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MRPS21
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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:92.7 nTPM
HPA:92.7 nTPM
GTEx:76.3 nTPM
FANTOM5:66.7 Scaled Tags Per Million
Pig:61.7 nTPM
Mouse:177.2 nTPM
Allen mouse:2.6 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 92.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 87.6
1827 Male, age 72, unknown 92.6
2019 Male, age 18, unknown 91.1
2411 Female, age 72, unknown 89.4
1870 Female, age 42, unknown 88.3
1833 Male, age 53, unknown 88.1
2828 Female, age 72, unknown 87.0
2666 Male, age 74, left hemisphere 86.0
1830 Male, age 51, unknown 85.8
2219 Male, age 76, both hemispheres 85.8
2586 Male, age 75, left hemisphere 82.2
Dorsal raphe nucleus
nTPM: 89.0
1828 Male, age 53, unknown 91.6
2298 Female, age 72, unknown 90.4
2047 Male, age 72, unknown 88.9
2750 Male, age 76, both hemispheres 87.1
2016 Female, age 72, unknown 86.8
Inferior colliculus
nTPM: 89.8
1848 Female, age 42, unknown 90.6
2097 Female, age 72, unknown 90.3
2849 Male, age 72, unknown 90.0
1890 Male, age 53, unknown 88.4
Median raphe nucleus
nTPM: 90.2
2220 Male, age 76, midline 90.2
Pedunculopontine tegmental nucleus
nTPM: 90.4
2334 Male, age 80, both hemispheres 91.3
1921 Female, age 85, both hemispheres 91.2
2338 Male, age 61, both hemispheres 88.5
Periaquaductal grey, anterior
nTPM: 89.9
1947 Male, age 18, unknown 91.0
1795 Male, age 51, unknown 90.7
2502 Female, age 75, unknown 87.9
Periaquaductal grey, dorsal
nTPM: 88.6
2850 Male, age 76, both hemispheres 91.0
1840 Male, age 53, unknown 88.4
1831 Male, age 72, unknown 87.8
2464 Female, age 72, unknown 87.2
Periaquaductal grey, lateral
nTPM: 90.3
2272 Male, age 74, both hemispheres 94.1
2053 Male, age 18, unknown 88.8
2140 Male, age 76, both hemispheres 87.9
Pretectal area
nTPM: 92.7
1816 Male, age 51, unknown 97.7
1817 Female, age 42, unknown 97.6
2007 Male, age 72, unknown 96.6
1944 Female, age 72, unknown 94.9
2667 Female, age 75, unknown 94.0
1815 Male, age 53, unknown 92.7
2273 Male, age 74, both hemispheres 92.3
2224 Female, age 72, unknown 89.9
2407 Male, age 75, both hemispheres 88.7
2825 Male, age 18, unknown 88.4
2316 Male, age 76, right hemisphere 87.3
Red nucleus
nTPM: 88.0
1821 Female, age 72, unknown 91.0
2725 Female, age 75, unknown 90.9
2785 Male, age 18, unknown 90.4
2588 Male, age 74, left hemisphere 88.5
1954 Female, age 42, unknown 88.3
2503 Female, age 72, unknown 87.8
2584 Male, age 75, left hemisphere 87.5
2823 Male, age 76, right hemisphere 87.5
2769 Male, age 72, unknown 87.2
2227 Male, age 72, unknown 86.8
1865 Male, age 51, unknown 86.0
1904 Male, age 53, unknown 84.7
Substantia nigra
nTPM: 89.2
1889 Female, age 72, unknown 93.1
2409 Female, age 72, unknown 92.2
1941 Male, age 53, unknown 91.8
1916 Female, age 42, unknown 91.2
2665 Male, age 74, both hemispheres 89.8
1851 Male, age 51, unknown 89.0
2590 Female, age 75, unknown 87.8
2241 Male, age 72, unknown 87.3
2699 Male, age 18, unknown 85.9
2583 Male, age 75, right hemisphere 83.7
Superior colliculus
nTPM: 88.9
2087 Female, age 72, unknown 92.2
1895 Male, age 76, right hemisphere 91.2
2261 Male, age 18, unknown 90.2
2587 Male, age 74, left hemisphere 89.6
1839 Male, age 51, unknown 89.5
1796 Male, age 53, unknown 89.0
2664 Male, age 75, both hemispheres 88.4
2668 Female, age 75, unknown 87.9
1913 Female, age 42, unknown 86.0
1995 Male, age 72, unknown 85.3
Ventral tegmental area
nTPM: 87.6
2410 Female, age 72, unknown 89.1
2218 Male, age 76, both hemispheres 89.0
1915 Female, age 42, unknown 88.2
2021 Male, age 53, unknown 86.6
2223 Female, age 72, unknown 86.3
1942 Male, age 51, unknown 86.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 76.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 76.3
Samples: 139

Max nTPM: 122.9
Min nTPM: 45.6
Std nTPM: 15.8
Median nTPM: 74.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 122.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 122.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 116.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 115.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 110.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 110.2
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 107.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 106.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 106.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 102.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 102.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 101.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 99.4
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 97.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 97.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 97.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 96.6
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 93.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 93.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 93.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 92.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 91.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 91.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 90.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 90.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 90.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 89.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 89.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 89.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 88.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 86.5
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 85.7
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 85.2
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 85.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 84.7
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 84.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 83.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 83.7
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 83.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 83.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 83.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 82.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 82.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 82.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 82.0
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 81.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 81.5
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 81.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 81.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 81.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 80.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 79.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 79.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 79.1
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 78.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 77.7
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 77.5
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 77.5
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 77.4
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 77.4
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 76.4
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 76.3
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 75.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 75.7
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 75.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 75.4
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 74.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 74.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 74.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 74.5
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 74.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 74.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 73.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 73.9
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 73.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 72.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 72.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 71.9
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 71.9
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 71.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 71.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 71.6
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 71.4
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 70.7
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 70.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 70.4
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 70.0
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 69.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 69.7
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 69.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 69.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 68.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 68.6
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 68.4
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 67.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 66.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 66.3
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 66.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 65.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 65.4
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 64.7
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 64.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 64.5
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 64.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 64.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 64.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 63.7
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 63.2
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 62.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 62.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 62.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 61.6
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 61.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 61.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 60.7
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 60.6
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 60.5
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 60.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 60.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 59.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 59.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 58.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 58.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 57.9
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 57.8
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 57.7
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 57.1
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 56.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 56.6
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 55.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 55.2
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 55.2
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 54.1
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 54.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 53.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 52.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 51.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 47.9
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 45.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 66.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 66.7
FF:10158-103A5 76 years, female 66.7

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 61.7
Pig sample Sample description nTPM
Midbrain
nTPM: 58.7
Samples: 4

Max nTPM: 73.4
Min nTPM: 43.7
Sample A Female 73.4
Sample B Female 65.4
Sample C Male 52.2
Sample D Male 43.7
Periaqueductal gray
nTPM: 53.7
Samples: 3

Max nTPM: 54.8
Min nTPM: 51.7
Sample B Female 51.7
Sample C Male 54.5
Sample D Male 54.8
Substantia nigra
nTPM: 57.2
Samples: 4

Max nTPM: 76.5
Min nTPM: 43.7
Sample A Female 76.5
Sample B Female 50.6
Sample C Male 57.8
Sample D Male 43.7
Superior colliculi
nTPM: 61.7
Samples: 4

Max nTPM: 77.9
Min nTPM: 51.8
Sample A Female 77.9
Sample B Female 64.5
Sample C Male 51.8
Sample D Male 52.6

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 177.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 177.2
Samples: 4

Max nTPM: 187.1
Min nTPM: 168.8
Sample A Male 176.1
Sample B Male 168.8
Sample C Female 176.8
Sample D Female 187.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.6
68744803 Antisense, RP_050208_01_F09, Mouse strain C57BL/6J (56 days, male) 2.6

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