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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:2572.6 nTPM
HPA:2572.6 nTPM
GTEx:3573.3 nTPM
FANTOM5:22.9 Scaled Tags Per Million
Pig:1903.8 nTPM
Mouse:2766.5 nTPM
Allen mouse:26.6 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 2572.6
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 2458.0
2411 Female, age 72, unknown 2661.5
1870 Female, age 42, unknown 2570.3
2828 Female, age 72, unknown 2531.6
2586 Male, age 75, left hemisphere 2522.2
2666 Male, age 74, left hemisphere 2440.0
1830 Male, age 51, unknown 2435.6
1833 Male, age 53, unknown 2424.6
1827 Male, age 72, unknown 2410.8
2019 Male, age 18, unknown 2407.1
2219 Male, age 76, both hemispheres 2176.7
Dorsal raphe nucleus
nTPM: 2519.5
2016 Female, age 72, unknown 2651.6
2298 Female, age 72, unknown 2632.7
2750 Male, age 76, both hemispheres 2456.6
1828 Male, age 53, unknown 2451.3
2047 Male, age 72, unknown 2405.5
Inferior colliculus
nTPM: 2468.6
2097 Female, age 72, unknown 2533.5
1890 Male, age 53, unknown 2514.6
1848 Female, age 42, unknown 2474.8
2849 Male, age 72, unknown 2351.6
Median raphe nucleus
nTPM: 2349.6
2220 Male, age 76, midline 2349.6
Pedunculopontine tegmental nucleus
nTPM: 2424.7
2338 Male, age 61, both hemispheres 2510.0
2334 Male, age 80, both hemispheres 2509.5
1921 Female, age 85, both hemispheres 2254.7
Periaquaductal grey, anterior
nTPM: 2565.0
2502 Female, age 75, unknown 2788.4
1795 Male, age 51, unknown 2482.3
1947 Male, age 18, unknown 2424.4
Periaquaductal grey, dorsal
nTPM: 2509.4
1840 Male, age 53, unknown 2599.9
1831 Male, age 72, unknown 2552.9
2464 Female, age 72, unknown 2540.9
2850 Male, age 76, both hemispheres 2343.9
Periaquaductal grey, lateral
nTPM: 2497.0
2053 Male, age 18, unknown 2635.4
2140 Male, age 76, both hemispheres 2439.2
2272 Male, age 74, both hemispheres 2416.5
Pretectal area
nTPM: 2386.1
2316 Male, age 76, right hemisphere 2538.7
2825 Male, age 18, unknown 2512.0
2407 Male, age 75, both hemispheres 2503.2
2224 Female, age 72, unknown 2482.8
2273 Male, age 74, both hemispheres 2416.8
1815 Male, age 53, unknown 2389.0
2667 Female, age 75, unknown 2358.7
2007 Male, age 72, unknown 2293.7
1817 Female, age 42, unknown 2289.4
1816 Male, age 51, unknown 2244.1
1944 Female, age 72, unknown 2218.8
Red nucleus
nTPM: 2572.6
2503 Female, age 72, unknown 2886.0
1865 Male, age 51, unknown 2680.8
2227 Male, age 72, unknown 2669.3
2769 Male, age 72, unknown 2662.5
1821 Female, age 72, unknown 2622.4
1904 Male, age 53, unknown 2603.3
2584 Male, age 75, left hemisphere 2522.1
2785 Male, age 18, unknown 2473.3
1954 Female, age 42, unknown 2468.6
2588 Male, age 74, left hemisphere 2451.9
2823 Male, age 76, right hemisphere 2425.5
2725 Female, age 75, unknown 2405.9
Substantia nigra
nTPM: 2459.6
1851 Male, age 51, unknown 2624.6
2590 Female, age 75, unknown 2603.2
2665 Male, age 74, both hemispheres 2576.0
2699 Male, age 18, unknown 2536.6
2583 Male, age 75, right hemisphere 2460.7
2409 Female, age 72, unknown 2449.5
2241 Male, age 72, unknown 2419.6
1916 Female, age 42, unknown 2342.9
1941 Male, age 53, unknown 2294.6
1889 Female, age 72, unknown 2288.6
Superior colliculus
nTPM: 2494.8
1995 Male, age 72, unknown 2692.3
2587 Male, age 74, left hemisphere 2684.1
2664 Male, age 75, both hemispheres 2644.2
1913 Female, age 42, unknown 2589.5
1839 Male, age 51, unknown 2491.5
1796 Male, age 53, unknown 2466.1
2261 Male, age 18, unknown 2390.8
2087 Female, age 72, unknown 2343.3
2668 Female, age 75, unknown 2337.8
1895 Male, age 76, right hemisphere 2308.6
Ventral tegmental area
nTPM: 2543.4
2021 Male, age 53, unknown 2650.6
2410 Female, age 72, unknown 2633.9
2223 Female, age 72, unknown 2567.3
1915 Female, age 42, unknown 2528.5
1942 Male, age 51, unknown 2513.2
2218 Male, age 76, both hemispheres 2367.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 3573.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 3573.3
Samples: 139

Max nTPM: 6481.4
Min nTPM: 1292.9
Std nTPM: 1058.9
Median nTPM: 3463.1
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 6481.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 6286.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 6112.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 6092.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 5846.9
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 5617.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 5610.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 5539.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 5294.4
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 5177.2
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 5112.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 5021.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 4962.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 4869.7
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 4852.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 4852.8
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 4827.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 4826.9
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 4721.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 4694.3
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 4679.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 4665.0
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 4664.8
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 4647.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 4642.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 4636.6
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 4601.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 4532.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 4501.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 4473.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 4470.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 4440.7
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 4370.9
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 4325.3
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 4300.9
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 4291.7
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 4249.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 4216.3
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 4211.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 4197.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 4171.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 4166.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 4160.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 4130.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 4121.9
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 4116.5
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 4007.0
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 3993.4
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 3989.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 3935.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 3924.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 3913.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 3886.1
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 3875.7
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 3862.2
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 3853.4
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 3852.2
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 3840.8
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 3814.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 3766.3
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 3759.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 3731.9
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 3643.3
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 3623.4
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 3589.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 3553.8
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 3548.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 3529.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 3516.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 3463.1
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 3426.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 3424.5
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 3410.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 3356.0
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 3312.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 3250.4
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 3234.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 3218.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 3216.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 3216.1
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 3196.9
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 3167.2
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 3145.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 3131.2
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 3069.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 3050.4
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 3026.4
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 3012.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 3000.0
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 2970.8
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 2961.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 2934.5
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 2923.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 2914.6
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 2860.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 2826.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 2791.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 2791.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 2773.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 2765.9
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 2759.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 2758.2
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 2752.2
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 2752.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 2745.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 2712.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 2703.4
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 2701.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 2700.1
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 2692.9
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 2669.6
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 2660.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 2599.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 2583.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 2575.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 2526.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 2525.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 2487.9
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 2471.7
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 2377.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 2352.8
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 2343.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 2299.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 2295.4
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 2281.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 2279.2
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 2267.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 2205.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 2199.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 2196.4
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 2187.6
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 2187.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 2152.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 2108.0
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 2104.6
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 2032.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 1758.6
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 1751.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 1292.9
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 22.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 22.9
FF:10158-103A5 76 years, female 22.9

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1903.8
Pig sample Sample description nTPM
Midbrain
nTPM: 1751.0
Samples: 4

Max nTPM: 2952.8
Min nTPM: 958.7
Sample A Female 2952.8
Sample B Female 1903.3
Sample C Male 1189.3
Sample D Male 958.7
Periaqueductal gray
nTPM: 1452.1
Samples: 3

Max nTPM: 1629.2
Min nTPM: 1346.9
Sample B Female 1629.2
Sample C Male 1380.2
Sample D Male 1346.9
Substantia nigra
nTPM: 1856.5
Samples: 4

Max nTPM: 2114.8
Min nTPM: 1425.5
Sample A Female 2058.4
Sample B Female 2114.8
Sample C Male 1425.5
Sample D Male 1827.3
Superior colliculi
nTPM: 1903.8
Samples: 4

Max nTPM: 2639.3
Min nTPM: 1446.9
Sample A Female 2056.8
Sample B Female 2639.3
Sample C Male 1446.9
Sample D Male 1472.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 2766.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 2766.5
Samples: 4

Max nTPM: 2905.2
Min nTPM: 2614.5
Sample A Male 2905.2
Sample B Male 2766.5
Sample C Female 2614.5
Sample D Female 2779.7

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 26.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 26.6
632492 Antisense, RP_040907_01_D12, Mouse strain C57BL/6J (56 days, male) 27.0
73817934 Antisense, RP_051214_01_A05, Mouse strain C57BL/6J (56 days, male) 26.2

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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.