Expression of ACTB in glioma - The Human Protein Atlas

GLIOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

ACTB is not prognostic in glioma

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 2160.4

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

3-year survival highⁱ N/A

3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

2162.3

Number of samples

153

Samples

Sample	Description	FPKM
TCGA-19-2625-01A	76 years, female, white, dead, 124 days	4016.8
TCGA-28-2513-01A	69 years, female, white, alive, 222 days	3264.3
TCGA-06-0190-01A	62 years, male, white, dead, 317 days	3189.9
TCGA-06-0210-01A	72 years, female, white, dead, 225 days	3185.1
TCGA-06-0184-01A	63 years, male, white, dead, 2126 days	3164.0
TCGA-06-0644-01A	71 years, male, black or african american, dead, 384 days	3138.7
TCGA-14-0781-01B	49 years, male, black or african american, dead, 29 days	3065.5
TCGA-26-5135-01A	72 years, female, white, dead, 270 days	3049.3
TCGA-06-0686-01A	53 years, male, white, dead, 432 days	3026.4
TCGA-06-0130-01A	54 years, male, white, dead, 394 days	3023.1
TCGA-02-2486-01A	64 years, male, white, dead, 618 days	3023.0
TCGA-12-0619-01A	60 years, male, white, dead, 1062 days	3020.1
TCGA-06-0745-01A	59 years, male, white, dead, 239 days	2944.9
TCGA-02-0055-01A	62 years, female, white, dead, 76 days	2937.6
TCGA-06-0174-01A	54 years, male, white, dead, 98 days	2935.9
TCGA-41-2572-01A	67 years, male, white, dead, 406 days	2933.8
TCGA-06-0645-01A	56 years, female, white, dead, 175 days	2911.2
TCGA-28-5216-01A	52 years, male, white, alive, 415 days	2910.3
TCGA-32-2616-01A	48 years, female, white, dead, 224 days	2867.9
TCGA-06-5418-01A	75 years, female, white, dead, 83 days	2828.1
TCGA-28-2509-01A	77 years, female, white, alive, 145 days	2827.6
TCGA-27-2523-01A	63 years, male, white, dead, 489 days	2810.7
TCGA-06-0646-01A	61 years, male, white, dead, 175 days	2773.1
TCGA-06-2562-01A	81 years, male, white, dead, 382 days	2761.0
TCGA-06-5412-01A	78 years, female, white, dead, 138 days	2709.9
TCGA-14-1034-01A	60 years, female, dead, 485 days	2659.0
TCGA-27-2524-01A	56 years, male, white, dead, 231 days	2658.3
TCGA-27-2519-01A	48 years, male, white, dead, 550 days	2656.8
TCGA-32-4213-01A	47 years, female, white, alive, 604 days	2638.3
TCGA-19-2619-01A	55 years, female, black or african american, alive, 294 days	2629.2
TCGA-14-2554-01A	52 years, female, white, dead, 532 days	2617.2
TCGA-76-4928-01B	85 years, female, white, dead, 94 days	2575.5
TCGA-06-0211-01B	47 years, male, white, dead, 360 days	2569.4
TCGA-14-0789-01A	54 years, male, white, dead, 342 days	2566.0
TCGA-06-5410-01A	72 years, female, white, dead, 108 days	2539.3
TCGA-06-2564-01A	50 years, male, white, alive, 181 days	2534.8
TCGA-06-0168-01A	59 years, female, white, dead, 598 days	2529.7
TCGA-41-2571-01A	89 years, male, white, dead, 26 days	2504.1
TCGA-19-1390-01A	63 years, female, white, dead, 772 days	2492.7
TCGA-28-5218-01A	63 years, male, white, dead, 157 days	2492.1
TCGA-06-0238-01A	46 years, male, white, dead, 405 days	2477.1
TCGA-19-2629-01A	60 years, male, white, dead, 737 days	2466.1
TCGA-27-1830-01A	57 years, male, white, dead, 154 days	2458.6
TCGA-06-5414-01A	61 years, male, white, alive, 273 days	2452.9
TCGA-14-1825-01A	70 years, male, white, dead, 232 days	2446.3
TCGA-19-1787-01B	49 years, male, white, dead, 385 days	2439.1
TCGA-12-0618-01A	49 years, male, white, dead, 395 days	2420.4
TCGA-28-5209-01A	66 years, female, white, alive, 77 days	2399.2
TCGA-12-5299-01A	56 years, female, white, dead, 98 days	2371.7
TCGA-06-0125-01A	63 years, female, white, dead, 1448 days	2370.2
TCGA-28-1753-01A	53 years, male, white, alive, 37 days	2358.8
TCGA-12-5295-01A	60 years, female, white, dead, 454 days	2356.8
TCGA-06-0750-01A	43 years, male, white, dead, 28 days	2356.7
TCGA-06-0139-01A	40 years, male, white, dead, 362 days	2329.2
TCGA-14-0817-01A	69 years, female, white, dead, 164 days	2327.0
TCGA-26-5139-01A	65 years, female, white, alive, 48 days	2314.6
TCGA-32-2638-01A	67 years, male, white, dead, 766 days	2302.3
TCGA-27-2528-01A	62 years, male, white, dead, 480 days	2302.2
TCGA-06-0878-01A	74 years, male, white, alive, 218 days	2300.0
TCGA-76-4927-01A	58 years, male, white, dead, 535 days	2295.7
TCGA-06-0132-01A	49 years, male, white, dead, 771 days	2288.9
TCGA-41-3915-01A	48 years, male, white, dead, 360 days	2288.3
TCGA-76-4925-01A	76 years, male, white, dead, 146 days	2250.5
TCGA-32-5222-01A	66 years, male, white, dead, 585 days	2244.2
TCGA-32-1982-01A	76 years, female, white, dead, 142 days	2232.5
TCGA-06-2557-01A	76 years, male, black or african american, dead, 33 days	2227.7
TCGA-06-5858-01A	45 years, female, white, alive, 187 days	2226.3
TCGA-19-2624-01A	51 years, male, white, dead, 5 days	2222.2
TCGA-06-0187-01A	69 years, male, white, dead, 828 days	2202.4
TCGA-26-5134-01A	74 years, male, white, alive, 167 days	2190.5
TCGA-12-0616-01A	36 years, female, white, dead, 448 days	2186.6
TCGA-14-0787-01A	69 years, male, asian, dead, 68 days	2184.6
TCGA-12-3650-01A	46 years, male, white, dead, 333 days	2182.1
TCGA-06-2559-01A	83 years, male, white, dead, 150 days	2180.6
TCGA-08-0386-01A	74 years, male, white, dead, 548 days	2163.1
TCGA-06-0157-01A	63 years, female, white, dead, 97 days	2161.6
TCGA-28-5215-01A	62 years, female, white, dead, 335 days	2160.4
TCGA-27-1831-01A	66 years, male, white, dead, 505 days	2160.4
TCGA-76-4932-01A	50 years, female, white, dead, 1458 days	2155.0
TCGA-19-2620-01A	70 years, male, white, dead, 148 days	2139.9
TCGA-06-0882-01A	30 years, male, white, dead, 632 days	2109.2
TCGA-15-0742-01A	65 years, male, white, dead, 419 days	2105.1
TCGA-14-1823-01A	58 years, female, white, dead, 543 days	2091.5
TCGA-19-4065-01A	36 years, male, white, alive, 214 days	2072.0
TCGA-28-1747-01C	44 years, male, white, dead, 77 days	2059.8
TCGA-27-1834-01A	56 years, male, white, dead, 1233 days	2038.4
TCGA-28-5204-01A	72 years, male, white, dead, 454 days	2011.5
TCGA-02-2483-01A	43 years, male, asian, alive, 466 days	2009.4
TCGA-26-5132-01A	74 years, male, white, alive, 286 days	2003.5
TCGA-27-1837-01A	36 years, male, white, dead, 427 days	1983.5
TCGA-06-0158-01A	73 years, male, white, dead, 329 days	1977.7
TCGA-26-5133-01A	59 years, male, white, alive, 452 days	1973.2
TCGA-32-2615-01A	62 years, male, white, dead, 485 days	1961.0
TCGA-28-2514-01A	45 years, male, asian, alive, 160 days	1960.2
TCGA-06-0747-01A	53 years, male, white, dead, 82 days	1958.0
TCGA-16-1045-01B	49 years, female, white, dead, 883 days	1950.8
TCGA-06-0138-01A	43 years, male, white, dead, 737 days	1948.4
TCGA-02-0047-01A	78 years, male, white, dead, 448 days	1935.3
TCGA-27-2526-01A	79 years, female, white, dead, 87 days	1934.8
TCGA-16-0846-01A	85 years, male, white, dead, 119 days	1933.8
TCGA-28-5213-01A	72 years, male, white, alive, 951 days	1930.3
TCGA-06-2570-01A	21 years, female, white, alive, 958 days	1928.5
TCGA-12-0821-01A	62 years, male, white, dead, 323 days	1926.8
TCGA-32-2632-01A	80 years, male, white, dead, 269 days	1921.2
TCGA-06-2563-01A	72 years, female, white, alive, 932 days	1920.2
TCGA-26-1442-01A	43 years, male, white, alive, 953 days	1903.2
TCGA-26-5136-01B	78 years, female, white, dead, 577 days	1892.6
TCGA-41-4097-01A	63 years, female, white, dead, 6 days	1878.9
TCGA-06-0219-01A	67 years, male, white, dead, 22 days	1871.1
TCGA-06-0743-01A	69 years, male, white, dead, 803 days	1862.0
TCGA-76-4926-01B	68 years, male, white, dead, 138 days	1839.1
TCGA-06-5413-01A	67 years, male, white, alive, 268 days	1833.0
TCGA-14-0871-01A	75 years, female, white, dead, 880 days	1830.4
TCGA-02-2485-01A	53 years, male, black or african american, alive, 470 days	1819.5
TCGA-06-2558-01A	75 years, female, white, dead, 380 days	1816.5
TCGA-76-4931-01A	70 years, female, white, dead, 279 days	1805.6
TCGA-06-0141-01A	62 years, male, white, dead, 313 days	1780.2
TCGA-12-1597-01B	62 years, female, white, dead, 675 days	1777.2
TCGA-06-5411-01A	51 years, male, white, dead, 254 days	1769.8
TCGA-06-5408-01A	54 years, female, white, dead, 357 days	1763.4
TCGA-06-2561-01A	53 years, female, white, dead, 537 days	1762.7
TCGA-32-2634-01A	82 years, male, white, alive, 693 days	1734.1
TCGA-06-5856-01A	58 years, male, white, dead, 114 days	1729.0
TCGA-12-3653-01A	34 years, female, white, dead, 442 days	1709.1
TCGA-06-0749-01A	50 years, male, black or african american, dead, 82 days	1691.5
TCGA-06-0156-01A	57 years, male, white, dead, 178 days	1675.5
TCGA-14-1829-01A	57 years, male, black or african american, alive, 218 days	1652.4
TCGA-15-1444-01A	21 years, male, white, dead, 1537 days	1649.8
TCGA-06-5416-01A	23 years, female, white, alive, 204 days	1643.1
TCGA-06-0178-01A	39 years, male, white, dead, 2681 days	1606.8
TCGA-27-1832-01A	59 years, female, white, dead, 300 days	1605.6
TCGA-32-1970-01A	59 years, male, white, dead, 468 days	1600.8
TCGA-28-5208-01A	52 years, male, white, dead, 544 days	1579.7
TCGA-14-0790-01B	64 years, female, white, dead, 419 days	1562.2
TCGA-28-2499-01A	59 years, male, white, dead, 95 days	1543.3
TCGA-27-2521-01A	34 years, male, white, dead, 510 days	1538.5
TCGA-06-2567-01A	65 years, male, white, dead, 133 days	1533.4
TCGA-41-5651-01A	59 years, female, black or african american, dead, 460 days	1519.1
TCGA-32-1980-01A	72 years, male, white, dead, 36 days	1519.0
TCGA-06-0744-01A	67 years, male, white, dead, 1426 days	1509.6
TCGA-06-0649-01B	73 years, female, black or african american, dead, 64 days	1486.7
TCGA-12-3652-01A	60 years, male, white, dead, 1062 days	1462.1
TCGA-27-1835-01A	53 years, female, white, dead, 648 days	1419.1
TCGA-28-5207-01A	71 years, male, white, dead, 343 days	1341.9
TCGA-76-4929-01A	76 years, female, white, dead, 111 days	1341.3
TCGA-06-0129-01A	30 years, male, asian, dead, 1024 days	1340.5
TCGA-06-2565-01A	59 years, male, asian, dead, 506 days	1333.9
TCGA-06-5859-01A	63 years, male, white, alive, 139 days	1314.6
TCGA-28-5220-01A	67 years, male, white, dead, 388 days	1194.5
TCGA-06-5417-01A	45 years, female, white, alive, 155 days	1060.6
TCGA-06-1804-01A	81 years, female, white, dead, 414 days	1034.5
TCGA-19-5960-01A	56 years, male, white, dead, 455 days	861.2
TCGA-06-2569-01A	24 years, female, black or african american, alive, 13 days	628.9
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GLIOMA - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample. Read more	Antibody HPA041264	Antibody HPA041271	Antibody CAB002621
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details