P01375 [Direct mapping]
Tumor necrosis factor Tumor necrosis factor, membrane form Intracellular domain 1 Intracellular domain 2 C-domain 1 C-domain 2 Tumor necrosis factor, soluble form
Q5STB3 [Target identity:100%; Query identity:100%]
C-domain 1

GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001774 [microglial cell activation]
GO:0001819 [positive regulation of cytokine production]
GO:0001891 [phagocytic cup]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002020 [protease binding]
GO:0002439 [chronic inflammatory response to antigenic stimulus]
GO:0002637 [regulation of immunoglobulin production]
GO:0002719 [negative regulation of cytokine production involved in immune response]
GO:0002876 [positive regulation of chronic inflammatory response to antigenic stimulus]
GO:0002925 [positive regulation of humoral immune response mediated by circulating immunoglobulin]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006006 [glucose metabolic process]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006959 [humoral immune response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0007275 [multicellular organism development]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009615 [response to virus]
GO:0009651 [response to salt stress]
GO:0009887 [animal organ morphogenesis]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0010573 [vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010693 [negative regulation of alkaline phosphatase activity]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010888 [negative regulation of lipid storage]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030198 [extracellular matrix organization]
GO:0030316 [osteoclast differentiation]
GO:0030730 [sequestering of triglyceride]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031622 [positive regulation of fever generation]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032722 [positive regulation of chemokine production]
GO:0032724 [positive regulation of fractalkine production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity]
GO:0042127 [regulation of cell population proliferation]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043068 [positive regulation of programmed cell death]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043242 [negative regulation of protein-containing complex disassembly]
GO:0043243 [positive regulation of protein-containing complex disassembly]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043491 [protein kinase B signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045071 [negative regulation of viral genome replication]
GO:0045121 [membrane raft]
GO:0045123 [cellular extravasation]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045598 [regulation of fat cell differentiation]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045785 [positive regulation of cell adhesion]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045994 [positive regulation of translational initiation by iron]
GO:0046325 [negative regulation of glucose import]
GO:0046330 [positive regulation of JNK cascade]
GO:0046427 [positive regulation of receptor signaling pathway via JAK-STAT]
GO:0048143 [astrocyte activation]
GO:0048566 [embryonic digestive tract development]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050708 [regulation of protein secretion]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0050766 [positive regulation of phagocytosis]
GO:0050768 [negative regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0050806 [positive regulation of synaptic transmission]
GO:0050807 [regulation of synapse organization]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050890 [cognition]
GO:0050900 [leukocyte migration]
GO:0050901 [leukocyte tethering or rolling]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051173 [positive regulation of nitrogen compound metabolic process]
GO:0051222 [positive regulation of protein transport]
GO:0051384 [response to glucocorticoid]
GO:0051798 [positive regulation of hair follicle development]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055037 [recycling endosome]
GO:0060252 [positive regulation of glial cell proliferation]
GO:0060557 [positive regulation of vitamin D biosynthetic process]
GO:0060559 [positive regulation of calcidiol 1-monooxygenase activity]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060693 [regulation of branching involved in salivary gland morphogenesis]
GO:0061044 [negative regulation of vascular wound healing]
GO:0061048 [negative regulation of branching involved in lung morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071316 [cellular response to nicotine]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071550 [death-inducing signaling complex assembly]
GO:0071677 [positive regulation of mononuclear cell migration]
GO:0071803 [positive regulation of podosome assembly]
GO:0072577 [endothelial cell apoptotic process]
GO:0072659 [protein localization to plasma membrane]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097527 [necroptotic signaling pathway]
GO:0150078 [positive regulation of neuroinflammatory response]
GO:0150129 [positive regulation of interleukin-33 production]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:1900222 [negative regulation of amyloid-beta clearance]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1901647 [positive regulation of synoviocyte proliferation]
GO:1901671 [positive regulation of superoxide dismutase activity]
GO:1902004 [positive regulation of amyloid-beta formation]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903140 [regulation of establishment of endothelial barrier]
GO:1903347 [negative regulation of bicellular tight junction assembly]
GO:1903721 [positive regulation of I-kappaB phosphorylation]
GO:1903799 [negative regulation of production of miRNAs involved in gene silencing by miRNA]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1904999 [positive regulation of leukocyte adhesion to arterial endothelial cell]
GO:2000010 [positive regulation of protein localization to cell surface]
GO:2000272 [negative regulation of signaling receptor activity]
GO:2000304 [positive regulation of ceramide biosynthetic process]
GO:2000334 [positive regulation of blood microparticle formation]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000351 [regulation of endothelial cell apoptotic process]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2001234 [negative regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]