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The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
HPA001245
Malignant: Irregular cytoplasmic staining of all types of carcinomas, gliomas and lymphomas.
Benign: cytoplasmic positivity in epithelia, stroma cells,endothelium, plasma cells and macrophages. Lipocytes positive in nuclei.
CAB008642
Strong membranous staining was found in squamous epithelia. Strong cytoplasmic and membranous staining was also focally found in many tissues. Stromal cells and a subset of lymphoid cells were also strongly stained in many cases. CNS, gastrointestinal tract and most lymphoid cells were mainly negative.
Malignant cells showed similar staining properties as normal cells. Many cells were either negative or strongly stained. Subcellular localization was mainly membranous and cytoplasmic. Staining pattern was often focal and distinct secreted positivity was also found in many cases. The majority of malignant cells were negative.
The Human Protein Atlas project is funded
