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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:169.2 nTPM
HPA:169.2 nTPM
GTEx:124.8 nTPM
FANTOM5:71.4 Scaled Tags Per Million
Pig:79.8 nTPM
Mouse:31.0 nTPM
Allen mouse:7.4 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 169.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 163.9
2219 Male, age 76, both hemispheres 180.1
2666 Male, age 74, left hemisphere 177.2
1827 Male, age 72, unknown 166.6
2586 Male, age 75, left hemisphere 164.6
2828 Female, age 72, unknown 164.4
2019 Male, age 18, unknown 161.2
1833 Male, age 53, unknown 158.9
1830 Male, age 51, unknown 157.9
1870 Female, age 42, unknown 156.2
2411 Female, age 72, unknown 152.0
Dorsal raphe nucleus
nTPM: 148.7
1828 Male, age 53, unknown 151.8
2016 Female, age 72, unknown 149.2
2298 Female, age 72, unknown 147.6
2750 Male, age 76, both hemispheres 147.5
2047 Male, age 72, unknown 147.3
Inferior colliculus
nTPM: 169.2
2097 Female, age 72, unknown 172.8
2849 Male, age 72, unknown 170.9
1848 Female, age 42, unknown 167.1
1890 Male, age 53, unknown 165.8
Median raphe nucleus
nTPM: 147.5
2220 Male, age 76, midline 147.5
Pedunculopontine tegmental nucleus
nTPM: 156.2
1921 Female, age 85, both hemispheres 157.4
2334 Male, age 80, both hemispheres 156.3
2338 Male, age 61, both hemispheres 154.9
Periaquaductal grey, anterior
nTPM: 160.9
2502 Female, age 75, unknown 163.8
1795 Male, age 51, unknown 162.0
1947 Male, age 18, unknown 156.9
Periaquaductal grey, dorsal
nTPM: 156.1
2464 Female, age 72, unknown 159.2
1831 Male, age 72, unknown 158.9
1840 Male, age 53, unknown 156.2
2850 Male, age 76, both hemispheres 150.1
Periaquaductal grey, lateral
nTPM: 153.3
2053 Male, age 18, unknown 157.9
2140 Male, age 76, both hemispheres 151.2
2272 Male, age 74, both hemispheres 150.7
Pretectal area
nTPM: 163.3
1816 Male, age 51, unknown 178.7
1817 Female, age 42, unknown 174.6
2007 Male, age 72, unknown 173.5
1944 Female, age 72, unknown 172.1
1815 Male, age 53, unknown 168.3
2316 Male, age 76, right hemisphere 160.8
2825 Male, age 18, unknown 156.6
2667 Female, age 75, unknown 156.1
2407 Male, age 75, both hemispheres 153.7
2224 Female, age 72, unknown 151.1
2273 Male, age 74, both hemispheres 150.6
Red nucleus
nTPM: 163.5
2588 Male, age 74, left hemisphere 176.5
2725 Female, age 75, unknown 173.6
2785 Male, age 18, unknown 166.9
2503 Female, age 72, unknown 166.0
2584 Male, age 75, left hemisphere 165.1
2227 Male, age 72, unknown 160.6
1954 Female, age 42, unknown 159.9
1865 Male, age 51, unknown 159.6
1904 Male, age 53, unknown 159.4
2823 Male, age 76, right hemisphere 158.9
2769 Male, age 72, unknown 158.8
1821 Female, age 72, unknown 156.8
Substantia nigra
nTPM: 159.1
2665 Male, age 74, both hemispheres 168.3
1889 Female, age 72, unknown 165.7
1851 Male, age 51, unknown 162.3
2699 Male, age 18, unknown 158.6
2409 Female, age 72, unknown 158.1
1941 Male, age 53, unknown 157.9
2583 Male, age 75, right hemisphere 156.9
2590 Female, age 75, unknown 156.9
1916 Female, age 42, unknown 155.0
2241 Male, age 72, unknown 151.5
Superior colliculus
nTPM: 164.9
1796 Male, age 53, unknown 174.2
2087 Female, age 72, unknown 169.6
2261 Male, age 18, unknown 166.6
1895 Male, age 76, right hemisphere 165.8
1995 Male, age 72, unknown 164.7
1913 Female, age 42, unknown 163.0
1839 Male, age 51, unknown 161.8
2664 Male, age 75, both hemispheres 161.4
2587 Male, age 74, left hemisphere 161.0
2668 Female, age 75, unknown 160.9
Ventral tegmental area
nTPM: 159.7
2223 Female, age 72, unknown 179.0
1915 Female, age 42, unknown 158.8
2410 Female, age 72, unknown 158.0
2218 Male, age 76, both hemispheres 157.2
1942 Male, age 51, unknown 152.9
2021 Male, age 53, unknown 152.1

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 124.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 124.8
Samples: 139

Max nTPM: 365.4
Min nTPM: 29.8
Std nTPM: 68.3
Median nTPM: 107.6
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 365.4
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 342.1
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 332.1
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 317.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 312.6
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 301.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 286.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 268.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 267.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 264.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 245.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 235.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 231.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 217.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 206.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 205.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 202.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 198.9
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 194.2
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 192.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 187.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 186.9
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 186.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 186.6
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 181.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 180.5
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 180.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 177.5
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 171.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 170.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 169.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 158.9
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 158.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 157.6
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 154.8
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 154.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 153.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 147.7
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 144.7
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 138.9
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 138.2
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 136.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 134.2
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 133.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 132.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 131.9
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 130.1
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 126.9
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 121.9
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 120.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 117.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 116.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 116.1
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 115.7
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 115.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 114.9
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 114.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 113.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 111.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 111.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 110.2
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 109.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 109.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 109.1
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 108.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 108.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 108.3
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 108.3
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 108.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 107.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 107.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 106.3
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 103.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 102.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 101.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 100.5
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 99.6
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 99.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 98.9
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 98.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 98.4
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 98.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 96.3
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 96.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 95.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 95.3
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 94.7
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 92.2
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 91.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 88.2
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 86.8
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 86.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 86.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 85.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 85.2
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 84.3
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 83.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 82.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 82.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 81.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 80.3
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 80.2
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 79.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 79.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 78.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 77.5
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 77.4
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 77.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 76.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 72.7
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 72.6
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 71.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 71.3
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 70.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 70.4
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 69.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 68.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 67.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 66.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 66.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 66.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 65.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 63.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 61.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 60.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 57.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 57.9
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 57.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 54.3
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 53.5
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 53.2
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 50.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 49.4
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 47.9
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 47.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 42.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 40.7
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 32.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 29.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 71.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 71.4
FF:10158-103A5 76 years, female 71.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 79.8
Pig sample Sample description nTPM
Midbrain
nTPM: 61.4
Samples: 4

Max nTPM: 85.4
Min nTPM: 30.0
Sample A Female 30.0
Sample B Female 46.9
Sample C Male 83.1
Sample D Male 85.4
Periaqueductal gray
nTPM: 29.0
Samples: 3

Max nTPM: 31.4
Min nTPM: 26.3
Sample B Female 29.2
Sample C Male 31.4
Sample D Male 26.3
Substantia nigra
nTPM: 54.8
Samples: 4

Max nTPM: 62.4
Min nTPM: 44.5
Sample A Female 59.3
Sample B Female 53.1
Sample C Male 62.4
Sample D Male 44.5
Superior colliculi
nTPM: 79.8
Samples: 4

Max nTPM: 92.3
Min nTPM: 59.2
Sample A Female 89.9
Sample B Female 59.2
Sample C Male 92.3
Sample D Male 77.7

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 31.0
Mouse sample Sample description nTPM
Midbrain
nTPM: 31.0
Samples: 4

Max nTPM: 33.8
Min nTPM: 27.8
Sample A Male 33.8
Sample B Male 27.8
Sample C Female 30.1
Sample D Female 32.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 7.4
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 7.4
68797501 Antisense, RP_050125_02_E12, Mouse strain C57BL/6J (56 days, male) 7.4

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