Cell line expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in. Read more	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function. Read more	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	Non-specific	Nucleosome assembly	75	Low
2	DU4475	Unknown function	236	Low
3	HUVEC & TIME	Signal transduction	475	Low
4	Non-specific	Transcription	402	Low
5	Non-specific	Unknown function	169	Very low
6	BEWO	Unknown function	232	Low
7	Neuronal cell lines	Stereocilium	210	Medium
8	Non-specific	Transcription	175	Low
9	Lymphoid cancers	Immune response	184	Medium
10	Ovarian & Endometrial cancers	Unknown function	395	Low
11	Lymphoma	Adaptive immune response	110	Low
12	Lymphoid cancers	Adaptive immune response	454	High
13	Non-specific	Nuclear processes	118	Low
14	Bone cancer	Transcription	164	Medium
15	Non-specific	Protein binding	270	Low
16	Skin cancer	Melanocyte processes	241	High
17	RS4;11	Unknown function	177	Medium
18	Non-specific	RNA binding	271	Very low
19	Stomach & Colon cancer	Absorption	612	Low
20	Connective tissue cells	ECM organization	611	High
21	Neuroblastoma	Neuronal signaling	390	High
22	Rhabdoid cancers	Neuronal signaling	291	Low
23	B-cell cancers	Adaptive immune response	505	High
24	Prostate cancer	Lipid metabolism	143	Low
25	Non-specific	Basic cellular processes	226	Low
26	NCI-H716	Unknown function	36	Low
27	TE 441.T	Unknown function	41	Low
28	Bone cancer CADO-ES1	Glutamate signalling	117	Low
29	TT & NCI-H1385	Synaptic signal transduction	239	High
30	Non-specific	Antiviral immune response	123	Medium
31	Non-specific	Transcription	223	Low
32	Myeloid leukemia	Oxygen transport	394	Low
33	Skin cancer	Membrane components	242	Medium
34	Rabdoid cancer	Embryonic development	276	Low
35	Liver cancer	Metabolism	220	Medium
36	Non-specific	Unknown function	160	Very low
37	Ovarian cancer RMG-I	Cellular stress response	431	Low
38	Non-specific	mRNA processing	308	Low
39	Non-specific	Unknown function	234	Very low
40	Non-specific	Enzymes	235	Very low
41	Non-specific	Cilium assembly	688	Very low
42	Sarcoma	Muscle contraction	184	Medium
43	Non-specific	Mitochondria	148	Low
44	Myeloma	Humoral immune response	768	High
45	Non-specific	Cell proliferation	1002	Low
46	Non-specific	Unknown function	459	Low
47	Retina	Visual perception	214	Low
48	Non-specific	RNA binding	219	Low
49	Non-specific	Unknown function	143	Low
50	L-1236 & L-428	Unknown function	105	Low
51	Myeloma	Humoral immune response	100	Low
52	Spermatids	Smell perception	218	Low
53	Non-specific	mRNA processing	239	Low
54	Lymphoma	Cytokine signaling	214	Medium
55	Non-specific	Unknown function	206	Low
56	Neurons	Neuronal signaling	102	Low
57	Non-specific	Translation	331	Medium
58	Non-specific	Basic cellular processes	294	Medium
59	Fibroblasts	Metabolism	192	Medium
60	Keratinocytes	Epithelial cell function	835	Medium
61	Liver	Metabolism	172	High
62	Granulocytes	Innate immune response	159	Medium
63	Non-specific	Unknown function	124	Low
64	Lymphoma	Humoral immune response	238	Medium
65	Breast cancer	Unknown function	581	Low
66	Myeloid cells	Innate immune response	444	Medium
67	Non-specific	Mitochondria & RNA binding	217	Low
68	Kidney	Mixed function	385	Medium
69	BICR 18	Unknown function	70	Low

The interactive UMAP plot displays the 69 gene clusters resulting from Louvain clustering of gene expression across all cell lines. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all cell lines for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.