule cytoskeleton]
GO:0030286 [dynein complex]
GO:0045171 [intercellular bridge]
GO:0051301 [cell division]
GO:0072686 [mitotic spindle]
Show all
 1256 aa
139.1 kDa 		No 0
DCTN1-207
ENSP00000413268
ENST00000413111
C9JZA4 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.1 kDa 		No 0
DCTN1-208
ENSP00000402509
ENST00000417090
C9JKG6 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0005813 [centrosome]
GO:0008017 [microtubule binding]
GO:0010970 [transport along microtubule]
Show all
 135 aa
14.4 kDa 		No 0
DCTN1-209
ENSP00000409363
ENST00000421392
C9JTE5 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.1 kDa 		No 0
DCTN1-211
ENSP00000395312
ENST00000437375
C9JJN7 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 87 aa
9.3 kDa 		No 0
DCTN1-212
ENSP00000400059
ENST00000440727
C9J1B7 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
6.8 kDa 		No 0
DCTN1-213
ENSP00000407484
ENST00000449655
C9JUI8 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 13 aa
1.3 kDa 		No 0
DCTN1-214
ENSP00000404038
ENST00000454119
C9JJD0 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0005813 [centrosome]
GO:0008017 [microtubule binding]
GO:0010970 [transport along microtubule]
Show all
 121 aa
12.9 kDa 		No 0
DCTN1-215
ENSP00000414315
ENST00000458655
E9PCY0 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0005813 [centrosome]
GO:0008017 [microtubule binding]
GO:0010970 [transport along microtubule]
Show all
 186 aa
19.5 kDa 		No 0
DCTN1-226
ENSP00000487279
ENST00000628224
E7EX90 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0003774 [motor activity]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005856 [cytoskeleton]
GO:0007049 [cell cycle]
GO:0008017 [microtubule binding]
GO:0010970 [transport along microtubule]
GO:0015630 [microtubule cytoskeleton]
GO:0030286 [dynein complex]
GO:0045171 [intercellular bridge]
GO:0051301 [cell division]
GO:0072686 [mitotic spindle]
Show all
 1278 aa
141.7 kDa 		No 0
DCTN1-227
ENSP00000487724
ENST00000633691
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005938 [cell cortex]
GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport]
GO:0007049 [cell cycle]
GO:0007097 [nuclear migration]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0008017 [microtubule binding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010457 [centriole-centriole cohesion]
GO:0010970 [transport along microtubule]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030904 [retromer complex]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0034454 [microtubule anchoring at centrosome]
GO:0035371 [microtubule plus-end]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045171 [intercellular bridge]
GO:0048156 [tau protein binding]
GO:0050905 [neuromuscular process]
GO:0051010 [microtubule plus-end binding]
GO:0051081 [nuclear envelope disassembly]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061744 [motor behavior]
GO:0070050 [neuron cellular homeostasis]
GO:0072686 [mitotic spindle]
GO:0090063 [positive regulation of microtubule nucleation]
GO:0097711 [ciliary basal body-plasma membrane docking]
GO:0099558 [maintenance of synapse structure]
GO:0099738 [cell cortex region]
GO:0120103 [centriolar subdistal appendage]
GO:1904398 [positive regulation of neuromuscular junction development]
GO:1905515 [non-motile cilium assembly]
GO:1990535 [neuron projection maintenance]
Show all
 1144 aa
127.4 kDa 		No 0
DCTN1-228
ENSP00000505612
ENST00000680606
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0005813 [centrosome]
GO:0008017 [microtubule binding]
GO:0010970 [transport along microtubule]
Show all
 1261 aa
139.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.