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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:72.0 nTPM
HPA:72.0 nTPM
GTEx:63.7 nTPM
FANTOM5:38.9 Scaled Tags Per Million
Pig:58.0 nTPM
Mouse:107.9 nTPM
Allen mouse:19.9 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 72.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 66.0
2019 Male, age 18, unknown 72.2
1827 Male, age 72, unknown 71.5
2586 Male, age 75, left hemisphere 70.5
2666 Male, age 74, left hemisphere 69.0
2828 Female, age 72, unknown 67.4
2411 Female, age 72, unknown 65.7
2219 Male, age 76, both hemispheres 62.8
1870 Female, age 42, unknown 61.1
1830 Male, age 51, unknown 59.8
1833 Male, age 53, unknown 59.8
Dorsal raphe nucleus
nTPM: 62.2
2298 Female, age 72, unknown 66.1
1828 Male, age 53, unknown 64.6
2750 Male, age 76, both hemispheres 61.9
2047 Male, age 72, unknown 59.4
2016 Female, age 72, unknown 59.0
Inferior colliculus
nTPM: 61.7
2097 Female, age 72, unknown 67.3
1890 Male, age 53, unknown 62.1
1848 Female, age 42, unknown 59.5
2849 Male, age 72, unknown 57.8
Median raphe nucleus
nTPM: 63.8
2220 Male, age 76, midline 63.8
Pedunculopontine tegmental nucleus
nTPM: 63.1
2334 Male, age 80, both hemispheres 65.8
1921 Female, age 85, both hemispheres 65.2
2338 Male, age 61, both hemispheres 58.4
Periaquaductal grey, anterior
nTPM: 67.4
2502 Female, age 75, unknown 68.6
1795 Male, age 51, unknown 68.4
1947 Male, age 18, unknown 65.3
Periaquaductal grey, dorsal
nTPM: 59.2
1831 Male, age 72, unknown 63.2
2464 Female, age 72, unknown 58.4
2850 Male, age 76, both hemispheres 57.8
1840 Male, age 53, unknown 57.2
Periaquaductal grey, lateral
nTPM: 60.1
2272 Male, age 74, both hemispheres 62.6
2053 Male, age 18, unknown 60.4
2140 Male, age 76, both hemispheres 57.3
Pretectal area
nTPM: 72.0
1816 Male, age 51, unknown 87.3
2007 Male, age 72, unknown 83.3
1944 Female, age 72, unknown 83.2
1817 Female, age 42, unknown 80.9
1815 Male, age 53, unknown 76.5
2667 Female, age 75, unknown 73.6
2273 Male, age 74, both hemispheres 63.9
2407 Male, age 75, both hemispheres 62.4
2825 Male, age 18, unknown 61.7
2224 Female, age 72, unknown 61.3
2316 Male, age 76, right hemisphere 58.0
Red nucleus
nTPM: 64.8
2785 Male, age 18, unknown 70.8
1821 Female, age 72, unknown 69.2
2725 Female, age 75, unknown 67.0
2823 Male, age 76, right hemisphere 64.3
2588 Male, age 74, left hemisphere 64.2
1865 Male, age 51, unknown 63.9
2584 Male, age 75, left hemisphere 63.9
1904 Male, age 53, unknown 63.5
1954 Female, age 42, unknown 63.3
2503 Female, age 72, unknown 63.1
2227 Male, age 72, unknown 62.2
2769 Male, age 72, unknown 62.0
Substantia nigra
nTPM: 69.4
1916 Female, age 42, unknown 79.8
1889 Female, age 72, unknown 75.6
1941 Male, age 53, unknown 73.3
1851 Male, age 51, unknown 71.8
2409 Female, age 72, unknown 68.2
2665 Male, age 74, both hemispheres 67.5
2241 Male, age 72, unknown 66.6
2583 Male, age 75, right hemisphere 65.1
2699 Male, age 18, unknown 63.6
2590 Female, age 75, unknown 63.0
Superior colliculus
nTPM: 66.2
2087 Female, age 72, unknown 77.4
1796 Male, age 53, unknown 70.4
2261 Male, age 18, unknown 70.1
2664 Male, age 75, both hemispheres 67.1
2668 Female, age 75, unknown 66.0
2587 Male, age 74, left hemisphere 63.6
1895 Male, age 76, right hemisphere 62.7
1995 Male, age 72, unknown 62.1
1913 Female, age 42, unknown 61.9
1839 Male, age 51, unknown 60.9
Ventral tegmental area
nTPM: 65.9
2410 Female, age 72, unknown 72.9
1915 Female, age 42, unknown 69.2
2218 Male, age 76, both hemispheres 69.1
1942 Male, age 51, unknown 63.0
2223 Female, age 72, unknown 60.8
2021 Male, age 53, unknown 60.2

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 63.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 63.7
Samples: 139

Max nTPM: 144.8
Min nTPM: 32.2
Std nTPM: 19.1
Median nTPM: 60.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 144.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 126.4
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 125.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 124.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 121.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 102.9
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 102.6
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 96.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 92.7
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 91.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 91.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 90.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 89.3
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 86.1
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 85.6
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 85.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 83.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 83.6
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 81.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 79.7
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 78.7
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 78.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 77.9
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 77.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 76.8
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 75.9
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 75.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 75.4
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 75.0
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 74.5
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 74.3
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 73.9
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 72.4
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 72.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 72.3
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 71.9
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 71.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 71.6
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 70.8
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 70.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 69.5
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 69.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 68.3
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 67.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 67.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 67.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 66.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 66.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 66.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 66.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 65.8
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 65.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 65.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 65.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 65.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 64.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 64.6
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 64.4
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 63.5
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 63.4
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 63.0
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 62.3
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 61.9
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 61.9
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 61.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 61.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 60.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 60.9
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 60.9
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 60.1
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 59.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 59.3
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 59.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 58.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 58.6
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 58.6
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 58.5
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 58.1
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 56.9
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 56.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 56.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 56.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 56.4
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 56.4
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 55.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 55.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 55.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 55.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 55.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 55.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 55.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 54.8
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 54.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 54.7
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 54.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 53.9
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 53.8
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 53.8
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 53.6
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 52.9
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 52.8
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 52.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 52.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 52.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 52.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 51.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 51.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 51.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 51.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 51.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 49.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 49.1
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 48.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 47.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 47.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 47.0
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 46.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 46.6
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 45.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 45.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 45.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 44.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 44.0
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 44.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 43.9
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 43.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 43.7
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 43.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 43.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 42.9
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 42.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 38.8
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 38.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 38.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 36.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 36.1
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 35.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 34.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 32.2
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 38.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 38.9
FF:10158-103A5 76 years, female 38.9

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 58.0
Pig sample Sample description nTPM
Midbrain
nTPM: 49.9
Samples: 4

Max nTPM: 63.2
Min nTPM: 42.1
Sample A Female 42.6
Sample B Female 42.1
Sample C Male 63.2
Sample D Male 51.7
Periaqueductal gray
nTPM: 39.1
Samples: 3

Max nTPM: 45.9
Min nTPM: 34.6
Sample B Female 36.7
Sample C Male 45.9
Sample D Male 34.6
Substantia nigra
nTPM: 46.4
Samples: 4

Max nTPM: 60.4
Min nTPM: 29.6
Sample A Female 60.4
Sample B Female 36.5
Sample C Male 59.1
Sample D Male 29.6
Superior colliculi
nTPM: 58.1
Samples: 4

Max nTPM: 64.9
Min nTPM: 52.6
Sample A Female 62.0
Sample B Female 52.6
Sample C Male 64.9
Sample D Male 52.7

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 107.9
Mouse sample Sample description nTPM
Midbrain
nTPM: 107.9
Samples: 4

Max nTPM: 117.2
Min nTPM: 93.7
Sample A Male 114.2
Sample B Male 106.3
Sample C Female 93.7
Sample D Female 117.2

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 19.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 19.9
512762 Antisense, RP_040809_02_C12, Mouse strain C57BL/6J (56 days, male) 19.9

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