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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
PRIMARY MOUSE DATA
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:510.1 nTPM
HPA:510.1 nTPM
GTEx:178.8 nTPM
FANTOM5:595.9 Scaled Tags Per Million
Pig:466.6 nTPM
Mouse:163.3 nTPM
Allen mouse:0.9 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 510.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 438.8
2828 Female, age 72, unknown 469.2
1827 Male, age 72, unknown 456.8
1870 Female, age 42, unknown 456.3
1833 Male, age 53, unknown 445.1
2219 Male, age 76, both hemispheres 441.1
2411 Female, age 72, unknown 435.8
2586 Male, age 75, left hemisphere 434.2
1830 Male, age 51, unknown 422.4
2019 Male, age 18, unknown 420.3
2666 Male, age 74, left hemisphere 407.0
Dorsal raphe nucleus
nTPM: 491.6
2298 Female, age 72, unknown 520.8
2016 Female, age 72, unknown 514.2
1828 Male, age 53, unknown 496.6
2047 Male, age 72, unknown 483.9
2750 Male, age 76, both hemispheres 442.3
Inferior colliculus
nTPM: 478.6
1848 Female, age 42, unknown 497.9
2849 Male, age 72, unknown 493.1
2097 Female, age 72, unknown 464.5
1890 Male, age 53, unknown 458.9
Median raphe nucleus
nTPM: 450.6
2220 Male, age 76, midline 450.6
Pedunculopontine tegmental nucleus
nTPM: 444.9
1921 Female, age 85, both hemispheres 466.2
2334 Male, age 80, both hemispheres 435.7
2338 Male, age 61, both hemispheres 432.9
Periaquaductal grey, anterior
nTPM: 472.7
1795 Male, age 51, unknown 489.3
2502 Female, age 75, unknown 465.1
1947 Male, age 18, unknown 463.8
Periaquaductal grey, dorsal
nTPM: 510.1
1840 Male, age 53, unknown 572.8
2850 Male, age 76, both hemispheres 529.1
2464 Female, age 72, unknown 481.9
1831 Male, age 72, unknown 456.5
Periaquaductal grey, lateral
nTPM: 496.9
2140 Male, age 76, both hemispheres 510.8
2053 Male, age 18, unknown 502.4
2272 Male, age 74, both hemispheres 477.4
Pretectal area
nTPM: 479.2
2273 Male, age 74, both hemispheres 543.7
1816 Male, age 51, unknown 512.6
1944 Female, age 72, unknown 503.4
2224 Female, age 72, unknown 494.4
2667 Female, age 75, unknown 492.7
1817 Female, age 42, unknown 474.1
2825 Male, age 18, unknown 466.8
2316 Male, age 76, right hemisphere 464.9
1815 Male, age 53, unknown 454.0
2407 Male, age 75, both hemispheres 435.1
2007 Male, age 72, unknown 429.1
Red nucleus
nTPM: 439.8
1954 Female, age 42, unknown 463.5
1821 Female, age 72, unknown 456.1
2503 Female, age 72, unknown 455.9
2725 Female, age 75, unknown 449.8
1904 Male, age 53, unknown 448.8
2823 Male, age 76, right hemisphere 448.4
2227 Male, age 72, unknown 447.2
2769 Male, age 72, unknown 447.1
1865 Male, age 51, unknown 431.5
2588 Male, age 74, left hemisphere 421.6
2785 Male, age 18, unknown 412.7
2584 Male, age 75, left hemisphere 394.7
Substantia nigra
nTPM: 476.7
2699 Male, age 18, unknown 547.0
1916 Female, age 42, unknown 518.1
2409 Female, age 72, unknown 488.6
2241 Male, age 72, unknown 487.4
1889 Female, age 72, unknown 479.3
1851 Male, age 51, unknown 468.7
2590 Female, age 75, unknown 467.0
2665 Male, age 74, both hemispheres 454.5
2583 Male, age 75, right hemisphere 428.4
1941 Male, age 53, unknown 427.7
Superior colliculus
nTPM: 465.3
2261 Male, age 18, unknown 489.2
2087 Female, age 72, unknown 488.6
1796 Male, age 53, unknown 482.9
1995 Male, age 72, unknown 481.4
1913 Female, age 42, unknown 462.3
2587 Male, age 74, left hemisphere 461.0
1839 Male, age 51, unknown 460.6
1895 Male, age 76, right hemisphere 445.4
2668 Female, age 75, unknown 443.9
2664 Male, age 75, both hemispheres 438.2
Ventral tegmental area
nTPM: 463.9
1915 Female, age 42, unknown 486.7
2410 Female, age 72, unknown 480.3
2021 Male, age 53, unknown 460.9
2218 Male, age 76, both hemispheres 458.7
1942 Male, age 51, unknown 453.1
2223 Female, age 72, unknown 443.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 178.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 178.8
Samples: 139

Max nTPM: 834.3
Min nTPM: 14.8
Std nTPM: 126.0
Median nTPM: 148.8
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 834.3
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 797.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 699.7
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 579.6
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 417.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 408.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 391.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 381.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 350.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 337.3
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 336.0
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 329.1
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 325.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 324.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 316.2
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 315.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 304.2
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 293.2
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 277.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 265.8
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 261.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 255.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 250.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 247.3
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 244.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 241.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 238.2
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 236.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 233.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 226.5
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 225.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 223.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 216.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 214.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 210.6
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 207.2
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 205.8
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 205.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 200.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 198.9
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 198.9
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 192.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 188.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 186.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 183.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 182.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 179.5
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 178.4
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 177.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 177.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 173.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 172.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 169.8
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 169.2
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 168.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 168.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 166.3
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 165.3
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 163.9
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 163.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 163.1
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 161.4
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 159.3
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 158.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 158.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 153.6
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 151.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 150.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 150.0
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 148.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 148.3
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 148.2
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 148.1
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 141.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 140.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 138.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 137.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 136.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 134.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 133.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 132.9
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 131.6
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 130.9
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 130.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 130.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 125.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 124.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 122.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 119.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 115.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 113.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 113.3
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 111.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 110.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 109.8
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 109.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 109.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 108.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 106.4
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 105.8
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 105.8
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 103.5
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 103.2
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 103.2
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 102.8
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 102.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 100.2
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 100.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 100.1
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 98.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 97.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 96.8
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 96.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 94.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 93.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 93.1
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 92.2
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 90.9
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 89.7
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 86.9
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 85.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 85.5
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 84.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 81.8
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 79.8
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 77.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 77.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 72.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 71.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 64.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 62.4
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 61.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 61.4
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 59.3
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 50.4
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 49.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 49.0
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 37.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 14.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 595.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 595.9
FF:10158-103A5 76 years, female 595.9

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 466.6
Pig sample Sample description nTPM
Midbrain
nTPM: 349.1
Samples: 4

Max nTPM: 477.5
Min nTPM: 280.3
Sample A Female 303.7
Sample B Female 477.5
Sample C Male 335.0
Sample D Male 280.3
Periaqueductal gray
nTPM: 466.6
Samples: 3

Max nTPM: 528.7
Min nTPM: 379.1
Sample B Female 492.0
Sample C Male 528.7
Sample D Male 379.1
Substantia nigra
nTPM: 347.4
Samples: 4

Max nTPM: 423.3
Min nTPM: 278.3
Sample A Female 397.6
Sample B Female 290.2
Sample C Male 423.3
Sample D Male 278.3
Superior colliculi
nTPM: 267.9
Samples: 4

Max nTPM: 322.8
Min nTPM: 150.3
Sample A Female 322.8
Sample B Female 150.3
Sample C Male 289.4
Sample D Male 309.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 163.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 163.3
Samples: 4

Max nTPM: 169.5
Min nTPM: 158.8
Sample A Male 169.5
Sample B Male 158.8
Sample C Female 159.8
Sample D Female 165.0

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.9
77620233 Antisense, RP_070129_03_B08, Mouse strain C57BL/6J (56 days, male) 0.9

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