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LYN
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  • LYN
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

LYN
Synonyms JTK8
Gene descriptioni

Full gene name according to HGNC.

LYN proto-oncogene, Src family tyrosine kinase
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 8
Cytoband q12.1
Chromosome location (bp) 55879835 - 56014169
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
Ensembl ENSG00000254087 (version 103.38)
Entrez gene 4067
HGNC HGNC:6735
UniProt P07948 (UniProt - Evidence at protein level)
neXtProt NX_P07948
Antibodypedia LYN antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 149

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
LYN-202
LYN-203
LYN-204


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
LYN-202
ENSP00000428924
ENST00000519728
P07948 [Direct mapping]
Tyrosine-protein kinase Lyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001782 [B cell homeostasis]
GO:0001817 [regulation of cytokine production]
GO:0001932 [regulation of protein phosphorylation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002431 [Fc receptor mediated stimulatory signaling pathway]
GO:0002513 [tolerance induction to self antigen]
GO:0002553 [histamine secretion by mast cell]
GO:0002576 [platelet degranulation]
GO:0002762 [negative regulation of myeloid leukocyte differentiation]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0002774 [Fc receptor mediated inhibitory signaling pathway]
GO:0002902 [regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005758 [mitochondrial intermembrane space]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006991 [response to sterol depletion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009636 [response to toxic substance]
GO:0009725 [response to hormone]
GO:0009743 [response to carbohydrate]
GO:0010976 [positive regulation of neuron projection development]
GO:0014003 [oligodendrocyte development]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014069 [postsynaptic density]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017124 [SH3 domain binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030061 [mitochondrial crista]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030218 [erythrocyte differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030889 [negative regulation of B cell proliferation]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031668 [cellular response to extracellular stimulus]
GO:0031966 [mitochondrial membrane]
GO:0032868 [response to insulin]
GO:0032991 [protein-containing complex]
GO:0033003 [regulation of mast cell activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034605 [cellular response to heat]
GO:0034666 [integrin alpha2-beta1 complex]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042493 [response to drug]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0043015 [gamma-tubulin binding]
GO:0043200 [response to amino acid]
GO:0043208 [glycosphingolipid binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043304 [regulation of mast cell degranulation]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043434 [response to peptide hormone]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044325 [ion channel binding]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045646 [regulation of erythrocyte differentiation]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048678 [response to axon injury]
GO:0050727 [regulation of inflammatory response]
GO:0050777 [negative regulation of immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0050855 [regulation of B cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051219 [phosphoprotein binding]
GO:0051272 [positive regulation of cellular component movement]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0060252 [positive regulation of glial cell proliferation]
GO:0060369 [positive regulation of Fc receptor mediated stimulatory signaling pathway]
GO:0060397 [growth hormone receptor signaling pathway via JAK-STAT]
GO:0070062 [extracellular exosome]
GO:0070304 [positive regulation of stress-activated protein kinase signaling cascade]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070447 [positive regulation of oligodendrocyte progenitor proliferation]
GO:0070667 [negative regulation of mast cell proliferation]
GO:0070668 [positive regulation of mast cell proliferation]
GO:0071300 [cellular response to retinoic acid]
GO:0090025 [regulation of monocyte chemotaxis]
GO:0090330 [regulation of platelet aggregation]
GO:0097028 [dendritic cell differentiation]
GO:0098978 [glutamatergic synapse]
GO:0099091 [postsynaptic specialization, intracellular component]
GO:0140031 [phosphorylation-dependent protein binding]
GO:1902532 [negative regulation of intracellular signal transduction]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:2000670 [positive regulation of dendritic cell apoptotic process]
Show all
512 aa
58.6 kDa
No 0
LYN-203
ENSP00000428313
ENST00000520050
E5RJ37 [Direct mapping]
Tyrosine-protein kinase Lyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
150 aa
17.1 kDa
No 0
LYN-204
ENSP00000428424
ENST00000520220
P07948 [Direct mapping]
Tyrosine-protein kinase Lyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001782 [B cell homeostasis]
GO:0001817 [regulation of cytokine production]
GO:0001932 [regulation of protein phosphorylation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002431 [Fc receptor mediated stimulatory signaling pathway]
GO:0002513 [tolerance induction to self antigen]
GO:0002576 [platelet degranulation]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0002774 [Fc receptor mediated inhibitory signaling pathway]
GO:0002902 [regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009725 [response to hormone]
GO:0010976 [positive regulation of neuron projection development]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030218 [erythrocyte differentiation]
GO:0030889 [negative regulation of B cell proliferation]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0033003 [regulation of mast cell activation]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043304 [regulation of mast cell degranulation]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045646 [regulation of erythrocyte differentiation]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050777 [negative regulation of immune response]
GO:0050855 [regulation of B cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051272 [positive regulation of cellular component movement]
GO:0060397 [growth hormone receptor signaling pathway via JAK-STAT]
GO:0070062 [extracellular exosome]
GO:0070304 [positive regulation of stress-activated protein kinase signaling cascade]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070667 [negative regulation of mast cell proliferation]
GO:0070668 [positive regulation of mast cell proliferation]
GO:0071300 [cellular response to retinoic acid]
GO:0090025 [regulation of monocyte chemotaxis]
GO:0090330 [regulation of platelet aggregation]
GO:0097028 [dendritic cell differentiation]
GO:0140031 [phosphorylation-dependent protein binding]
GO:1902532 [negative regulation of intracellular signal transduction]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:2000670 [positive regulation of dendritic cell apoptotic process]
Show all
491 aa
56 kDa
No 0

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  • PRESS ROOM
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  • PUBLICATIONS

The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.