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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:159.0 nTPM
HPA:159.0 nTPM
GTEx:133.1 nTPM
FANTOM5:131.8 Scaled Tags Per Million
Pig:79.8 nTPM
Mouse:106.3 nTPM
Allen mouse:8.3 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 159.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 105.8
2219 Male, age 76, both hemispheres 122.3
2586 Male, age 75, left hemisphere 112.7
2828 Female, age 72, unknown 109.9
1827 Male, age 72, unknown 108.8
2019 Male, age 18, unknown 108.8
1870 Female, age 42, unknown 104.4
2411 Female, age 72, unknown 102.9
1833 Male, age 53, unknown 99.7
1830 Male, age 51, unknown 94.2
2666 Male, age 74, left hemisphere 93.9
Dorsal raphe nucleus
nTPM: 107.2
2298 Female, age 72, unknown 110.9
2750 Male, age 76, both hemispheres 109.0
1828 Male, age 53, unknown 107.8
2047 Male, age 72, unknown 104.8
2016 Female, age 72, unknown 103.5
Inferior colliculus
nTPM: 102.2
1890 Male, age 53, unknown 114.6
2097 Female, age 72, unknown 104.0
1848 Female, age 42, unknown 95.6
2849 Male, age 72, unknown 94.6
Median raphe nucleus
nTPM: 107.5
2220 Male, age 76, midline 107.5
Pedunculopontine tegmental nucleus
nTPM: 95.5
2334 Male, age 80, both hemispheres 104.4
1921 Female, age 85, both hemispheres 99.4
2338 Male, age 61, both hemispheres 82.5
Periaquaductal grey, anterior
nTPM: 91.2
2502 Female, age 75, unknown 108.3
1795 Male, age 51, unknown 91.2
1947 Male, age 18, unknown 74.2
Periaquaductal grey, dorsal
nTPM: 98.2
1840 Male, age 53, unknown 108.1
1831 Male, age 72, unknown 98.9
2464 Female, age 72, unknown 93.8
2850 Male, age 76, both hemispheres 92.0
Periaquaductal grey, lateral
nTPM: 92.0
2053 Male, age 18, unknown 97.9
2140 Male, age 76, both hemispheres 92.7
2272 Male, age 74, both hemispheres 85.3
Pretectal area
nTPM: 105.9
1944 Female, age 72, unknown 120.3
1816 Male, age 51, unknown 115.2
2667 Female, age 75, unknown 113.2
1815 Male, age 53, unknown 112.6
2007 Male, age 72, unknown 109.9
1817 Female, age 42, unknown 103.2
2407 Male, age 75, both hemispheres 100.7
2224 Female, age 72, unknown 100.3
2825 Male, age 18, unknown 100.0
2273 Male, age 74, both hemispheres 97.5
2316 Male, age 76, right hemisphere 92.6
Red nucleus
nTPM: 102.1
1821 Female, age 72, unknown 119.6
2588 Male, age 74, left hemisphere 106.7
2785 Male, age 18, unknown 106.2
2503 Female, age 72, unknown 105.2
2584 Male, age 75, left hemisphere 101.9
2227 Male, age 72, unknown 101.5
1904 Male, age 53, unknown 99.8
1865 Male, age 51, unknown 99.2
2769 Male, age 72, unknown 99.1
1954 Female, age 42, unknown 96.9
2823 Male, age 76, right hemisphere 96.5
2725 Female, age 75, unknown 92.4
Substantia nigra
nTPM: 159.0
1916 Female, age 42, unknown 239.4
1851 Male, age 51, unknown 188.9
2241 Male, age 72, unknown 180.4
2699 Male, age 18, unknown 178.0
2409 Female, age 72, unknown 146.3
1941 Male, age 53, unknown 143.3
2665 Male, age 74, both hemispheres 138.4
2583 Male, age 75, right hemisphere 128.3
2590 Female, age 75, unknown 124.1
1889 Female, age 72, unknown 123.2
Superior colliculus
nTPM: 102.4
2087 Female, age 72, unknown 113.7
1796 Male, age 53, unknown 109.7
2668 Female, age 75, unknown 107.7
2587 Male, age 74, left hemisphere 106.4
2664 Male, age 75, both hemispheres 102.9
2261 Male, age 18, unknown 101.2
1895 Male, age 76, right hemisphere 98.0
1839 Male, age 51, unknown 97.2
1913 Female, age 42, unknown 94.5
1995 Male, age 72, unknown 93.1
Ventral tegmental area
nTPM: 134.8
1915 Female, age 42, unknown 161.2
2410 Female, age 72, unknown 150.6
2218 Male, age 76, both hemispheres 142.7
2223 Female, age 72, unknown 125.2
1942 Male, age 51, unknown 120.9
2021 Male, age 53, unknown 108.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 133.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 133.1
Samples: 139

Max nTPM: 234.0
Min nTPM: 73.0
Std nTPM: 27.6
Median nTPM: 131.4
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 234.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 205.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 203.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 199.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 190.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 185.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 184.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 182.1
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 178.2
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 178.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 176.7
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 174.6
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 170.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 170.0
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 169.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 167.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 167.5
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 164.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 164.7
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 163.2
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 162.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 160.9
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 157.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 156.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 156.3
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 155.2
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 155.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 154.6
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 154.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 154.4
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 154.2
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 153.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 152.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 152.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 149.9
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 148.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 147.6
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 147.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 146.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 145.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 145.6
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 145.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 144.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 143.9
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 143.9
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 143.0
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 139.1
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 138.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 138.6
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 138.3
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 138.3
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 137.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 137.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 136.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 136.2
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 135.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 134.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 134.0
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 133.7
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 133.5
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 133.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 133.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 133.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 132.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 132.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 132.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 132.0
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 132.0
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 131.5
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 131.4
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 131.2
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 131.1
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 130.6
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 130.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 129.3
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 127.3
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 127.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 126.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 126.2
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 126.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 124.9
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 124.8
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 123.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 121.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 120.9
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 120.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 120.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 120.4
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 119.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 119.5
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 119.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 119.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 119.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 118.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 118.2
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 117.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 117.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 117.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 117.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 116.7
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 116.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 115.8
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 115.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 115.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 115.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 115.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 114.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 114.3
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 114.2
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 113.0
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 111.6
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 109.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 109.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 109.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 108.3
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 107.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 107.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 106.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 106.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 104.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 103.7
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 103.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 101.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 100.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 99.7
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 99.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 99.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 99.2
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 96.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 95.6
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 93.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 93.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 92.9
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 92.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 91.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 87.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 82.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 80.1
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 73.0
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 131.8
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 131.8
FF:10158-103A5 76 years, female 131.8

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 79.8
Pig sample Sample description nTPM
Midbrain
nTPM: 79.8
Samples: 4

Max nTPM: 91.8
Min nTPM: 60.0
Sample A Female 90.1
Sample B Female 60.0
Sample C Male 91.8
Sample D Male 77.2
Periaqueductal gray
nTPM: 52.7
Samples: 3

Max nTPM: 58.1
Min nTPM: 46.5
Sample B Female 53.5
Sample C Male 58.1
Sample D Male 46.5
Substantia nigra
nTPM: 71.8
Samples: 4

Max nTPM: 89.9
Min nTPM: 49.5
Sample A Female 89.5
Sample B Female 49.5
Sample C Male 89.9
Sample D Male 58.1
Superior colliculi
nTPM: 74.3
Samples: 4

Max nTPM: 94.5
Min nTPM: 49.5
Sample A Female 75.0
Sample B Female 49.5
Sample C Male 94.5
Sample D Male 78.3

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 106.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 106.3
Samples: 4

Max nTPM: 115.2
Min nTPM: 97.4
Sample A Male 97.4
Sample B Male 105.3
Sample C Female 115.2
Sample D Female 107.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 8.3
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 8.3
74357551 Antisense, RP_051214_01_B03, Mouse strain C57BL/6J (56 days, male) 10.4
68795416 Antisense, RP_041122_01_C04, Mouse strain C57BL/6J (56 days, male) 6.3

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