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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:83.8 nTPM
HPA:83.8 nTPM
GTEx:57.0 nTPM
FANTOM5:31.7 Scaled Tags Per Million
Pig:16.1 nTPM
Mouse:60.5 nTPM
Allen mouse:2.2 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 83.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 79.9
2586 Male, age 75, left hemisphere 89.6
2019 Male, age 18, unknown 81.7
2411 Female, age 72, unknown 81.3
1827 Male, age 72, unknown 79.4
2666 Male, age 74, left hemisphere 79.2
1833 Male, age 53, unknown 79.1
2828 Female, age 72, unknown 78.6
2219 Male, age 76, both hemispheres 77.2
1830 Male, age 51, unknown 76.8
1870 Female, age 42, unknown 76.3
Dorsal raphe nucleus
nTPM: 79.6
1828 Male, age 53, unknown 83.1
2047 Male, age 72, unknown 81.4
2016 Female, age 72, unknown 79.2
2750 Male, age 76, both hemispheres 77.5
2298 Female, age 72, unknown 76.9
Inferior colliculus
nTPM: 79.2
1890 Male, age 53, unknown 81.6
2097 Female, age 72, unknown 80.6
1848 Female, age 42, unknown 78.3
2849 Male, age 72, unknown 76.3
Median raphe nucleus
nTPM: 77.6
2220 Male, age 76, midline 77.6
Pedunculopontine tegmental nucleus
nTPM: 75.1
1921 Female, age 85, both hemispheres 79.0
2334 Male, age 80, both hemispheres 75.3
2338 Male, age 61, both hemispheres 71.1
Periaquaductal grey, anterior
nTPM: 79.1
1947 Male, age 18, unknown 80.2
2502 Female, age 75, unknown 79.7
1795 Male, age 51, unknown 77.3
Periaquaductal grey, dorsal
nTPM: 77.5
1840 Male, age 53, unknown 79.3
1831 Male, age 72, unknown 79.0
2464 Female, age 72, unknown 76.7
2850 Male, age 76, both hemispheres 74.9
Periaquaductal grey, lateral
nTPM: 76.3
2140 Male, age 76, both hemispheres 76.8
2053 Male, age 18, unknown 76.6
2272 Male, age 74, both hemispheres 75.5
Pretectal area
nTPM: 79.1
1944 Female, age 72, unknown 83.1
2007 Male, age 72, unknown 82.6
1817 Female, age 42, unknown 82.2
1816 Male, age 51, unknown 81.4
1815 Male, age 53, unknown 80.6
2667 Female, age 75, unknown 78.4
2407 Male, age 75, both hemispheres 77.8
2825 Male, age 18, unknown 77.1
2224 Female, age 72, unknown 76.9
2273 Male, age 74, both hemispheres 76.2
2316 Male, age 76, right hemisphere 73.3
Red nucleus
nTPM: 78.3
2588 Male, age 74, left hemisphere 83.5
1821 Female, age 72, unknown 81.2
2584 Male, age 75, left hemisphere 80.4
2785 Male, age 18, unknown 80.1
2769 Male, age 72, unknown 78.7
2725 Female, age 75, unknown 77.1
1865 Male, age 51, unknown 77.0
2503 Female, age 72, unknown 76.9
1954 Female, age 42, unknown 76.8
2227 Male, age 72, unknown 76.4
1904 Male, age 53, unknown 76.2
2823 Male, age 76, right hemisphere 75.9
Substantia nigra
nTPM: 83.8
1916 Female, age 42, unknown 93.4
1851 Male, age 51, unknown 88.8
2665 Male, age 74, both hemispheres 86.9
2241 Male, age 72, unknown 84.9
2583 Male, age 75, right hemisphere 83.2
2699 Male, age 18, unknown 83.0
1889 Female, age 72, unknown 82.5
2590 Female, age 75, unknown 80.0
1941 Male, age 53, unknown 79.1
2409 Female, age 72, unknown 75.9
Superior colliculus
nTPM: 78.3
2664 Male, age 75, both hemispheres 83.4
2668 Female, age 75, unknown 82.4
1796 Male, age 53, unknown 79.9
1839 Male, age 51, unknown 79.9
2087 Female, age 72, unknown 78.8
1895 Male, age 76, right hemisphere 77.8
2587 Male, age 74, left hemisphere 76.9
2261 Male, age 18, unknown 75.5
1995 Male, age 72, unknown 75.0
1913 Female, age 42, unknown 73.2
Ventral tegmental area
nTPM: 80.8
2410 Female, age 72, unknown 86.7
1915 Female, age 42, unknown 85.8
2218 Male, age 76, both hemispheres 80.5
1942 Male, age 51, unknown 78.2
2223 Female, age 72, unknown 77.1
2021 Male, age 53, unknown 76.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 57.0
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 57.0
Samples: 139

Max nTPM: 104.5
Min nTPM: 36.0
Std nTPM: 10.8
Median nTPM: 55.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 104.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 87.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 82.1
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 81.8
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 78.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 78.6
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 77.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 76.6
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 74.7
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 71.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 71.2
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 71.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 70.6
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 70.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 69.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 69.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 68.9
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 68.6
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 67.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 67.3
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 66.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 66.4
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 66.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 66.2
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 66.0
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 65.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 65.6
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 65.1
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 65.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 64.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 64.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 64.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 63.9
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 63.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 63.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 63.5
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 63.4
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 63.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 63.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 63.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 62.5
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 62.4
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 62.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 61.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 61.7
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 61.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 61.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 61.3
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 61.1
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 60.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 60.5
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 60.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 60.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 59.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 59.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 59.5
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 59.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 59.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 59.2
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 58.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 58.4
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 58.2
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 57.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 56.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 56.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 56.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 56.7
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 56.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 55.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 55.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 55.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 55.0
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 54.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 54.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 54.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 54.0
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 53.7
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 53.7
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 53.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 53.4
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 53.3
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 53.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 53.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 52.9
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 52.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 52.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 52.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 52.3
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 52.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 52.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 51.8
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 51.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 51.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 51.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 51.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 50.4
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 50.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 50.3
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 49.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 49.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 49.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 49.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 49.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 49.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 49.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 48.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 48.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 48.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 47.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 47.8
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 47.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 47.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 47.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 46.9
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 46.8
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 46.4
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 46.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 46.1
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 46.0
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 45.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 44.9
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 44.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 44.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 44.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 44.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 44.3
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 44.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 43.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 43.5
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 43.1
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 42.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 42.6
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 42.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 41.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 40.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 40.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 38.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 38.4
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 36.0
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 31.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 31.7
FF:10158-103A5 76 years, female 31.7

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 16.1
Pig sample Sample description nTPM
Midbrain
nTPM: 15.9
Samples: 4

Max nTPM: 17.9
Min nTPM: 12.8
Sample A Female 16.4
Sample B Female 12.8
Sample C Male 17.9
Sample D Male 16.6
Periaqueductal gray
nTPM: 13.3
Samples: 3

Max nTPM: 13.4
Min nTPM: 13.3
Sample B Female 13.3
Sample C Male 13.4
Sample D Male 13.3
Substantia nigra
nTPM: 14.5
Samples: 4

Max nTPM: 15.5
Min nTPM: 12.7
Sample A Female 14.6
Sample B Female 12.7
Sample C Male 15.0
Sample D Male 15.5
Superior colliculi
nTPM: 16.1
Samples: 4

Max nTPM: 18.6
Min nTPM: 13.8
Sample A Female 15.3
Sample B Female 13.8
Sample C Male 18.6
Sample D Male 16.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 60.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 60.6
Samples: 4

Max nTPM: 62.5
Min nTPM: 58.4
Sample A Male 60.7
Sample B Male 62.5
Sample C Female 58.4
Sample D Female 60.6

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.2
68193029 Antisense, RP_040825_01_F02, Mouse strain C57BL/6J (56 days, male) 2.2

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