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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:271.1 nTPM
HPA:271.1 nTPM
GTEx:161.8 nTPM
FANTOM5:475.8 Scaled Tags Per Million
Pig:110.4 nTPM
Mouse:85.6 nTPM
Allen mouse:15.6 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 271.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 202.6
1830 Male, age 51, unknown 260.8
1833 Male, age 53, unknown 251.8
2411 Female, age 72, unknown 238.9
1870 Female, age 42, unknown 233.1
2019 Male, age 18, unknown 230.3
2666 Male, age 74, left hemisphere 203.3
2828 Female, age 72, unknown 180.5
2586 Male, age 75, left hemisphere 143.3
1827 Male, age 72, unknown 143.2
2219 Male, age 76, both hemispheres 140.6
Dorsal raphe nucleus
nTPM: 144.3
2750 Male, age 76, both hemispheres 242.6
2016 Female, age 72, unknown 153.1
1828 Male, age 53, unknown 141.3
2047 Male, age 72, unknown 95.4
2298 Female, age 72, unknown 89.0
Inferior colliculus
nTPM: 139.1
1848 Female, age 42, unknown 148.2
1890 Male, age 53, unknown 146.6
2849 Male, age 72, unknown 136.7
2097 Female, age 72, unknown 125.0
Median raphe nucleus
nTPM: 130.0
2220 Male, age 76, midline 130.0
Pedunculopontine tegmental nucleus
nTPM: 187.5
2338 Male, age 61, both hemispheres 208.3
2334 Male, age 80, both hemispheres 196.4
1921 Female, age 85, both hemispheres 157.8
Periaquaductal grey, anterior
nTPM: 123.8
2502 Female, age 75, unknown 149.6
1947 Male, age 18, unknown 128.8
1795 Male, age 51, unknown 92.8
Periaquaductal grey, dorsal
nTPM: 107.6
2464 Female, age 72, unknown 157.5
1831 Male, age 72, unknown 111.5
2850 Male, age 76, both hemispheres 82.8
1840 Male, age 53, unknown 78.7
Periaquaductal grey, lateral
nTPM: 102.0
2053 Male, age 18, unknown 123.3
2272 Male, age 74, both hemispheres 106.3
2140 Male, age 76, both hemispheres 76.3
Pretectal area
nTPM: 132.7
1815 Male, age 53, unknown 183.4
2316 Male, age 76, right hemisphere 178.1
1817 Female, age 42, unknown 160.0
2407 Male, age 75, both hemispheres 144.8
2007 Male, age 72, unknown 144.3
2825 Male, age 18, unknown 132.1
1944 Female, age 72, unknown 108.7
2224 Female, age 72, unknown 106.5
2273 Male, age 74, both hemispheres 102.8
2667 Female, age 75, unknown 99.6
1816 Male, age 51, unknown 99.5
Red nucleus
nTPM: 271.1
1865 Male, age 51, unknown 344.7
1904 Male, age 53, unknown 319.0
1821 Female, age 72, unknown 315.9
2823 Male, age 76, right hemisphere 294.6
2503 Female, age 72, unknown 284.2
2227 Male, age 72, unknown 270.5
2769 Male, age 72, unknown 264.2
1954 Female, age 42, unknown 262.9
2785 Male, age 18, unknown 246.7
2588 Male, age 74, left hemisphere 239.8
2725 Female, age 75, unknown 231.1
2584 Male, age 75, left hemisphere 179.7
Substantia nigra
nTPM: 163.9
2409 Female, age 72, unknown 207.3
2241 Male, age 72, unknown 184.2
1889 Female, age 72, unknown 178.7
1851 Male, age 51, unknown 178.4
2590 Female, age 75, unknown 173.7
2583 Male, age 75, right hemisphere 158.1
2699 Male, age 18, unknown 150.9
2665 Male, age 74, both hemispheres 150.2
1941 Male, age 53, unknown 137.2
1916 Female, age 42, unknown 120.7
Superior colliculus
nTPM: 173.4
1995 Male, age 72, unknown 239.3
1913 Female, age 42, unknown 234.6
1895 Male, age 76, right hemisphere 221.4
2587 Male, age 74, left hemisphere 188.9
2668 Female, age 75, unknown 188.4
1839 Male, age 51, unknown 175.8
1796 Male, age 53, unknown 132.1
2087 Female, age 72, unknown 124.7
2261 Male, age 18, unknown 121.6
2664 Male, age 75, both hemispheres 107.4
Ventral tegmental area
nTPM: 168.7
2223 Female, age 72, unknown 232.3
2410 Female, age 72, unknown 216.7
1915 Female, age 42, unknown 146.6
1942 Male, age 51, unknown 145.9
2021 Male, age 53, unknown 136.5
2218 Male, age 76, both hemispheres 134.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 161.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 161.8
Samples: 139

Max nTPM: 457.0
Min nTPM: 54.5
Std nTPM: 83.1
Median nTPM: 134.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 457.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 428.2
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 418.1
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 385.1
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 369.8
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 365.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 363.8
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 341.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 340.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 311.5
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 308.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 296.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 291.0
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 281.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 280.9
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 266.6
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 264.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 245.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 243.6
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 238.9
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 233.1
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 232.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 232.1
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 228.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 224.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 223.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 221.7
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 221.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 218.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 215.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 213.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 212.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 212.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 209.3
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 205.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 202.4
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 196.7
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 192.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 192.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 192.5
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 191.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 189.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 188.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 186.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 178.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 177.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 170.5
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 169.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 167.8
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 162.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 162.4
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 161.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 160.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 160.1
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 158.3
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 154.4
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 152.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 150.3
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 149.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 147.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 147.3
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 145.7
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 143.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 139.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 138.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 137.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 136.9
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 135.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 135.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 134.9
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 132.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 132.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 131.8
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 128.0
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 126.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 126.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 124.7
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 124.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 124.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 123.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 123.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 122.9
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 122.4
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 121.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 121.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 120.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 119.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 118.3
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 117.9
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 117.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 117.2
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 117.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 115.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 115.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 112.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 112.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 110.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 109.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 109.4
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 107.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 106.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 105.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 105.0
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 104.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 104.2
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 98.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 97.7
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 97.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 96.9
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 96.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 94.3
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 93.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 93.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 93.2
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 93.0
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 92.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 92.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 92.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 91.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 90.9
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 90.0
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 89.3
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 89.0
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 87.9
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 84.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 84.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 81.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 80.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 80.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 79.1
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 69.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 69.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 69.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 68.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 66.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 62.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 62.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 58.5
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 54.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 475.8
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 475.8
FF:10158-103A5 76 years, female 475.8

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 110.4
Pig sample Sample description nTPM
Midbrain
nTPM: 110.4
Samples: 4

Max nTPM: 193.2
Min nTPM: 60.0
Sample A Female 193.2
Sample B Female 117.6
Sample C Male 60.0
Sample D Male 70.8
Periaqueductal gray
nTPM: 80.9
Samples: 3

Max nTPM: 97.2
Min nTPM: 56.3
Sample B Female 97.2
Sample C Male 56.3
Sample D Male 89.2
Substantia nigra
nTPM: 108.0
Samples: 4

Max nTPM: 188.4
Min nTPM: 66.7
Sample A Female 92.9
Sample B Female 66.7
Sample C Male 83.8
Sample D Male 188.4
Superior colliculi
nTPM: 82.1
Samples: 4

Max nTPM: 110.6
Min nTPM: 44.5
Sample A Female 83.8
Sample B Female 44.5
Sample C Male 89.5
Sample D Male 110.6

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 85.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 85.6
Samples: 4

Max nTPM: 88.4
Min nTPM: 83.3
Sample A Male 83.3
Sample B Male 86.7
Sample C Female 88.4
Sample D Female 84.0

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 15.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 15.6
68080699 Antisense, RP_040929_01_F07, Mouse strain C57BL/6J (56 days, male) 15.6

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