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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:402.7 nTPM
HPA:402.7 nTPM
GTEx:450.1 nTPM
FANTOM5:455.7 Scaled Tags Per Million
Pig:61.4 nTPM
Mouse:203.0 nTPM
Allen mouse:3.2 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 402.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 304.2
2219 Male, age 76, both hemispheres 332.8
1870 Female, age 42, unknown 316.5
1833 Male, age 53, unknown 309.5
2019 Male, age 18, unknown 302.1
1827 Male, age 72, unknown 301.9
1830 Male, age 51, unknown 300.6
2666 Male, age 74, left hemisphere 299.7
2828 Female, age 72, unknown 297.8
2411 Female, age 72, unknown 297.0
2586 Male, age 75, left hemisphere 284.0
Dorsal raphe nucleus
nTPM: 316.3
2750 Male, age 76, both hemispheres 332.8
2047 Male, age 72, unknown 318.5
2298 Female, age 72, unknown 313.3
1828 Male, age 53, unknown 309.7
2016 Female, age 72, unknown 307.3
Inferior colliculus
nTPM: 311.1
2849 Male, age 72, unknown 323.4
1890 Male, age 53, unknown 310.0
1848 Female, age 42, unknown 308.5
2097 Female, age 72, unknown 302.6
Median raphe nucleus
nTPM: 402.7
2220 Male, age 76, midline 402.7
Pedunculopontine tegmental nucleus
nTPM: 344.1
2338 Male, age 61, both hemispheres 377.6
2334 Male, age 80, both hemispheres 336.3
1921 Female, age 85, both hemispheres 318.5
Periaquaductal grey, anterior
nTPM: 309.2
2502 Female, age 75, unknown 311.3
1947 Male, age 18, unknown 310.8
1795 Male, age 51, unknown 305.5
Periaquaductal grey, dorsal
nTPM: 316.0
2850 Male, age 76, both hemispheres 363.9
1840 Male, age 53, unknown 304.5
1831 Male, age 72, unknown 301.3
2464 Female, age 72, unknown 294.3
Periaquaductal grey, lateral
nTPM: 314.5
2140 Male, age 76, both hemispheres 330.4
2272 Male, age 74, both hemispheres 308.3
2053 Male, age 18, unknown 304.6
Pretectal area
nTPM: 316.1
2667 Female, age 75, unknown 335.7
2407 Male, age 75, both hemispheres 319.9
2273 Male, age 74, both hemispheres 319.7
1816 Male, age 51, unknown 316.7
1817 Female, age 42, unknown 316.6
2224 Female, age 72, unknown 315.0
1815 Male, age 53, unknown 314.9
1944 Female, age 72, unknown 312.6
2316 Male, age 76, right hemisphere 309.9
2825 Male, age 18, unknown 309.3
2007 Male, age 72, unknown 306.7
Red nucleus
nTPM: 312.7
1821 Female, age 72, unknown 329.0
1865 Male, age 51, unknown 326.8
1954 Female, age 42, unknown 322.3
2725 Female, age 75, unknown 319.4
2503 Female, age 72, unknown 318.6
1904 Male, age 53, unknown 318.4
2823 Male, age 76, right hemisphere 315.6
2227 Male, age 72, unknown 310.2
2769 Male, age 72, unknown 308.0
2785 Male, age 18, unknown 307.6
2584 Male, age 75, left hemisphere 289.1
2588 Male, age 74, left hemisphere 287.5
Substantia nigra
nTPM: 321.3
2699 Male, age 18, unknown 351.7
1916 Female, age 42, unknown 345.8
2241 Male, age 72, unknown 342.4
1851 Male, age 51, unknown 325.0
1941 Male, age 53, unknown 321.6
1889 Female, age 72, unknown 318.2
2409 Female, age 72, unknown 315.2
2665 Male, age 74, both hemispheres 305.2
2590 Female, age 75, unknown 298.1
2583 Male, age 75, right hemisphere 290.2
Superior colliculus
nTPM: 306.0
1895 Male, age 76, right hemisphere 315.8
1796 Male, age 53, unknown 312.9
2587 Male, age 74, left hemisphere 312.0
1913 Female, age 42, unknown 311.9
2087 Female, age 72, unknown 305.5
2668 Female, age 75, unknown 301.9
1839 Male, age 51, unknown 300.9
2261 Male, age 18, unknown 300.7
1995 Male, age 72, unknown 299.4
2664 Male, age 75, both hemispheres 299.4
Ventral tegmental area
nTPM: 324.8
2218 Male, age 76, both hemispheres 349.6
2223 Female, age 72, unknown 335.7
1915 Female, age 42, unknown 332.8
1942 Male, age 51, unknown 313.7
2021 Male, age 53, unknown 312.0
2410 Female, age 72, unknown 305.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 450.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 450.1
Samples: 139

Max nTPM: 1314.4
Min nTPM: 264.0
Std nTPM: 114.2
Median nTPM: 436.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1314.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 933.9
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 629.2
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 627.6
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 624.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 624.2
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 622.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 609.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 595.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 592.4
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 591.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 567.8
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 561.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 559.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 551.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 547.2
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 540.6
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 539.2
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 521.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 518.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 516.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 513.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 513.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 511.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 509.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 508.7
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 505.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 505.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 505.5
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 497.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 494.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 493.4
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 493.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 493.2
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 489.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 487.8
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 483.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 483.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 482.9
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 478.8
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 477.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 476.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 474.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 473.9
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 470.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 469.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 469.8
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 467.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 467.5
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 466.9
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 465.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 461.7
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 460.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 457.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 456.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 455.3
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 451.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 451.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 450.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 449.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 447.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 445.8
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 445.4
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 442.5
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 441.7
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 438.9
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 437.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 437.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 437.0
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 436.9
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 435.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 434.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 434.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 431.8
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 431.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 430.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 428.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 427.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 426.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 425.3
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 423.0
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 422.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 421.6
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 418.7
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 417.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 416.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 413.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 410.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 410.7
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 410.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 409.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 409.0
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 408.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 403.4
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 403.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 400.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 400.3
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 396.8
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 396.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 394.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 394.1
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 393.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 392.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 391.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 387.0
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 385.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 385.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 380.8
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 380.4
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 380.3
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 380.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 379.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 368.2
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 367.2
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 366.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 365.8
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 365.4
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 364.8
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 363.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 357.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 355.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 354.5
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 354.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 352.9
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 352.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 349.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 348.7
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 346.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 337.0
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 337.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 333.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 315.3
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 314.4
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 311.4
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 308.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 303.3
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 289.0
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 268.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 264.0
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 455.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 455.7
FF:10158-103A5 76 years, female 455.7

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 61.4
Pig sample Sample description nTPM
Midbrain
nTPM: 59.5
Samples: 4

Max nTPM: 67.2
Min nTPM: 53.7
Sample A Female 67.2
Sample B Female 60.7
Sample C Male 53.7
Sample D Male 56.3
Periaqueductal gray
nTPM: 53.0
Samples: 3

Max nTPM: 55.9
Min nTPM: 49.5
Sample B Female 53.7
Sample C Male 55.9
Sample D Male 49.5
Substantia nigra
nTPM: 58.1
Samples: 4

Max nTPM: 78.8
Min nTPM: 45.6
Sample A Female 78.8
Sample B Female 45.6
Sample C Male 60.0
Sample D Male 47.9
Superior colliculi
nTPM: 61.4
Samples: 4

Max nTPM: 78.4
Min nTPM: 44.1
Sample A Female 78.4
Sample B Female 44.1
Sample C Male 64.8
Sample D Male 58.4

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 203.0
Mouse sample Sample description nTPM
Midbrain
nTPM: 203.0
Samples: 4

Max nTPM: 219.8
Min nTPM: 192.1
Sample A Male 219.8
Sample B Male 192.1
Sample C Female 196.2
Sample D Female 203.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 3.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 3.2
74750021 Antisense, RP_060220_05_E11, Mouse strain C57BL/6J (56 days, male) 4.1
70439183 Antisense, RP_050614_03_D02, Mouse strain C57BL/6J (56 days, male) 2.3

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