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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:148.7 nTPM
HPA:148.7 nTPM
GTEx:124.1 nTPM
FANTOM5:43.9 Scaled Tags Per Million
Pig:225.0 nTPM
Mouse:150.4 nTPM
Allen mouse:7.1 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 148.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 125.7
2586 Male, age 75, left hemisphere 133.2
1833 Male, age 53, unknown 132.1
2666 Male, age 74, left hemisphere 129.9
1870 Female, age 42, unknown 129.3
2411 Female, age 72, unknown 128.1
1830 Male, age 51, unknown 126.9
2219 Male, age 76, both hemispheres 124.6
2828 Female, age 72, unknown 123.2
1827 Male, age 72, unknown 119.5
2019 Male, age 18, unknown 109.9
Dorsal raphe nucleus
nTPM: 131.0
2047 Male, age 72, unknown 147.7
2750 Male, age 76, both hemispheres 134.6
2298 Female, age 72, unknown 131.1
1828 Male, age 53, unknown 126.8
2016 Female, age 72, unknown 114.9
Inferior colliculus
nTPM: 117.7
2849 Male, age 72, unknown 125.1
1848 Female, age 42, unknown 124.0
2097 Female, age 72, unknown 111.7
1890 Male, age 53, unknown 109.9
Median raphe nucleus
nTPM: 148.7
2220 Male, age 76, midline 148.7
Pedunculopontine tegmental nucleus
nTPM: 120.1
1921 Female, age 85, both hemispheres 123.8
2334 Male, age 80, both hemispheres 122.8
2338 Male, age 61, both hemispheres 113.9
Periaquaductal grey, anterior
nTPM: 129.1
1947 Male, age 18, unknown 141.3
2502 Female, age 75, unknown 129.2
1795 Male, age 51, unknown 116.8
Periaquaductal grey, dorsal
nTPM: 119.1
1840 Male, age 53, unknown 134.0
2464 Female, age 72, unknown 118.1
2850 Male, age 76, both hemispheres 113.6
1831 Male, age 72, unknown 110.7
Periaquaductal grey, lateral
nTPM: 109.1
2053 Male, age 18, unknown 110.8
2140 Male, age 76, both hemispheres 109.7
2272 Male, age 74, both hemispheres 106.6
Pretectal area
nTPM: 114.5
2825 Male, age 18, unknown 122.2
1817 Female, age 42, unknown 119.7
2224 Female, age 72, unknown 117.1
2667 Female, age 75, unknown 116.9
1815 Male, age 53, unknown 116.7
1816 Male, age 51, unknown 115.9
2007 Male, age 72, unknown 115.6
2407 Male, age 75, both hemispheres 112.5
1944 Female, age 72, unknown 111.8
2316 Male, age 76, right hemisphere 106.9
2273 Male, age 74, both hemispheres 103.8
Red nucleus
nTPM: 112.8
2584 Male, age 75, left hemisphere 118.4
2769 Male, age 72, unknown 116.6
2503 Female, age 72, unknown 116.1
2588 Male, age 74, left hemisphere 115.8
1821 Female, age 72, unknown 115.6
2227 Male, age 72, unknown 113.3
2725 Female, age 75, unknown 111.9
1954 Female, age 42, unknown 111.1
1865 Male, age 51, unknown 110.8
1904 Male, age 53, unknown 110.4
2785 Male, age 18, unknown 109.8
2823 Male, age 76, right hemisphere 103.7
Substantia nigra
nTPM: 129.7
1916 Female, age 42, unknown 152.1
2665 Male, age 74, both hemispheres 149.4
1851 Male, age 51, unknown 145.1
2699 Male, age 18, unknown 131.9
2409 Female, age 72, unknown 124.2
1889 Female, age 72, unknown 122.7
2241 Male, age 72, unknown 120.3
2583 Male, age 75, right hemisphere 117.8
2590 Female, age 75, unknown 117.6
1941 Male, age 53, unknown 115.9
Superior colliculus
nTPM: 116.4
1796 Male, age 53, unknown 124.2
2668 Female, age 75, unknown 123.8
2664 Male, age 75, both hemispheres 123.6
1895 Male, age 76, right hemisphere 116.0
1839 Male, age 51, unknown 114.1
1913 Female, age 42, unknown 113.8
2087 Female, age 72, unknown 113.0
2261 Male, age 18, unknown 112.5
2587 Male, age 74, left hemisphere 112.3
1995 Male, age 72, unknown 111.0
Ventral tegmental area
nTPM: 137.0
2223 Female, age 72, unknown 146.8
1915 Female, age 42, unknown 144.4
1942 Male, age 51, unknown 135.9
2410 Female, age 72, unknown 135.4
2021 Male, age 53, unknown 130.9
2218 Male, age 76, both hemispheres 128.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 124.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 124.1
Samples: 139

Max nTPM: 223.6
Min nTPM: 75.5
Std nTPM: 29.0
Median nTPM: 120.3
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 223.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 216.3
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 203.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 198.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 193.7
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 192.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 187.8
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 187.6
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 183.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 176.9
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 169.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 166.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 161.8
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 160.8
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 160.7
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 158.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 155.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 153.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 151.1
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 150.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 150.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 150.2
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 149.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 149.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 147.3
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 145.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 144.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 141.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 141.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 141.0
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 141.0
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 140.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 140.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 138.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 137.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 137.6
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 137.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 136.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 136.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 136.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 136.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 134.8
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 134.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 133.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 132.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 132.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 132.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 131.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 131.3
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 130.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 129.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 128.9
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 128.7
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 128.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 128.1
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 127.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 126.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 126.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 126.5
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 126.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 125.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 125.4
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 124.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 124.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 123.1
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 122.3
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 121.4
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 120.9
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 120.4
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 120.3
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 120.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 119.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 118.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 118.3
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 118.3
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 116.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 116.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 116.1
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 116.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 115.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 114.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 112.3
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 112.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 111.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 111.3
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 111.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 110.4
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 110.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 109.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 109.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 108.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 107.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 107.2
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 106.1
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 105.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 105.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 105.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 105.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 104.6
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 104.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 104.3
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 104.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 103.6
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 102.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 102.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 102.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 101.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 100.3
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 99.5
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 99.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 99.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 99.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 98.6
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 98.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 97.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 97.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 97.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 96.8
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 96.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 96.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 95.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 95.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 94.7
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 93.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 93.5
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 91.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 91.6
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 91.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 90.0
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 89.1
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 88.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 88.3
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 87.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 85.6
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 81.6
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 81.2
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 80.8
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 79.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 75.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 43.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 43.9
FF:10158-103A5 76 years, female 43.9

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 225.0
Pig sample Sample description nTPM
Midbrain
nTPM: 216.1
Samples: 4

Max nTPM: 383.5
Min nTPM: 127.2
Sample A Female 383.5
Sample B Female 198.4
Sample C Male 155.2
Sample D Male 127.2
Periaqueductal gray
nTPM: 159.5
Samples: 3

Max nTPM: 168.8
Min nTPM: 148.3
Sample B Female 168.8
Sample C Male 161.4
Sample D Male 148.3
Substantia nigra
nTPM: 225.0
Samples: 4

Max nTPM: 252.9
Min nTPM: 165.9
Sample A Female 252.9
Sample B Female 165.9
Sample C Male 238.7
Sample D Male 242.4
Superior colliculi
nTPM: 171.4
Samples: 4

Max nTPM: 197.7
Min nTPM: 121.2
Sample A Female 196.2
Sample B Female 121.2
Sample C Male 170.3
Sample D Male 197.7

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 150.4
Mouse sample Sample description nTPM
Midbrain
nTPM: 150.4
Samples: 4

Max nTPM: 157.4
Min nTPM: 145.5
Sample A Male 157.4
Sample B Male 146.2
Sample C Female 145.5
Sample D Female 152.6

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 7.1
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 7.1
32576 Antisense, RP_040324_01_D11, Mouse strain C57BL/6J (56 days, male) 11.3
71608206 Antisense, RP_050927_01_B02, Mouse strain C57BL/6J (56 days, male) 2.9

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