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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:52.7 nTPM
HPA:52.7 nTPM
GTEx:93.3 nTPM
FANTOM5:67.3 Scaled Tags Per Million
Pig:74.7 nTPM
Mouse:139.6 nTPM
Allen mouse:11.1 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 52.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 50.4
2586 Male, age 75, left hemisphere 99.1
2666 Male, age 74, left hemisphere 56.7
2828 Female, age 72, unknown 51.2
1827 Male, age 72, unknown 46.6
2219 Male, age 76, both hemispheres 45.9
2019 Male, age 18, unknown 43.6
1830 Male, age 51, unknown 41.2
1833 Male, age 53, unknown 41.2
1870 Female, age 42, unknown 40.8
2411 Female, age 72, unknown 37.2
Dorsal raphe nucleus
nTPM: 36.9
2750 Male, age 76, both hemispheres 47.3
2047 Male, age 72, unknown 46.9
1828 Male, age 53, unknown 35.4
2298 Female, age 72, unknown 29.7
2016 Female, age 72, unknown 25.5
Inferior colliculus
nTPM: 40.1
1848 Female, age 42, unknown 45.8
2849 Male, age 72, unknown 39.5
1890 Male, age 53, unknown 39.2
2097 Female, age 72, unknown 36.1
Median raphe nucleus
nTPM: 44.1
2220 Male, age 76, midline 44.1
Pedunculopontine tegmental nucleus
nTPM: 33.9
2334 Male, age 80, both hemispheres 42.3
1921 Female, age 85, both hemispheres 37.1
2338 Male, age 61, both hemispheres 22.2
Periaquaductal grey, anterior
nTPM: 46.0
1947 Male, age 18, unknown 50.0
1795 Male, age 51, unknown 46.6
2502 Female, age 75, unknown 41.3
Periaquaductal grey, dorsal
nTPM: 26.0
1840 Male, age 53, unknown 35.8
2464 Female, age 72, unknown 29.2
1831 Male, age 72, unknown 25.9
2850 Male, age 76, both hemispheres 13.1
Periaquaductal grey, lateral
nTPM: 22.2
2053 Male, age 18, unknown 32.6
2272 Male, age 74, both hemispheres 20.9
2140 Male, age 76, both hemispheres 13.0
Pretectal area
nTPM: 42.1
2007 Male, age 72, unknown 62.1
1944 Female, age 72, unknown 57.9
1817 Female, age 42, unknown 57.4
1816 Male, age 51, unknown 55.6
1815 Male, age 53, unknown 51.0
2825 Male, age 18, unknown 39.3
2667 Female, age 75, unknown 38.9
2407 Male, age 75, both hemispheres 38.1
2224 Female, age 72, unknown 28.0
2316 Male, age 76, right hemisphere 18.9
2273 Male, age 74, both hemispheres 16.5
Red nucleus
nTPM: 46.7
2588 Male, age 74, left hemisphere 73.3
2584 Male, age 75, left hemisphere 60.1
2785 Male, age 18, unknown 47.6
2227 Male, age 72, unknown 44.6
2769 Male, age 72, unknown 44.6
1821 Female, age 72, unknown 43.7
1865 Male, age 51, unknown 43.4
1904 Male, age 53, unknown 43.2
2503 Female, age 72, unknown 42.7
1954 Female, age 42, unknown 42.0
2823 Male, age 76, right hemisphere 39.9
2725 Female, age 75, unknown 34.9
Substantia nigra
nTPM: 52.7
2665 Male, age 74, both hemispheres 72.2
1916 Female, age 42, unknown 64.6
2583 Male, age 75, right hemisphere 60.9
1889 Female, age 72, unknown 56.4
1941 Male, age 53, unknown 54.7
1851 Male, age 51, unknown 54.5
2590 Female, age 75, unknown 45.0
2241 Male, age 72, unknown 43.0
2699 Male, age 18, unknown 39.2
2409 Female, age 72, unknown 36.8
Superior colliculus
nTPM: 45.2
2668 Female, age 75, unknown 73.5
2664 Male, age 75, both hemispheres 58.1
2587 Male, age 74, left hemisphere 48.8
1796 Male, age 53, unknown 47.6
2087 Female, age 72, unknown 46.2
2261 Male, age 18, unknown 42.3
1839 Male, age 51, unknown 40.7
1895 Male, age 76, right hemisphere 36.4
1913 Female, age 42, unknown 30.0
1995 Male, age 72, unknown 28.3
Ventral tegmental area
nTPM: 46.7
2223 Female, age 72, unknown 61.6
2218 Male, age 76, both hemispheres 52.5
2410 Female, age 72, unknown 51.9
1915 Female, age 42, unknown 42.2
1942 Male, age 51, unknown 42.0
2021 Male, age 53, unknown 30.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 93.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 93.3
Samples: 139

Max nTPM: 181.4
Min nTPM: 38.8
Std nTPM: 30.4
Median nTPM: 88.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 181.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 174.5
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 158.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 156.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 156.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 155.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 152.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 152.3
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 148.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 146.3
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 145.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 145.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 144.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 144.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 137.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 136.6
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 135.8
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 134.2
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 130.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 129.0
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 128.2
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 122.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 122.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 121.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 120.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 119.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 119.0
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 117.4
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 116.6
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 115.9
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 113.9
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 113.4
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 112.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 112.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 112.0
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 110.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 109.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 109.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 108.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 108.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 107.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 106.3
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 106.0
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 105.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 104.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 104.7
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 104.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 103.0
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 103.0
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 101.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 101.0
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 99.9
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 98.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 98.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 96.6
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 95.2
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 95.2
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 94.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 94.7
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 94.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 92.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 92.4
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 92.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 92.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 91.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 90.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 89.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 89.2
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 88.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 88.9
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 88.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 88.2
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 87.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 87.0
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 86.2
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 85.9
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 85.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 84.5
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 84.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 84.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 83.9
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 83.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 81.8
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 81.7
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 81.5
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 81.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 80.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 80.4
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 80.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 79.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 78.8
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 78.6
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 78.4
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 77.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 76.6
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 76.6
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 76.4
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 76.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 75.0
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 74.7
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 74.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 73.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 73.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 71.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 70.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 69.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 69.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 69.1
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 68.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 68.0
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 67.8
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 67.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 67.1
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 63.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 63.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 63.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 62.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 62.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 60.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 60.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 59.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 58.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 57.0
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 56.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 56.4
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 54.0
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 52.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 51.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 51.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 50.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 50.4
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 50.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 49.2
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 49.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 48.4
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 48.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 45.6
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 43.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 38.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 67.3
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 67.3
FF:10158-103A5 76 years, female 67.3

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 74.7
Pig sample Sample description nTPM
Midbrain
nTPM: 74.7
Samples: 4

Max nTPM: 101.3
Min nTPM: 50.1
Sample A Female 80.8
Sample B Female 50.1
Sample C Male 101.3
Sample D Male 66.5
Periaqueductal gray
nTPM: 43.4
Samples: 3

Max nTPM: 47.4
Min nTPM: 38.8
Sample B Female 47.4
Sample C Male 44.1
Sample D Male 38.8
Substantia nigra
nTPM: 54.5
Samples: 4

Max nTPM: 63.2
Min nTPM: 35.6
Sample A Female 63.2
Sample B Female 35.6
Sample C Male 60.9
Sample D Male 58.4
Superior colliculi
nTPM: 69.1
Samples: 4

Max nTPM: 96.9
Min nTPM: 33.9
Sample A Female 66.0
Sample B Female 33.9
Sample C Male 96.9
Sample D Male 79.4

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 139.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 139.6
Samples: 4

Max nTPM: 145.1
Min nTPM: 133.0
Sample A Male 135.5
Sample B Male 133.0
Sample C Female 144.7
Sample D Female 145.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 11.1
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 11.1
74882698 Antisense, RP_060315_04_G04, Mouse strain C57BL/6J (56 days, male) 11.9
69817240 Antisense, RP_050510_02_H09, Mouse strain C57BL/6J (56 days, male) 10.3

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