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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:838.7 nTPM
HPA:838.7 nTPM
GTEx:613.9 nTPM
FANTOM5:970.7 Scaled Tags Per Million
Pig:214.4 nTPM
Mouse:6.0 nTPM
Allen mouse:0.0 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 838.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 782.1
2666 Male, age 74, left hemisphere 867.1
2828 Female, age 72, unknown 838.7
2586 Male, age 75, left hemisphere 796.9
2019 Male, age 18, unknown 779.5
1827 Male, age 72, unknown 777.4
2219 Male, age 76, both hemispheres 763.9
1830 Male, age 51, unknown 753.0
2411 Female, age 72, unknown 753.0
1833 Male, age 53, unknown 748.4
1870 Female, age 42, unknown 743.1
Dorsal raphe nucleus
nTPM: 809.4
2047 Male, age 72, unknown 854.2
2298 Female, age 72, unknown 819.5
2016 Female, age 72, unknown 815.8
1828 Male, age 53, unknown 815.7
2750 Male, age 76, both hemispheres 741.9
Inferior colliculus
nTPM: 751.6
2849 Male, age 72, unknown 771.2
1848 Female, age 42, unknown 752.9
1890 Male, age 53, unknown 752.0
2097 Female, age 72, unknown 730.2
Median raphe nucleus
nTPM: 801.1
2220 Male, age 76, midline 801.1
Pedunculopontine tegmental nucleus
nTPM: 801.9
2334 Male, age 80, both hemispheres 873.6
2338 Male, age 61, both hemispheres 797.7
1921 Female, age 85, both hemispheres 734.4
Periaquaductal grey, anterior
nTPM: 804.9
1795 Male, age 51, unknown 849.8
1947 Male, age 18, unknown 792.2
2502 Female, age 75, unknown 772.8
Periaquaductal grey, dorsal
nTPM: 805.0
2850 Male, age 76, both hemispheres 924.3
1831 Male, age 72, unknown 766.6
1840 Male, age 53, unknown 765.5
2464 Female, age 72, unknown 763.6
Periaquaductal grey, lateral
nTPM: 838.7
2140 Male, age 76, both hemispheres 934.5
2272 Male, age 74, both hemispheres 796.1
2053 Male, age 18, unknown 785.5
Pretectal area
nTPM: 813.9
2007 Male, age 72, unknown 843.2
1817 Female, age 42, unknown 836.5
2407 Male, age 75, both hemispheres 828.5
1944 Female, age 72, unknown 824.0
2667 Female, age 75, unknown 822.3
2316 Male, age 76, right hemisphere 816.4
1816 Male, age 51, unknown 813.4
2273 Male, age 74, both hemispheres 809.6
2224 Female, age 72, unknown 797.2
2825 Male, age 18, unknown 789.6
1815 Male, age 53, unknown 772.1
Red nucleus
nTPM: 778.9
2725 Female, age 75, unknown 860.2
2785 Male, age 18, unknown 821.0
2503 Female, age 72, unknown 809.8
2769 Male, age 72, unknown 785.1
2227 Male, age 72, unknown 784.3
2823 Male, age 76, right hemisphere 776.7
1865 Male, age 51, unknown 775.0
1954 Female, age 42, unknown 767.1
1821 Female, age 72, unknown 763.2
1904 Male, age 53, unknown 747.7
2584 Male, age 75, left hemisphere 735.0
2588 Male, age 74, left hemisphere 721.6
Substantia nigra
nTPM: 791.7
1941 Male, age 53, unknown 838.5
1851 Male, age 51, unknown 836.3
1889 Female, age 72, unknown 817.2
2699 Male, age 18, unknown 812.0
1916 Female, age 42, unknown 808.1
2409 Female, age 72, unknown 782.5
2590 Female, age 75, unknown 772.6
2583 Male, age 75, right hemisphere 765.3
2665 Male, age 74, both hemispheres 757.7
2241 Male, age 72, unknown 727.2
Superior colliculus
nTPM: 785.5
1796 Male, age 53, unknown 855.6
2664 Male, age 75, both hemispheres 818.9
2087 Female, age 72, unknown 787.6
2261 Male, age 18, unknown 787.5
1995 Male, age 72, unknown 780.3
1913 Female, age 42, unknown 771.1
1895 Male, age 76, right hemisphere 769.8
1839 Male, age 51, unknown 768.4
2587 Male, age 74, left hemisphere 764.5
2668 Female, age 75, unknown 751.5
Ventral tegmental area
nTPM: 788.9
2021 Male, age 53, unknown 810.2
1915 Female, age 42, unknown 809.8
2410 Female, age 72, unknown 800.7
2218 Male, age 76, both hemispheres 781.9
2223 Female, age 72, unknown 776.7
1942 Male, age 51, unknown 754.1

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 613.9
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 613.9
Samples: 139

Max nTPM: 7956.5
Min nTPM: 60.8
Std nTPM: 1009.6
Median nTPM: 310.1
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 7956.5
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 6141.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 5358.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 3291.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 2668.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 1903.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 1877.5
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 1691.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 1649.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 1631.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 1626.9
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 1624.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 1516.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 1175.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 1094.6
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 1047.3
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 1043.1
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 924.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 879.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 833.5
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 820.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 766.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 744.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 734.5
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 732.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 688.3
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 682.0
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 679.4
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 621.1
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 613.2
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 589.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 570.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 568.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 549.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 545.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 539.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 530.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 522.1
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 488.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 485.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 482.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 480.9
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 475.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 464.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 464.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 458.6
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 456.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 451.4
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 451.0
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 444.4
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 443.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 438.9
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 438.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 430.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 416.8
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 406.2
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 397.1
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 388.0
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 384.9
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 381.1
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 374.5
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 363.0
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 362.6
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 359.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 335.2
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 323.5
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 321.7
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 315.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 315.0
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 310.1
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 307.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 296.3
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 292.0
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 291.4
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 289.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 287.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 279.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 277.7
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 269.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 268.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 264.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 261.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 261.2
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 260.4
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 260.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 259.3
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 257.5
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 254.5
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 253.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 253.4
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 252.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 251.5
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 250.2
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 249.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 244.0
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 242.6
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 241.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 240.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 240.4
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 240.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 236.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 233.7
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 231.0
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 226.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 224.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 224.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 223.1
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 213.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 211.3
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 209.4
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 208.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 207.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 196.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 195.5
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 193.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 193.5
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 191.6
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 187.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 187.0
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 181.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 176.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 173.9
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 173.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 173.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 170.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 169.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 155.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 151.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 149.9
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 148.7
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 148.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 147.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 144.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 139.0
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 116.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 114.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 104.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 103.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 60.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 970.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 970.7
FF:10158-103A5 76 years, female 970.7

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 214.4
Pig sample Sample description nTPM
Midbrain
nTPM: 190.2
Samples: 4

Max nTPM: 271.3
Min nTPM: 139.9
Sample A Female 271.3
Sample B Female 165.8
Sample C Male 183.8
Sample D Male 139.9
Periaqueductal gray
nTPM: 168.2
Samples: 3

Max nTPM: 180.5
Min nTPM: 159.2
Sample B Female 164.9
Sample C Male 180.5
Sample D Male 159.2
Substantia nigra
nTPM: 208.6
Samples: 4

Max nTPM: 301.0
Min nTPM: 136.9
Sample A Female 301.0
Sample B Female 197.0
Sample C Male 199.5
Sample D Male 136.9
Superior colliculi
nTPM: 214.4
Samples: 4

Max nTPM: 267.9
Min nTPM: 151.9
Sample A Female 263.0
Sample B Female 267.9
Sample C Male 151.9
Sample D Male 174.7

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 6.0
Mouse sample Sample description nTPM
Midbrain
nTPM: 6.1
Samples: 4

Max nTPM: 6.7
Min nTPM: 5.6
Sample A Male 6.0
Sample B Male 5.6
Sample C Female 5.9
Sample D Female 6.7

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.0
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.0
74363357 Antisense, RP_051121_02_H03, Mouse strain C57BL/6J (56 days, male) 0.0
73514683 Antisense, RP_051121_02_H03, Mouse strain C57BL/6J (56 days, male) 0.0

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