Single cell type - PLA2G7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLA2G7
Gene descriptionⁱ Full gene name according to HGNC.	Phospholipase A2 group VII
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Candidate cardiovascular disease genes Disease related genes Enzymes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells, Macrophages, Prostatic glandular cells, Endometrial stromal cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type. Read more	0.87
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (classical monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells, Macrophages, Prostatic glandular cells, Endometrial stromal cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Salivary gland Skeletal muscle Skin Small intestine Spleen Stomach Testis Thymus Tongue Vascular

EXPRESSION CLUSTERING & CORRELATIONⁱ

PLA2G7 is part of cluster 69 Macrophages - Innate immune response with confidenceⁱ 1
217 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RAB42	RAB42, member RAS oncogene family	0.8762	69
TM4SF19	Transmembrane 4 L six family member 19	0.8689	69
CCL7	C-C motif chemokine ligand 7	0.8547	69
TREM2	Triggering receptor expressed on myeloid cells 2	0.8533	69
CTSB	Cathepsin B	0.8471	69
ADAMDEC1	ADAM like decysin 1	0.8325	69
OTOA	Otoancorin	0.8305	69
CRYBB1	Crystallin beta B1	0.8179	69
C1QC	Complement C1q C chain	0.8150	69
LIPA	Lipase A, lysosomal acid type	0.7954	69
LAIR1	Leukocyte associated immunoglobulin like receptor 1	0.7904	69
SIGLEC9	Sialic acid binding Ig like lectin 9	0.7880	69
MS4A4A	Membrane spanning 4-domains A4A	0.7876	69
C1QB	Complement C1q B chain	0.7805	69
SIGLEC1	Sialic acid binding Ig like lectin 1	0.7728	69

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Salivary gland
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis
Cluster Expression Alphabetical Thymus
Cluster Expression Alphabetical Tongue
Cluster Expression Alphabetical Vascular

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

Adipocytes	0.5 nTPM
Breast	0.8 nTPM
Adipose tissue	0.2 nTPM

Alveolar cells type 1	0.4 nTPM
Lung	0.4 nTPM

Alveolar cells type 2	5.2 nTPM
Lung	5.2 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	0.2 nTPM
Lung	2.7 nTPM
Spleen	0.2 nTPM
Lymph node	0.1 nTPM
Salivary gland	0.1 nTPM
Thymus	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Club cells	3.7 nTPM
Prostate	6.0 nTPM
Lung	5.1 nTPM
Bronchus	0.0 nTPM

Endothelial cells	0.8 nTPM
Placenta	2.9 nTPM
Endometrium	2.6 nTPM
Pancreas	2.6 nTPM
Lung	1.4 nTPM
Liver	1.3 nTPM
Prostate	1.0 nTPM
Vascular	1.0 nTPM
Esophagus	0.5 nTPM
Thymus	0.4 nTPM
Tongue	0.4 nTPM
Ovary	0.1 nTPM
Testis	0.0 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Salivary gland	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	1.3 nTPM
Ovary	2.9 nTPM
Salivary gland	2.0 nTPM
Thymus	2.0 nTPM
Breast	1.9 nTPM
Lung	1.8 nTPM
Placenta	1.7 nTPM
Adipose tissue	1.7 nTPM
Vascular	1.7 nTPM
Stomach	1.5 nTPM
Prostate	1.3 nTPM
Esophagus	1.2 nTPM
Skeletal muscle	1.1 nTPM
Skin	0.4 nTPM
Pancreas	0.2 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM

Intestinal goblet cells	0.2 nTPM
Rectum	0.5 nTPM
Colon	0.2 nTPM
Small intestine	0.0 nTPM

Macrophages	103.3 nTPM
Pancreas	725.5 nTPM
Ovary	616.0 nTPM
Thymus	92.3 nTPM
Spleen	88.5 nTPM
Kidney	76.0 nTPM
Prostate	75.1 nTPM
Lung	69.0 nTPM
Bone marrow	50.3 nTPM
Stomach	49.6 nTPM
Endometrium	49.0 nTPM
Breast	47.7 nTPM
Vascular	42.7 nTPM
Salivary gland	41.3 nTPM
Liver	38.7 nTPM
PBMC	38.4 nTPM
Skeletal muscle	21.9 nTPM
Adipose tissue	18.6 nTPM
Skin	14.7 nTPM
Tongue	10.6 nTPM
Testis	1.3 nTPM
Esophagus	1.3 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	0.2 nTPM
Liver	1.0 nTPM
Salivary gland	0.5 nTPM
Thymus	0.1 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	0.4 nTPM
Lung	0.5 nTPM
Bronchus	0.2 nTPM

Schwann cells	0.3 nTPM
Vascular	0.5 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Excitatory neurons	7.1 nTPM
Brain	7.1 nTPM

Extravillous trophoblasts	5.6 nTPM
Placenta	5.6 nTPM

Serous glandular cells	0.5 nTPM
Salivary gland	0.9 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.7 nTPM
Placenta	31.8 nTPM
Endometrium	5.2 nTPM
Lung	3.6 nTPM
Heart muscle	2.1 nTPM
Salivary gland	0.8 nTPM
Thymus	0.6 nTPM
Ovary	0.5 nTPM
Breast	0.5 nTPM
Vascular	0.3 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM
Tongue	0.0 nTPM

T-cells	0.7 nTPM
Endometrium	5.4 nTPM
Lung	2.1 nTPM
Colon	2.0 nTPM
Placenta	1.6 nTPM
Liver	1.3 nTPM
Kidney	0.9 nTPM
PBMC	0.9 nTPM
Thymus	0.3 nTPM
Spleen	0.2 nTPM
Breast	0.2 nTPM
Stomach	0.1 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM

Undifferentiated cells	0.3 nTPM
Colon	0.6 nTPM
Rectum	0.2 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Salivary gland

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

Thymus

Tongue

Vascular

PBMC