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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:1949.4 nTPM
HPA:1949.4 nTPM
GTEx:434.4 nTPM
FANTOM5:561.0 Scaled Tags Per Million
Pig:1123.1 nTPM
Mouse:2313.6 nTPM
Allen mouse:5.8 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 1949.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 1457.9
2411 Female, age 72, unknown 1612.5
1870 Female, age 42, unknown 1546.7
1827 Male, age 72, unknown 1531.1
2219 Male, age 76, both hemispheres 1523.2
1833 Male, age 53, unknown 1473.7
2586 Male, age 75, left hemisphere 1414.8
1830 Male, age 51, unknown 1405.1
2666 Male, age 74, left hemisphere 1403.6
2019 Male, age 18, unknown 1343.1
2828 Female, age 72, unknown 1325.4
Dorsal raphe nucleus
nTPM: 1696.2
2047 Male, age 72, unknown 1961.0
2298 Female, age 72, unknown 1917.0
2750 Male, age 76, both hemispheres 1654.4
1828 Male, age 53, unknown 1517.6
2016 Female, age 72, unknown 1431.1
Inferior colliculus
nTPM: 1619.2
1848 Female, age 42, unknown 1725.1
2097 Female, age 72, unknown 1618.3
2849 Male, age 72, unknown 1615.2
1890 Male, age 53, unknown 1518.0
Median raphe nucleus
nTPM: 1949.4
2220 Male, age 76, midline 1949.4
Pedunculopontine tegmental nucleus
nTPM: 1579.7
2334 Male, age 80, both hemispheres 1680.7
1921 Female, age 85, both hemispheres 1619.8
2338 Male, age 61, both hemispheres 1438.7
Periaquaductal grey, anterior
nTPM: 1476.5
1795 Male, age 51, unknown 1517.8
2502 Female, age 75, unknown 1459.8
1947 Male, age 18, unknown 1451.8
Periaquaductal grey, dorsal
nTPM: 1515.0
1840 Male, age 53, unknown 1677.6
2850 Male, age 76, both hemispheres 1511.8
2464 Female, age 72, unknown 1500.5
1831 Male, age 72, unknown 1370.1
Periaquaductal grey, lateral
nTPM: 1454.9
2272 Male, age 74, both hemispheres 1463.7
2053 Male, age 18, unknown 1462.9
2140 Male, age 76, both hemispheres 1438.2
Pretectal area
nTPM: 1460.3
2224 Female, age 72, unknown 1673.8
1944 Female, age 72, unknown 1541.4
2007 Male, age 72, unknown 1528.9
2825 Male, age 18, unknown 1510.8
2667 Female, age 75, unknown 1440.5
1817 Female, age 42, unknown 1439.4
1816 Male, age 51, unknown 1427.5
2316 Male, age 76, right hemisphere 1416.8
2273 Male, age 74, both hemispheres 1413.2
1815 Male, age 53, unknown 1361.4
2407 Male, age 75, both hemispheres 1309.9
Red nucleus
nTPM: 1348.9
1821 Female, age 72, unknown 1434.2
2769 Male, age 72, unknown 1385.2
2227 Male, age 72, unknown 1384.4
2785 Male, age 18, unknown 1376.8
1954 Female, age 42, unknown 1366.5
2503 Female, age 72, unknown 1350.4
2725 Female, age 75, unknown 1344.1
2584 Male, age 75, left hemisphere 1337.2
2588 Male, age 74, left hemisphere 1323.8
1904 Male, age 53, unknown 1320.0
1865 Male, age 51, unknown 1304.0
2823 Male, age 76, right hemisphere 1260.3
Substantia nigra
nTPM: 1461.8
1889 Female, age 72, unknown 1575.2
1916 Female, age 42, unknown 1544.0
1941 Male, age 53, unknown 1537.2
2699 Male, age 18, unknown 1488.2
2665 Male, age 74, both hemispheres 1477.4
1851 Male, age 51, unknown 1472.3
2590 Female, age 75, unknown 1422.2
2241 Male, age 72, unknown 1409.1
2583 Male, age 75, right hemisphere 1348.1
2409 Female, age 72, unknown 1344.1
Superior colliculus
nTPM: 1416.0
1895 Male, age 76, right hemisphere 1545.0
1796 Male, age 53, unknown 1518.5
1839 Male, age 51, unknown 1507.7
2668 Female, age 75, unknown 1466.6
2087 Female, age 72, unknown 1428.6
2587 Male, age 74, left hemisphere 1423.3
2261 Male, age 18, unknown 1415.5
2664 Male, age 75, both hemispheres 1375.1
1913 Female, age 42, unknown 1241.0
1995 Male, age 72, unknown 1238.9
Ventral tegmental area
nTPM: 1508.3
2410 Female, age 72, unknown 1572.6
1915 Female, age 42, unknown 1564.2
2218 Male, age 76, both hemispheres 1516.6
2021 Male, age 53, unknown 1488.0
1942 Male, age 51, unknown 1475.0
2223 Female, age 72, unknown 1433.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 434.4
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 434.4
Samples: 139

Max nTPM: 1663.6
Min nTPM: 164.9
Std nTPM: 213.8
Median nTPM: 365.5
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 1663.6
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 1360.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 979.3
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 919.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 886.8
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 867.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 855.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 851.7
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 807.5
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 763.6
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 763.1
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 723.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 721.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 714.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 710.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 691.5
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 681.7
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 674.2
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 664.3
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 663.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 661.7
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 585.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 580.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 579.5
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 570.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 561.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 561.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 542.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 540.6
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 529.9
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 522.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 518.8
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 512.2
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 511.5
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 506.8
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 502.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 499.1
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 491.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 474.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 471.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 470.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 457.7
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 443.4
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 438.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 438.4
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 435.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 434.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 433.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 429.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 425.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 419.1
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 414.7
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 411.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 408.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 408.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 407.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 407.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 402.9
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 395.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 391.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 389.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 385.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 382.9
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 382.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 379.4
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 378.9
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 374.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 374.3
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 366.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 365.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 364.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 362.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 361.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 359.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 356.1
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 352.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 350.9
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 349.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 349.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 344.2
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 342.4
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 342.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 341.8
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 340.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 339.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 337.4
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 337.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 336.0
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 333.4
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 332.7
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 330.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 326.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 326.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 324.9
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 319.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 318.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 316.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 314.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 310.3
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 309.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 304.5
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 302.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 300.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 299.7
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 299.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 298.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 298.1
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 297.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 295.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 294.4
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 291.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 284.9
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 284.2
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 281.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 277.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 275.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 273.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 271.6
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 269.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 268.4
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 268.4
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 268.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 268.0
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 264.4
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 262.7
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 262.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 256.0
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 252.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 250.4
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 248.8
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 243.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 241.4
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 231.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 231.3
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 228.4
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 213.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 201.0
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 189.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 164.9
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 561.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 561.0
FF:10158-103A5 76 years, female 561.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1123.1
Pig sample Sample description nTPM
Midbrain
nTPM: 1115.3
Samples: 4

Max nTPM: 1311.1
Min nTPM: 945.6
Sample A Female 1033.9
Sample B Female 945.6
Sample C Male 1170.6
Sample D Male 1311.1
Periaqueductal gray
nTPM: 1063.5
Samples: 3

Max nTPM: 1411.4
Min nTPM: 854.3
Sample B Female 924.7
Sample C Male 1411.4
Sample D Male 854.3
Substantia nigra
nTPM: 1034.3
Samples: 4

Max nTPM: 1307.1
Min nTPM: 758.1
Sample A Female 1222.7
Sample B Female 849.3
Sample C Male 1307.1
Sample D Male 758.1
Superior colliculi
nTPM: 1123.1
Samples: 4

Max nTPM: 1360.2
Min nTPM: 875.8
Sample A Female 1205.0
Sample B Female 875.8
Sample C Male 1360.2
Sample D Male 1051.2

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 2313.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 2313.6
Samples: 4

Max nTPM: 2363.4
Min nTPM: 2254.0
Sample A Male 2254.0
Sample B Male 2363.4
Sample C Female 2281.1
Sample D Female 2355.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 5.8
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 5.8
509 Antisense, RP_040507_01_H03, Mouse strain C57BL/6J (56 days, male) 17.3
510 Antisense, RP_040507_01_H03, Mouse strain C57BL/6J (56 days, male) 12.7
70230813 Antisense, RP_050524_04_E07, Mouse strain C57BL/6J (56 days, male) 0.0
511 Sense, RPS_Baylor_36998, Mouse strain C57BL/6J (56 days, male) 0.0

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