Single cell type - FLT4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FLT4
Gene descriptionⁱ Full gene name according to HGNC.	Fms related receptor tyrosine kinase 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endothelial cells - Angiogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Extravillous trophoblasts, Endothelial cells, Adipocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type. Read more	0.89
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (MAIT T-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Extravillous trophoblasts, Endothelial cells, Adipocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Salivary gland Skeletal muscle Skin Small intestine Spleen Stomach Testis Thymus Tongue Vascular

EXPRESSION CLUSTERING & CORRELATIONⁱ

FLT4 is part of cluster 66 Endothelial cells - Angiogenesis with confidenceⁱ 1
468 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MMRN1	Multimerin 1	0.9282	66
CCL21	C-C motif chemokine ligand 21	0.9050	66
LRRC70	Leucine rich repeat containing 70	0.8415	66
ECSCR	Endothelial cell surface expressed chemotaxis and apoptosis regulator	0.8398	66
SHC1	SHC adaptor protein 1	0.8278	66
PKHD1L1	PKHD1 like 1	0.8183	66
GJD3	Gap junction protein delta 3	0.7996	66
RHOJ	Ras homolog family member J	0.7948	66
GJC2	Gap junction protein gamma 2	0.7865	66
BMX	BMX non-receptor tyrosine kinase	0.7728	66
ELK3	ETS transcription factor ELK3	0.7696	66
KANK3	KN motif and ankyrin repeat domains 3	0.7524	66
EFCC1	EF-hand and coiled-coil domain containing 1	0.7453	66
NR2F1	Nuclear receptor subfamily 2 group F member 1	0.7418	66
PLSCR4	Phospholipid scramblase 4	0.7347	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Salivary gland
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis
Cluster Expression Alphabetical Thymus
Cluster Expression Alphabetical Tongue
Cluster Expression Alphabetical Vascular

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

Alveolar cells type 1	0.3 nTPM
Lung	0.3 nTPM

Alveolar cells type 2	1.0 nTPM
Lung	1.0 nTPM

Astrocytes	0.6 nTPM
Brain	0.6 nTPM

B-cells	1.2 nTPM
Kidney	10.5 nTPM
Liver	4.9 nTPM
Thymus	0.6 nTPM
Salivary gland	0.2 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Basal keratinocytes	0.1 nTPM
Tongue	0.2 nTPM
Skin	0.0 nTPM

Club cells	0.4 nTPM
Lung	1.1 nTPM
Prostate	0.1 nTPM
Bronchus	0.0 nTPM

Endothelial cells	36.2 nTPM
Breast	146.9 nTPM
Liver	92.3 nTPM
Ovary	50.3 nTPM
Thymus	35.6 nTPM
Esophagus	33.4 nTPM
Skeletal muscle	30.1 nTPM
Placenta	29.3 nTPM
Salivary gland	26.0 nTPM
Skin	25.7 nTPM
Endometrium	23.6 nTPM
Lung	22.5 nTPM
Heart muscle	22.1 nTPM
Vascular	20.8 nTPM
Prostate	20.1 nTPM
Testis	17.6 nTPM
Tongue	11.0 nTPM
Pancreas	7.8 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	6.2 nTPM
Liver	92.6 nTPM
Stomach	2.9 nTPM
Thymus	0.6 nTPM
Esophagus	0.5 nTPM
Skin	0.3 nTPM
Lung	0.3 nTPM
Heart muscle	0.2 nTPM
Placenta	0.2 nTPM
Ovary	0.2 nTPM
Salivary gland	0.2 nTPM
Vascular	0.2 nTPM
Breast	0.2 nTPM
Skeletal muscle	0.1 nTPM
Pancreas	0.0 nTPM
Adipose tissue	0.0 nTPM
Prostate	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	0.5 nTPM
Esophagus	3.9 nTPM
Liver	3.4 nTPM
Thymus	1.5 nTPM
Skeletal muscle	0.6 nTPM
Vascular	0.4 nTPM
Breast	0.4 nTPM
Salivary gland	0.3 nTPM
Lung	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Ovary	0.0 nTPM
Prostate	0.0 nTPM
Tongue	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	0.3 nTPM
Liver	1.5 nTPM
Thymus	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM

Respiratory ciliated cells	0.1 nTPM
Lung	0.1 nTPM
Bronchus	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Extravillous trophoblasts	40.1 nTPM
Placenta	40.1 nTPM

Serous glandular cells	0.3 nTPM
Salivary gland	0.7 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.2 nTPM
Liver	26.7 nTPM
Skeletal muscle	4.8 nTPM
Heart muscle	2.0 nTPM
Esophagus	1.2 nTPM
Breast	1.0 nTPM
Adipose tissue	0.5 nTPM
Ovary	0.5 nTPM
Thymus	0.5 nTPM
Placenta	0.2 nTPM
Vascular	0.1 nTPM
Endometrium	0.0 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM

T-cells	1.7 nTPM
Thymus	13.7 nTPM
Salivary gland	4.2 nTPM
Lymph node	3.3 nTPM
Spleen	1.8 nTPM
Placenta	1.6 nTPM
Liver	1.3 nTPM
PBMC	1.3 nTPM
Adipose tissue	1.3 nTPM
Lung	1.3 nTPM
Skeletal muscle	1.1 nTPM
Kidney	0.9 nTPM
Vascular	0.8 nTPM
Skin	0.7 nTPM
Breast	0.7 nTPM
Endometrium	0.6 nTPM
Bone marrow	0.6 nTPM
Stomach	0.3 nTPM
Tongue	0.1 nTPM
Colon	0.0 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Rectum	0.1 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Salivary gland

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

Thymus

Tongue

Vascular

PBMC