Cell line - TSPAN31 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TSPAN31
Gene descriptionⁱ Full gene name according to HGNC.	Tetraspanin 31
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression based on cell line data from the DepMap portal and cell line data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Sarcoma - Muscle contraction (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cancer specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type. Read more	0.14
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines.The analyzed cell lines are grouped according to cancer type. Detailed information about the groups is revealed by hovering over the corresponding bar in the chart. More information and cell line data can be found in the Cell line section. Read more
Cell line categories Alphabetical Expression RNA specificity:Low cancer specificity

EXPRESSION CLUSTERING & CORRELATIONⁱ

TSPAN31 is part of cluster 42 Sarcoma - Muscle contraction with confidenceⁱ 1
184 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
OS9	OS9 endoplasmic reticulum lectin	0.6134	42
PIP4K2C	Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	0.5874	42
CTDSP2	CTD small phosphatase 2	0.5450	42
EEF1AKMT3	EEF1A lysine methyltransferase 3	0.5410	42
CDK4	Cyclin dependent kinase 4	0.5032	42
MARCHF9	Membrane associated ring-CH-type finger 9	0.4869	42
ARHGEF25	Rho guanine nucleotide exchange factor 25	0.4571	42
TBC1D3F	TBC1 domain family member 3F	0.4509	60
METTL1	Methyltransferase like 1	0.4436	42
WBP1	WW domain binding protein 1	0.4416	45
FAM3C	FAM3 metabolism regulating signaling molecule C	0.4357	60
CA3	Carbonic anhydrase 3	0.4285	42
CNOT2	CCR4-NOT transcription complex subunit 2	0.4273	45
DDIT3	DNA damage inducible transcript 3	0.4197	37
TSFM	Ts translation elongation factor, mitochondrial	0.4085	42

CELL LINE DATA

Alphabetical Expression Bile duct cancer (n=7)
Alphabetical Expression Bladder cancer (n=26)
Alphabetical Expression Bone cancer (n=19)
Alphabetical Expression Brain cancer (n=65)
Alphabetical Expression Breast cancer (n=50)
Alphabetical Expression Cervical cancer (n=3)
Alphabetical Expression Colorectal cancer (n=57)
Alphabetical Expression Esophageal cancer (n=27)
Alphabetical Expression Gallbladder cancer (n=1)
Alphabetical Expression Gastric cancer (n=38)
Alphabetical Expression Head and Neck cancer (n=33)
Alphabetical Expression Kidney cancer (n=31)
Alphabetical Expression Leukemia (n=88)
Alphabetical Expression Liver cancer (n=24)
Alphabetical Expression Lung cancer (n=196)
Alphabetical Expression Lymphoma (n=57)
Alphabetical Expression Myeloma (n=34)
Alphabetical Expression Neuroblastoma (n=17)
Alphabetical Expression Non-cancerous (n=60)
Alphabetical Expression Ovarian cancer (n=46)
Alphabetical Expression Pancreatic cancer (n=41)
Alphabetical Expression Prostate cancer (n=7)
Alphabetical Expression Rhabdoid (n=14)
Alphabetical Expression Sarcoma (n=14)
Alphabetical Expression Skin cancer (n=50)
Alphabetical Expression Testis cancer (n=1)
Alphabetical Expression Thyroid cancer (n=11)
Alphabetical Expression Uncategorized (n=10)
Alphabetical Expression Uterine cancer (n=28)