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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:564.2 nTPM
HPA:564.2 nTPM
GTEx:629.7 nTPM
FANTOM5:1391.6 Scaled Tags Per Million
Pig:1025.5 nTPM
Mouse:1799.2 nTPM
Allen mouse:21.2 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 564.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 479.5
2219 Male, age 76, both hemispheres 678.5
2019 Male, age 18, unknown 559.4
2411 Female, age 72, unknown 532.2
1827 Male, age 72, unknown 480.3
1870 Female, age 42, unknown 455.1
1833 Male, age 53, unknown 445.7
2828 Female, age 72, unknown 431.4
1830 Male, age 51, unknown 429.0
2666 Male, age 74, left hemisphere 405.9
2586 Male, age 75, left hemisphere 377.2
Dorsal raphe nucleus
nTPM: 513.8
2298 Female, age 72, unknown 606.1
2047 Male, age 72, unknown 541.5
1828 Male, age 53, unknown 515.6
2750 Male, age 76, both hemispheres 461.4
2016 Female, age 72, unknown 444.3
Inferior colliculus
nTPM: 461.2
2097 Female, age 72, unknown 497.7
1848 Female, age 42, unknown 458.0
1890 Male, age 53, unknown 456.6
2849 Male, age 72, unknown 432.3
Median raphe nucleus
nTPM: 510.5
2220 Male, age 76, midline 510.5
Pedunculopontine tegmental nucleus
nTPM: 504.2
2334 Male, age 80, both hemispheres 517.7
2338 Male, age 61, both hemispheres 506.2
1921 Female, age 85, both hemispheres 488.6
Periaquaductal grey, anterior
nTPM: 456.8
1947 Male, age 18, unknown 471.1
1795 Male, age 51, unknown 459.0
2502 Female, age 75, unknown 440.3
Periaquaductal grey, dorsal
nTPM: 441.5
1840 Male, age 53, unknown 462.0
2850 Male, age 76, both hemispheres 443.5
2464 Female, age 72, unknown 430.8
1831 Male, age 72, unknown 429.7
Periaquaductal grey, lateral
nTPM: 433.5
2272 Male, age 74, both hemispheres 494.5
2053 Male, age 18, unknown 405.6
2140 Male, age 76, both hemispheres 400.4
Pretectal area
nTPM: 511.6
1944 Female, age 72, unknown 594.2
1817 Female, age 42, unknown 588.4
2007 Male, age 72, unknown 574.0
1816 Male, age 51, unknown 556.3
2667 Female, age 75, unknown 536.1
2273 Male, age 74, both hemispheres 516.8
1815 Male, age 53, unknown 515.0
2224 Female, age 72, unknown 509.4
2407 Male, age 75, both hemispheres 465.3
2825 Male, age 18, unknown 419.9
2316 Male, age 76, right hemisphere 352.3
Red nucleus
nTPM: 452.2
1821 Female, age 72, unknown 533.8
2785 Male, age 18, unknown 509.1
1954 Female, age 42, unknown 475.2
1865 Male, age 51, unknown 470.6
2725 Female, age 75, unknown 462.3
1904 Male, age 53, unknown 452.1
2503 Female, age 72, unknown 450.5
2769 Male, age 72, unknown 431.1
2227 Male, age 72, unknown 428.5
2588 Male, age 74, left hemisphere 413.0
2584 Male, age 75, left hemisphere 407.9
2823 Male, age 76, right hemisphere 392.5
Substantia nigra
nTPM: 564.2
1916 Female, age 42, unknown 701.7
2241 Male, age 72, unknown 641.8
1851 Male, age 51, unknown 609.8
1941 Male, age 53, unknown 606.2
1889 Female, age 72, unknown 588.0
2409 Female, age 72, unknown 577.1
2699 Male, age 18, unknown 490.5
2590 Female, age 75, unknown 489.5
2665 Male, age 74, both hemispheres 476.3
2583 Male, age 75, right hemisphere 461.4
Superior colliculus
nTPM: 447.4
2087 Female, age 72, unknown 516.6
2587 Male, age 74, left hemisphere 487.3
2668 Female, age 75, unknown 478.0
1796 Male, age 53, unknown 473.5
2261 Male, age 18, unknown 465.3
1895 Male, age 76, right hemisphere 428.9
1839 Male, age 51, unknown 423.1
1913 Female, age 42, unknown 415.9
2664 Male, age 75, both hemispheres 398.1
1995 Male, age 72, unknown 387.0
Ventral tegmental area
nTPM: 523.8
2410 Female, age 72, unknown 638.6
2218 Male, age 76, both hemispheres 555.5
1915 Female, age 42, unknown 554.0
2223 Female, age 72, unknown 480.6
1942 Male, age 51, unknown 475.4
2021 Male, age 53, unknown 438.9

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 629.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 629.7
Samples: 139

Max nTPM: 1729.9
Min nTPM: 242.5
Std nTPM: 278.5
Median nTPM: 553.4
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 1729.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 1522.4
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 1508.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 1502.9
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 1398.8
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 1243.7
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 1197.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 1161.1
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 1140.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1130.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 1101.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 1046.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 1037.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 1026.3
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 1025.1
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 990.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 959.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 956.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 953.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 951.9
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 939.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 889.3
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 846.4
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 830.2
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 816.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 806.8
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 796.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 784.7
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 769.9
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 761.6
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 760.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 750.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 748.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 748.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 728.9
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 727.2
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 726.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 724.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 721.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 702.7
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 700.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 700.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 698.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 693.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 680.4
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 676.8
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 667.1
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 655.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 652.1
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 651.2
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 647.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 636.9
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 633.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 630.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 622.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 621.1
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 620.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 616.8
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 602.7
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 600.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 595.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 587.9
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 578.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 570.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 566.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 561.6
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 561.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 558.7
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 556.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 553.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 552.9
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 551.7
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 548.3
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 547.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 546.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 546.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 538.4
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 528.7
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 525.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 524.0
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 517.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 517.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 509.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 506.1
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 499.8
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 480.1
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 478.0
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 474.4
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 471.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 471.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 469.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 465.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 462.7
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 460.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 460.0
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 458.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 455.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 448.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 447.2
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 446.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 445.3
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 444.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 443.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 441.8
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 441.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 433.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 433.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 431.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 430.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 429.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 423.3
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 422.3
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 412.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 410.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 401.4
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 398.1
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 390.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 388.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 384.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 384.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 379.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 379.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 379.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 378.9
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 370.1
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 366.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 363.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 361.4
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 358.6
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 332.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 331.2
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 317.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 307.8
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 302.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 301.2
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 299.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 296.3
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 289.6
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 242.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 1391.6
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 1391.6
FF:10158-103A5 76 years, female 1391.6

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1025.5
Pig sample Sample description nTPM
Midbrain
nTPM: 970.1
Samples: 4

Max nTPM: 1213.7
Min nTPM: 815.2
Sample A Female 975.7
Sample B Female 815.2
Sample C Male 1213.7
Sample D Male 875.9
Periaqueductal gray
nTPM: 745.6
Samples: 3

Max nTPM: 825.1
Min nTPM: 696.2
Sample B Female 696.2
Sample C Male 825.1
Sample D Male 715.4
Substantia nigra
nTPM: 931.0
Samples: 4

Max nTPM: 1352.7
Min nTPM: 644.1
Sample A Female 1352.7
Sample B Female 743.6
Sample C Male 983.5
Sample D Male 644.1
Superior colliculi
nTPM: 1025.5
Samples: 4

Max nTPM: 1341.3
Min nTPM: 724.4
Sample A Female 1072.5
Sample B Female 724.4
Sample C Male 1341.3
Sample D Male 963.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1799.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 1799.2
Samples: 4

Max nTPM: 1854.2
Min nTPM: 1684.1
Sample A Male 1684.1
Sample B Male 1854.2
Sample C Female 1836.4
Sample D Female 1822.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 21.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 21.2
75694450 Antisense, RP_060518_03_G08, Mouse strain C57BL/6J (56 days, male) 21.2

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