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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:152.6 nTPM
HPA:152.6 nTPM
GTEx:142.8 nTPM
FANTOM5:115.0 Scaled Tags Per Million
Pig:63.4 nTPM
Mouse:418.5 nTPM
Allen mouse:10.8 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 152.6
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 124.3
2586 Male, age 75, left hemisphere 171.9
1870 Female, age 42, unknown 136.6
1833 Male, age 53, unknown 133.5
2828 Female, age 72, unknown 130.2
1827 Male, age 72, unknown 128.7
1830 Male, age 51, unknown 120.0
2411 Female, age 72, unknown 113.9
2219 Male, age 76, both hemispheres 105.2
2666 Male, age 74, left hemisphere 104.8
2019 Male, age 18, unknown 97.9
Dorsal raphe nucleus
nTPM: 144.1
2016 Female, age 72, unknown 160.4
1828 Male, age 53, unknown 156.6
2298 Female, age 72, unknown 146.3
2047 Male, age 72, unknown 138.5
2750 Male, age 76, both hemispheres 118.9
Inferior colliculus
nTPM: 152.6
1848 Female, age 42, unknown 161.8
2097 Female, age 72, unknown 156.7
1890 Male, age 53, unknown 146.2
2849 Male, age 72, unknown 145.8
Median raphe nucleus
nTPM: 115.3
2220 Male, age 76, midline 115.3
Pedunculopontine tegmental nucleus
nTPM: 120.8
1921 Female, age 85, both hemispheres 128.4
2334 Male, age 80, both hemispheres 121.6
2338 Male, age 61, both hemispheres 112.3
Periaquaductal grey, anterior
nTPM: 146.4
1947 Male, age 18, unknown 181.0
1795 Male, age 51, unknown 133.2
2502 Female, age 75, unknown 125.0
Periaquaductal grey, dorsal
nTPM: 139.9
1840 Male, age 53, unknown 157.1
2850 Male, age 76, both hemispheres 141.6
2464 Female, age 72, unknown 138.6
1831 Male, age 72, unknown 122.2
Periaquaductal grey, lateral
nTPM: 141.3
2053 Male, age 18, unknown 163.2
2140 Male, age 76, both hemispheres 139.5
2272 Male, age 74, both hemispheres 121.3
Pretectal area
nTPM: 133.6
2667 Female, age 75, unknown 153.6
2825 Male, age 18, unknown 151.0
2273 Male, age 74, both hemispheres 145.0
2224 Female, age 72, unknown 144.4
1817 Female, age 42, unknown 135.9
1944 Female, age 72, unknown 134.1
2316 Male, age 76, right hemisphere 126.9
1816 Male, age 51, unknown 125.9
2407 Male, age 75, both hemispheres 121.6
1815 Male, age 53, unknown 118.4
2007 Male, age 72, unknown 112.1
Red nucleus
nTPM: 131.2
1821 Female, age 72, unknown 154.4
1954 Female, age 42, unknown 145.3
2769 Male, age 72, unknown 142.8
2227 Male, age 72, unknown 141.1
2503 Female, age 72, unknown 140.6
2823 Male, age 76, right hemisphere 134.8
2725 Female, age 75, unknown 134.3
1904 Male, age 53, unknown 130.9
1865 Male, age 51, unknown 127.1
2584 Male, age 75, left hemisphere 114.8
2588 Male, age 74, left hemisphere 112.5
2785 Male, age 18, unknown 96.1
Substantia nigra
nTPM: 131.0
2699 Male, age 18, unknown 158.8
1916 Female, age 42, unknown 146.0
2241 Male, age 72, unknown 139.8
1889 Female, age 72, unknown 138.1
1851 Male, age 51, unknown 136.5
2409 Female, age 72, unknown 123.7
2583 Male, age 75, right hemisphere 122.3
2590 Female, age 75, unknown 120.9
1941 Male, age 53, unknown 113.2
2665 Male, age 74, both hemispheres 111.0
Superior colliculus
nTPM: 125.5
1995 Male, age 72, unknown 132.1
2087 Female, age 72, unknown 131.0
1839 Male, age 51, unknown 130.0
2664 Male, age 75, both hemispheres 129.7
1796 Male, age 53, unknown 128.8
2668 Female, age 75, unknown 128.5
2261 Male, age 18, unknown 120.7
1913 Female, age 42, unknown 119.2
1895 Male, age 76, right hemisphere 117.9
2587 Male, age 74, left hemisphere 116.7
Ventral tegmental area
nTPM: 129.3
1915 Female, age 42, unknown 148.1
1942 Male, age 51, unknown 135.8
2410 Female, age 72, unknown 133.1
2021 Male, age 53, unknown 123.6
2218 Male, age 76, both hemispheres 120.3
2223 Female, age 72, unknown 114.9

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 142.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 142.8
Samples: 139

Max nTPM: 397.6
Min nTPM: 14.6
Std nTPM: 78.8
Median nTPM: 132.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 397.6
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 392.0
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 365.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 358.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 355.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 349.7
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 326.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 316.5
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 315.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 270.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 267.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 246.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 244.3
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 238.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 235.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 232.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 228.4
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 224.7
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 224.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 221.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 219.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 218.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 217.1
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 216.4
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 212.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 204.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 201.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 201.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 200.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 196.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 193.3
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 187.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 180.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 179.1
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 178.6
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 177.8
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 171.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 167.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 167.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 165.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 164.4
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 164.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 162.9
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 158.1
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 157.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 156.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 156.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 155.8
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 153.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 152.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 152.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 150.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 149.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 147.3
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 147.0
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 145.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 144.3
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 142.8
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 141.2
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 139.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 138.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 138.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 138.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 137.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 136.8
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 136.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 136.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 135.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 133.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 132.7
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 132.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 132.1
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 129.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 129.2
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 124.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 120.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 116.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 116.1
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 115.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 114.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 114.1
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 112.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 110.9
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 108.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 106.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 106.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 105.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 105.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 102.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 101.1
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 100.9
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 99.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 98.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 98.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 97.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 95.9
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 91.3
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 90.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 90.6
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 89.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 87.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 87.2
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 86.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 85.9
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 85.3
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 85.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 84.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 83.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 81.8
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 81.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 81.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 78.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 77.0
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 76.6
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 76.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 76.0
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 74.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 73.7
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 72.1
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 68.3
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 66.6
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 65.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 63.7
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 63.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 62.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 57.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 55.4
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 54.8
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 53.2
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 50.2
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 46.7
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 45.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 41.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 40.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 38.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 34.7
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 29.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 28.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 14.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 115.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 115.0
FF:10158-103A5 76 years, female 115.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 63.4
Pig sample Sample description nTPM
Midbrain
nTPM: 63.4
Samples: 4

Max nTPM: 75.9
Min nTPM: 52.5
Sample A Female 58.0
Sample B Female 52.5
Sample C Male 75.9
Sample D Male 67.1
Periaqueductal gray
nTPM: 46.1
Samples: 3

Max nTPM: 53.1
Min nTPM: 37.7
Sample B Female 53.1
Sample C Male 47.6
Sample D Male 37.7
Substantia nigra
nTPM: 58.2
Samples: 4

Max nTPM: 62.4
Min nTPM: 50.2
Sample A Female 62.4
Sample B Female 50.2
Sample C Male 59.8
Sample D Male 60.3
Superior colliculi
nTPM: 63.2
Samples: 4

Max nTPM: 68.6
Min nTPM: 52.3
Sample A Female 68.4
Sample B Female 68.6
Sample C Male 52.3
Sample D Male 63.6

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 418.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 418.5
Samples: 4

Max nTPM: 440.4
Min nTPM: 408.1
Sample A Male 440.4
Sample B Male 408.1
Sample C Female 409.3
Sample D Female 416.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 10.8
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 10.8
70429429 Antisense, RP_050614_01_F06, Mouse strain C57BL/6J (56 days, male) 11.8
74047768 Antisense, RP_051214_01_H06, Mouse strain C57BL/6J (56 days, male) 9.9

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