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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:515.0 nTPM
HPA:515.0 nTPM
GTEx:365.0 nTPM
FANTOM5:104.5 Scaled Tags Per Million
Pig:180.0 nTPM
Mouse:137.5 nTPM
Allen mouse:0.4 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 515.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 471.7
2586 Male, age 75, left hemisphere 537.6
2828 Female, age 72, unknown 523.6
1833 Male, age 53, unknown 471.1
1827 Male, age 72, unknown 466.7
1870 Female, age 42, unknown 464.6
2666 Male, age 74, left hemisphere 460.4
1830 Male, age 51, unknown 455.0
2411 Female, age 72, unknown 448.2
2019 Male, age 18, unknown 447.4
2219 Male, age 76, both hemispheres 442.6
Dorsal raphe nucleus
nTPM: 492.9
2016 Female, age 72, unknown 527.7
1828 Male, age 53, unknown 511.9
2298 Female, age 72, unknown 488.0
2047 Male, age 72, unknown 484.8
2750 Male, age 76, both hemispheres 451.9
Inferior colliculus
nTPM: 491.1
2849 Male, age 72, unknown 518.3
1848 Female, age 42, unknown 497.6
1890 Male, age 53, unknown 478.1
2097 Female, age 72, unknown 470.5
Median raphe nucleus
nTPM: 472.1
2220 Male, age 76, midline 472.1
Pedunculopontine tegmental nucleus
nTPM: 457.9
1921 Female, age 85, both hemispheres 480.7
2334 Male, age 80, both hemispheres 467.4
2338 Male, age 61, both hemispheres 425.4
Periaquaductal grey, anterior
nTPM: 478.0
2502 Female, age 75, unknown 489.3
1795 Male, age 51, unknown 482.6
1947 Male, age 18, unknown 462.0
Periaquaductal grey, dorsal
nTPM: 515.0
2850 Male, age 76, both hemispheres 556.8
1840 Male, age 53, unknown 531.9
1831 Male, age 72, unknown 488.9
2464 Female, age 72, unknown 482.6
Periaquaductal grey, lateral
nTPM: 503.4
2140 Male, age 76, both hemispheres 540.7
2053 Male, age 18, unknown 501.0
2272 Male, age 74, both hemispheres 468.5
Pretectal area
nTPM: 479.9
2825 Male, age 18, unknown 496.2
2273 Male, age 74, both hemispheres 494.4
2316 Male, age 76, right hemisphere 489.8
2667 Female, age 75, unknown 488.2
1944 Female, age 72, unknown 483.8
1817 Female, age 42, unknown 482.0
2224 Female, age 72, unknown 479.5
1816 Male, age 51, unknown 475.5
1815 Male, age 53, unknown 472.9
2407 Male, age 75, both hemispheres 472.2
2007 Male, age 72, unknown 443.9
Red nucleus
nTPM: 482.1
2769 Male, age 72, unknown 512.7
2227 Male, age 72, unknown 503.1
1821 Female, age 72, unknown 502.7
2503 Female, age 72, unknown 498.3
1954 Female, age 42, unknown 486.1
2588 Male, age 74, left hemisphere 478.7
2823 Male, age 76, right hemisphere 475.7
1904 Male, age 53, unknown 473.9
1865 Male, age 51, unknown 473.2
2725 Female, age 75, unknown 467.1
2584 Male, age 75, left hemisphere 460.6
2785 Male, age 18, unknown 453.7
Substantia nigra
nTPM: 495.7
2699 Male, age 18, unknown 592.2
1916 Female, age 42, unknown 522.1
1851 Male, age 51, unknown 517.9
2665 Male, age 74, both hemispheres 489.3
2590 Female, age 75, unknown 482.7
1889 Female, age 72, unknown 480.2
2583 Male, age 75, right hemisphere 476.2
2241 Male, age 72, unknown 469.2
2409 Female, age 72, unknown 465.9
1941 Male, age 53, unknown 461.8
Superior colliculus
nTPM: 486.1
2664 Male, age 75, both hemispheres 517.6
1995 Male, age 72, unknown 506.4
1796 Male, age 53, unknown 500.8
2668 Female, age 75, unknown 486.3
1913 Female, age 42, unknown 481.8
1839 Male, age 51, unknown 478.1
2087 Female, age 72, unknown 477.9
2261 Male, age 18, unknown 476.9
2587 Male, age 74, left hemisphere 469.7
1895 Male, age 76, right hemisphere 465.6
Ventral tegmental area
nTPM: 480.2
1915 Female, age 42, unknown 495.4
1942 Male, age 51, unknown 486.1
2021 Male, age 53, unknown 483.7
2410 Female, age 72, unknown 474.3
2218 Male, age 76, both hemispheres 472.9
2223 Female, age 72, unknown 468.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 365.0
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 365.0
Samples: 139

Max nTPM: 1057.1
Min nTPM: 37.6
Std nTPM: 181.7
Median nTPM: 337.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1057.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 861.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 775.2
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 748.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 735.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 734.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 704.6
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 687.6
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 687.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 675.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 671.3
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 670.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 669.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 668.4
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 658.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 643.3
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 629.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 618.7
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 599.0
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 568.9
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 562.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 553.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 528.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 519.8
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 498.0
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 496.3
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 494.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 490.0
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 486.3
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 478.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 472.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 472.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 470.3
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 462.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 458.5
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 450.2
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 441.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 440.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 437.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 437.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 437.3
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 430.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 425.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 424.4
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 424.0
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 418.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 417.3
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 401.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 397.3
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 393.6
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 393.6
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 390.4
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 385.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 377.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 377.1
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 376.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 376.3
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 372.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 365.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 358.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 358.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 357.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 356.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 355.3
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 351.1
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 348.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 344.8
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 341.9
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 338.3
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 337.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 336.8
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 336.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 332.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 331.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 325.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 324.0
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 322.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 321.1
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 319.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 316.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 312.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 312.5
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 308.9
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 303.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 303.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 299.4
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 297.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 296.5
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 294.4
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 288.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 284.6
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 281.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 278.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 276.6
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 275.9
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 262.6
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 262.1
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 260.0
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 256.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 249.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 246.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 245.9
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 244.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 237.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 231.7
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 223.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 218.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 217.0
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 213.3
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 211.4
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 211.4
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 211.2
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 207.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 205.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 195.4
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 193.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 191.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 188.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 182.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 180.6
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 178.7
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 176.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 174.4
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 166.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 164.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 145.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 145.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 134.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 122.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 121.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 114.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 112.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 104.5
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 102.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 99.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 97.5
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 94.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 62.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 37.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 104.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 104.5
FF:10158-103A5 76 years, female 104.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 180.0
Pig sample Sample description nTPM
Midbrain
nTPM: 177.0
Samples: 4

Max nTPM: 368.3
Min nTPM: 82.5
Sample A Female 368.3
Sample B Female 140.7
Sample C Male 116.3
Sample D Male 82.5
Periaqueductal gray
nTPM: 159.2
Samples: 3

Max nTPM: 174.5
Min nTPM: 149.7
Sample B Female 149.7
Sample C Male 174.5
Sample D Male 153.3
Substantia nigra
nTPM: 180.0
Samples: 4

Max nTPM: 205.5
Min nTPM: 146.3
Sample A Female 205.5
Sample B Female 183.9
Sample C Male 146.3
Sample D Male 184.4
Superior colliculi
nTPM: 177.6
Samples: 4

Max nTPM: 276.6
Min nTPM: 128.0
Sample A Female 175.4
Sample B Female 276.6
Sample C Male 128.0
Sample D Male 130.3

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 137.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 137.5
Samples: 4

Max nTPM: 160.0
Min nTPM: 117.0
Sample A Male 160.0
Sample B Male 117.0
Sample C Female 124.9
Sample D Female 148.2

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.4
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.4
68632918 Antisense, RP_050125_02_B01, Mouse strain C57BL/6J (56 days, male) 0.4

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