We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Candidate cardiovascular disease genes Disease related genes Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.5
Chromosome location (bp)
2159779 - 2161221
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
INS-201
INS-202
INS-203
INS-204
INS-205
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P01308 [Direct mapping] Insulin Insulin B chain Insulin A chain I3WAC9 [Target identity:100%; Query identity:100%] Insulin
Show all
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0001819 [positive regulation of cytokine production] GO:0002020 [protease binding] GO:0002674 [negative regulation of acute inflammatory response] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007165 [signal transduction] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell population proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0010628 [positive regulation of gene expression] GO:0010750 [positive regulation of nitric oxide mediated signal transduction] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0022898 [regulation of transmembrane transporter activity] GO:0030133 [transport vesicle] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0031904 [endosome lumen] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032148 [activation of protein kinase B activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032880 [regulation of protein localization] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0033861 [negative regulation of NAD(P)H oxidase activity] GO:0034774 [secretory granule lumen] GO:0042060 [wound healing] GO:0042177 [negative regulation of protein catabolic process] GO:0042593 [glucose homeostasis] GO:0042802 [identical protein binding] GO:0043410 [positive regulation of MAPK cascade] GO:0044267 [cellular protein metabolic process] GO:0045597 [positive regulation of cell differentiation] GO:0045721 [negative regulation of gluconeogenesis] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045818 [negative regulation of glycogen catabolic process] GO:0045821 [positive regulation of glycolytic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045861 [negative regulation of proteolysis] GO:0045922 [negative regulation of fatty acid metabolic process] GO:0046326 [positive regulation of glucose import] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0046631 [alpha-beta T cell activation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048167 [regulation of synaptic plasticity] GO:0050708 [regulation of protein secretion] GO:0050709 [negative regulation of protein secretion] GO:0050890 [cognition] GO:0050995 [negative regulation of lipid catabolic process] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055089 [fatty acid homeostasis] GO:0060266 [negative regulation of respiratory burst involved in inflammatory response] GO:0060267 [positive regulation of respiratory burst] GO:0090277 [positive regulation of peptide hormone secretion] GO:0090336 [positive regulation of brown fat cell differentiation] GO:0097755 [positive regulation of blood vessel diameter] GO:0097756 [negative regulation of blood vessel diameter] GO:1900182 [positive regulation of protein localization to nucleus] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1902952 [positive regulation of dendritic spine maintenance] GO:1903076 [regulation of protein localization to plasma membrane] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1990535 [neuron projection maintenance] GO:2000252 [negative regulation of feeding behavior]
P01308 [Direct mapping] Insulin Insulin B chain Insulin A chain I3WAC9 [Target identity:100%; Query identity:100%] Insulin
Show all
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0001819 [positive regulation of cytokine production] GO:0002020 [protease binding] GO:0002674 [negative regulation of acute inflammatory response] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007165 [signal transduction] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell population proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0010628 [positive regulation of gene expression] GO:0010750 [positive regulation of nitric oxide mediated signal transduction] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0022898 [regulation of transmembrane transporter activity] GO:0030133 [transport vesicle] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0031904 [endosome lumen] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032148 [activation of protein kinase B activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032880 [regulation of protein localization] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0033861 [negative regulation of NAD(P)H oxidase activity] GO:0034774 [secretory granule lumen] GO:0042060 [wound healing] GO:0042177 [negative regulation of protein catabolic process] GO:0042593 [glucose homeostasis] GO:0042802 [identical protein binding] GO:0043410 [positive regulation of MAPK cascade] GO:0044267 [cellular protein metabolic process] GO:0045597 [positive regulation of cell differentiation] GO:0045721 [negative regulation of gluconeogenesis] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045818 [negative regulation of glycogen catabolic process] GO:0045821 [positive regulation of glycolytic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045861 [negative regulation of proteolysis] GO:0045922 [negative regulation of fatty acid metabolic process] GO:0046326 [positive regulation of glucose import] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0046631 [alpha-beta T cell activation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048167 [regulation of synaptic plasticity] GO:0050708 [regulation of protein secretion] GO:0050709 [negative regulation of protein secretion] GO:0050890 [cognition] GO:0050995 [negative regulation of lipid catabolic process] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055089 [fatty acid homeostasis] GO:0060266 [negative regulation of respiratory burst involved in inflammatory response] GO:0060267 [positive regulation of respiratory burst] GO:0090277 [positive regulation of peptide hormone secretion] GO:0090336 [positive regulation of brown fat cell differentiation] GO:0097755 [positive regulation of blood vessel diameter] GO:0097756 [negative regulation of blood vessel diameter] GO:1900182 [positive regulation of protein localization to nucleus] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1902952 [positive regulation of dendritic spine maintenance] GO:1903076 [regulation of protein localization to plasma membrane] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1990535 [neuron projection maintenance] GO:2000252 [negative regulation of feeding behavior]
P01308 [Direct mapping] Insulin Insulin B chain Insulin A chain I3WAC9 [Target identity:100%; Query identity:100%] Insulin
Show all
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0001819 [positive regulation of cytokine production] GO:0002020 [protease binding] GO:0002674 [negative regulation of acute inflammatory response] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007165 [signal transduction] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell population proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0010628 [positive regulation of gene expression] GO:0010750 [positive regulation of nitric oxide mediated signal transduction] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0022898 [regulation of transmembrane transporter activity] GO:0030133 [transport vesicle] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0031904 [endosome lumen] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032148 [activation of protein kinase B activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032880 [regulation of protein localization] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0033861 [negative regulation of NAD(P)H oxidase activity] GO:0034774 [secretory granule lumen] GO:0042060 [wound healing] GO:0042177 [negative regulation of protein catabolic process] GO:0042593 [glucose homeostasis] GO:0042802 [identical protein binding] GO:0043410 [positive regulation of MAPK cascade] GO:0044267 [cellular protein metabolic process] GO:0045597 [positive regulation of cell differentiation] GO:0045721 [negative regulation of gluconeogenesis] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045818 [negative regulation of glycogen catabolic process] GO:0045821 [positive regulation of glycolytic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045861 [negative regulation of proteolysis] GO:0045922 [negative regulation of fatty acid metabolic process] GO:0046326 [positive regulation of glucose import] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0046631 [alpha-beta T cell activation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048167 [regulation of synaptic plasticity] GO:0050708 [regulation of protein secretion] GO:0050709 [negative regulation of protein secretion] GO:0050890 [cognition] GO:0050995 [negative regulation of lipid catabolic process] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055089 [fatty acid homeostasis] GO:0060266 [negative regulation of respiratory burst involved in inflammatory response] GO:0060267 [positive regulation of respiratory burst] GO:0090277 [positive regulation of peptide hormone secretion] GO:0090336 [positive regulation of brown fat cell differentiation] GO:0097755 [positive regulation of blood vessel diameter] GO:0097756 [negative regulation of blood vessel diameter] GO:1900182 [positive regulation of protein localization to nucleus] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1902952 [positive regulation of dendritic spine maintenance] GO:1903076 [regulation of protein localization to plasma membrane] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1990535 [neuron projection maintenance] GO:2000252 [negative regulation of feeding behavior]
The Human Protein Atlas project is funded
