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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:49.0 nTPM
HPA:49.0 nTPM
GTEx:48.7 nTPM
FANTOM5:30.3 Scaled Tags Per Million
Pig:21.7 nTPM
Mouse:72.6 nTPM
Allen mouse:0.8 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 49.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 47.5
2586 Male, age 75, left hemisphere 50.3
2219 Male, age 76, both hemispheres 48.5
2828 Female, age 72, unknown 48.2
2411 Female, age 72, unknown 48.1
1827 Male, age 72, unknown 47.7
1870 Female, age 42, unknown 47.6
1830 Male, age 51, unknown 46.9
1833 Male, age 53, unknown 46.4
2666 Male, age 74, left hemisphere 46.2
2019 Male, age 18, unknown 44.9
Dorsal raphe nucleus
nTPM: 46.4
1828 Male, age 53, unknown 47.6
2750 Male, age 76, both hemispheres 46.9
2016 Female, age 72, unknown 46.5
2047 Male, age 72, unknown 46.1
2298 Female, age 72, unknown 44.7
Inferior colliculus
nTPM: 47.2
2849 Male, age 72, unknown 47.8
1890 Male, age 53, unknown 47.4
1848 Female, age 42, unknown 47.0
2097 Female, age 72, unknown 46.6
Median raphe nucleus
nTPM: 48.5
2220 Male, age 76, midline 48.5
Pedunculopontine tegmental nucleus
nTPM: 47.4
2338 Male, age 61, both hemispheres 49.3
2334 Male, age 80, both hemispheres 47.7
1921 Female, age 85, both hemispheres 45.2
Periaquaductal grey, anterior
nTPM: 47.8
2502 Female, age 75, unknown 48.3
1947 Male, age 18, unknown 48.2
1795 Male, age 51, unknown 47.0
Periaquaductal grey, dorsal
nTPM: 45.7
1840 Male, age 53, unknown 46.5
2464 Female, age 72, unknown 45.9
1831 Male, age 72, unknown 45.5
2850 Male, age 76, both hemispheres 45.1
Periaquaductal grey, lateral
nTPM: 46.7
2272 Male, age 74, both hemispheres 47.2
2053 Male, age 18, unknown 46.8
2140 Male, age 76, both hemispheres 46.0
Pretectal area
nTPM: 46.5
2407 Male, age 75, both hemispheres 48.4
2667 Female, age 75, unknown 48.0
2273 Male, age 74, both hemispheres 47.2
2825 Male, age 18, unknown 47.1
2007 Male, age 72, unknown 46.9
1944 Female, age 72, unknown 46.7
1816 Male, age 51, unknown 46.3
1817 Female, age 42, unknown 46.0
2224 Female, age 72, unknown 46.0
2316 Male, age 76, right hemisphere 45.1
1815 Male, age 53, unknown 44.3
Red nucleus
nTPM: 48.3
2584 Male, age 75, left hemisphere 49.9
2227 Male, age 72, unknown 49.5
1865 Male, age 51, unknown 49.4
2588 Male, age 74, left hemisphere 49.1
2503 Female, age 72, unknown 48.9
2769 Male, age 72, unknown 48.3
1821 Female, age 72, unknown 48.1
1904 Male, age 53, unknown 47.7
2785 Male, age 18, unknown 47.5
2823 Male, age 76, right hemisphere 47.1
2725 Female, age 75, unknown 47.0
1954 Female, age 42, unknown 46.9
Substantia nigra
nTPM: 49.0
1916 Female, age 42, unknown 51.8
1851 Male, age 51, unknown 51.6
2699 Male, age 18, unknown 50.6
1941 Male, age 53, unknown 49.2
2583 Male, age 75, right hemisphere 49.0
2665 Male, age 74, both hemispheres 48.5
2241 Male, age 72, unknown 47.9
2409 Female, age 72, unknown 47.4
2590 Female, age 75, unknown 47.2
1889 Female, age 72, unknown 46.4
Superior colliculus
nTPM: 47.2
1796 Male, age 53, unknown 48.2
2668 Female, age 75, unknown 48.0
2261 Male, age 18, unknown 47.9
1913 Female, age 42, unknown 47.7
2664 Male, age 75, both hemispheres 47.4
2587 Male, age 74, left hemisphere 47.2
1895 Male, age 76, right hemisphere 46.7
1839 Male, age 51, unknown 46.3
2087 Female, age 72, unknown 46.3
1995 Male, age 72, unknown 46.1
Ventral tegmental area
nTPM: 48.1
1915 Female, age 42, unknown 50.8
2223 Female, age 72, unknown 48.7
2021 Male, age 53, unknown 48.4
2218 Male, age 76, both hemispheres 47.8
1942 Male, age 51, unknown 47.2
2410 Female, age 72, unknown 45.7

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 48.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 48.7
Samples: 139

Max nTPM: 113.0
Min nTPM: 22.3
Std nTPM: 12.9
Median nTPM: 46.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 113.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 106.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 89.7
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 78.0
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 74.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 71.9
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 68.8
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 66.3
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 64.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 63.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 63.5
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 63.1
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 63.0
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 62.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 62.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 62.0
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 60.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 60.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 60.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 60.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 60.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 59.2
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 59.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 58.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 58.0
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 58.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 57.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 56.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 56.5
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 56.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 55.9
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 55.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 55.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 55.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 55.2
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 55.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 54.9
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 54.8
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 54.3
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 54.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 53.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 53.5
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 53.0
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 52.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 52.2
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 51.8
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 51.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 51.3
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 50.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 50.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 50.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 50.5
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 50.0
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 49.9
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 49.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 49.3
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 48.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 48.9
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 48.8
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 48.5
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 48.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 48.3
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 48.0
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 47.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 47.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 47.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 47.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 46.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 46.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 46.6
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 46.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 46.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 46.5
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 46.2
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 46.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 45.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 45.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 45.7
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 45.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 45.6
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 45.3
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 45.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 45.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 44.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 44.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 44.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 43.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 43.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 43.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 43.7
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 43.5
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 43.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 43.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 43.0
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 42.9
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 42.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 42.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 42.0
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 41.9
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 41.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 41.6
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 41.1
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 40.9
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 40.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 40.7
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 40.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 40.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 40.2
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 40.2
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 39.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 39.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 39.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 39.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 38.8
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 38.6
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 38.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 38.5
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 37.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 37.8
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 37.6
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 37.3
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 37.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 37.1
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 37.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 36.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 35.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 33.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 33.3
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 32.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 32.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 31.5
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 31.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 31.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 29.7
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 29.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 27.7
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 27.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 26.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 22.3
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MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 30.3
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 30.3
FF:10158-103A5 76 years, female 30.3

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 21.7
Pig sample Sample description nTPM
Midbrain
nTPM: 21.7
Samples: 4

Max nTPM: 34.2
Min nTPM: 14.5
Sample A Female 34.2
Sample B Female 23.1
Sample C Male 14.5
Sample D Male 14.9
Periaqueductal gray
nTPM: 17.4
Samples: 3

Max nTPM: 19.0
Min nTPM: 14.6
Sample B Female 18.6
Sample C Male 19.0
Sample D Male 14.6
Substantia nigra
nTPM: 20.4
Samples: 4

Max nTPM: 27.9
Min nTPM: 16.7
Sample A Female 27.9
Sample B Female 16.7
Sample C Male 19.6
Sample D Male 17.5
Superior colliculi
nTPM: 19.1
Samples: 4

Max nTPM: 22.1
Min nTPM: 15.8
Sample A Female 22.1
Sample B Female 19.6
Sample C Male 18.7
Sample D Male 15.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 72.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 72.7
Samples: 4

Max nTPM: 80.6
Min nTPM: 63.6
Sample A Male 80.6
Sample B Male 68.0
Sample C Female 63.6
Sample D Female 78.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.8
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.8
68546242 Antisense, RP_050120_02_C02, Mouse strain C57BL/6J (56 days, male) 0.8

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