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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:48.0 nTPM
HPA:48.0 nTPM
GTEx:155.8 nTPM
FANTOM5:89.7 Scaled Tags Per Million
Pig:22.7 nTPM
Mouse:26.2 nTPM
Allen mouse:3.5 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 48.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 47.8
2666 Male, age 74, left hemisphere 54.7
2586 Male, age 75, left hemisphere 51.6
2828 Female, age 72, unknown 48.4
1827 Male, age 72, unknown 48.2
1870 Female, age 42, unknown 47.5
1833 Male, age 53, unknown 47.0
2411 Female, age 72, unknown 46.7
1830 Male, age 51, unknown 46.0
2219 Male, age 76, both hemispheres 44.6
2019 Male, age 18, unknown 43.0
Dorsal raphe nucleus
nTPM: 44.6
1828 Male, age 53, unknown 45.7
2047 Male, age 72, unknown 45.1
2750 Male, age 76, both hemispheres 44.8
2016 Female, age 72, unknown 44.7
2298 Female, age 72, unknown 42.9
Inferior colliculus
nTPM: 45.7
2849 Male, age 72, unknown 49.7
1890 Male, age 53, unknown 44.9
1848 Female, age 42, unknown 44.8
2097 Female, age 72, unknown 43.4
Median raphe nucleus
nTPM: 46.5
2220 Male, age 76, midline 46.5
Pedunculopontine tegmental nucleus
nTPM: 44.7
2334 Male, age 80, both hemispheres 46.5
1921 Female, age 85, both hemispheres 44.2
2338 Male, age 61, both hemispheres 43.5
Periaquaductal grey, anterior
nTPM: 45.1
1947 Male, age 18, unknown 45.5
1795 Male, age 51, unknown 45.1
2502 Female, age 75, unknown 44.7
Periaquaductal grey, dorsal
nTPM: 45.2
1840 Male, age 53, unknown 47.2
1831 Male, age 72, unknown 44.8
2464 Female, age 72, unknown 44.8
2850 Male, age 76, both hemispheres 44.1
Periaquaductal grey, lateral
nTPM: 42.7
2053 Male, age 18, unknown 45.3
2140 Male, age 76, both hemispheres 42.7
2272 Male, age 74, both hemispheres 40.1
Pretectal area
nTPM: 45.1
2825 Male, age 18, unknown 48.8
1816 Male, age 51, unknown 47.5
1815 Male, age 53, unknown 47.3
1817 Female, age 42, unknown 46.7
2407 Male, age 75, both hemispheres 46.7
2007 Male, age 72, unknown 45.6
1944 Female, age 72, unknown 44.9
2316 Male, age 76, right hemisphere 43.0
2667 Female, age 75, unknown 42.8
2224 Female, age 72, unknown 42.4
2273 Male, age 74, both hemispheres 40.7
Red nucleus
nTPM: 48.0
2588 Male, age 74, left hemisphere 54.8
2725 Female, age 75, unknown 51.5
2503 Female, age 72, unknown 50.6
2584 Male, age 75, left hemisphere 49.6
1821 Female, age 72, unknown 47.6
2769 Male, age 72, unknown 46.7
2823 Male, age 76, right hemisphere 46.7
1954 Female, age 42, unknown 46.6
2227 Male, age 72, unknown 46.5
1904 Male, age 53, unknown 45.8
1865 Male, age 51, unknown 45.7
2785 Male, age 18, unknown 44.4
Substantia nigra
nTPM: 47.4
2665 Male, age 74, both hemispheres 50.8
2699 Male, age 18, unknown 49.8
1916 Female, age 42, unknown 49.5
1851 Male, age 51, unknown 47.8
2583 Male, age 75, right hemisphere 47.2
1889 Female, age 72, unknown 46.4
2590 Female, age 75, unknown 46.1
1941 Male, age 53, unknown 45.8
2241 Male, age 72, unknown 45.5
2409 Female, age 72, unknown 45.2
Superior colliculus
nTPM: 46.0
2664 Male, age 75, both hemispheres 49.5
2587 Male, age 74, left hemisphere 48.0
2668 Female, age 75, unknown 46.9
1839 Male, age 51, unknown 46.8
1796 Male, age 53, unknown 45.7
1995 Male, age 72, unknown 44.8
2261 Male, age 18, unknown 44.8
1895 Male, age 76, right hemisphere 44.6
2087 Female, age 72, unknown 44.6
1913 Female, age 42, unknown 44.5
Ventral tegmental area
nTPM: 46.1
1915 Female, age 42, unknown 48.0
2410 Female, age 72, unknown 46.2
1942 Male, age 51, unknown 45.7
2021 Male, age 53, unknown 45.6
2218 Male, age 76, both hemispheres 45.6
2223 Female, age 72, unknown 45.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 155.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 155.8
Samples: 139

Max nTPM: 351.5
Min nTPM: 87.9
Std nTPM: 51.5
Median nTPM: 145.2
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 351.5
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 334.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 311.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 293.8
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 281.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 267.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 263.8
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 252.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 240.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 238.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 237.4
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 236.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 232.5
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 231.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 228.6
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 228.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 222.3
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 221.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 215.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 214.6
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 211.4
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 210.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 208.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 202.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 198.0
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 196.1
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 188.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 188.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 186.9
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 186.3
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 184.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 183.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 179.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 178.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 177.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 176.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 175.0
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 174.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 172.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 172.1
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 172.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 171.1
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 170.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 169.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 166.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 165.4
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 161.4
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 161.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 160.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 160.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 160.3
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 159.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 157.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 156.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 156.4
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 155.3
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 155.2
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 154.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 153.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 152.1
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 152.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 151.9
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 151.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 151.4
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 151.0
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 150.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 147.8
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 146.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 145.3
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 145.2
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 144.4
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 143.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 140.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 140.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 139.2
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 134.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 133.4
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 132.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 132.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 132.2
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 131.3
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 130.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 130.3
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 129.2
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 129.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 128.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 128.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 128.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 127.9
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 127.5
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 127.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 127.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 126.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 126.8
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 126.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 126.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 126.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 123.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 123.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 122.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 122.6
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 122.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 122.1
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 121.5
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 120.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 119.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 119.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 118.9
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 115.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 115.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 114.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 112.9
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 112.7
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 112.7
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 111.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 110.8
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 109.3
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 108.9
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 108.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 108.4
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 108.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 108.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 108.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 106.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 103.8
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 101.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 101.7
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 100.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 98.4
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 97.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 96.4
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 94.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 93.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 93.4
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 93.2
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 91.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 91.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 89.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 87.9
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MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 89.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 89.7
FF:10158-103A5 76 years, female 89.7

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 22.7
Pig sample Sample description nTPM
Midbrain
nTPM: 21.0
Samples: 4

Max nTPM: 23.7
Min nTPM: 16.8
Sample A Female 16.8
Sample B Female 22.6
Sample C Male 20.8
Sample D Male 23.7
Periaqueductal gray
nTPM: 21.9
Samples: 3

Max nTPM: 24.8
Min nTPM: 18.9
Sample B Female 21.9
Sample C Male 24.8
Sample D Male 18.9
Substantia nigra
nTPM: 21.2
Samples: 4

Max nTPM: 30.8
Min nTPM: 11.7
Sample A Female 30.8
Sample B Female 17.6
Sample C Male 24.7
Sample D Male 11.7
Superior colliculi
nTPM: 22.7
Samples: 4

Max nTPM: 29.8
Min nTPM: 17.8
Sample A Female 29.8
Sample B Female 17.8
Sample C Male 20.5
Sample D Male 22.7

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 26.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 26.2
Samples: 4

Max nTPM: 27.4
Min nTPM: 25.2
Sample A Male 27.4
Sample B Male 26.5
Sample C Female 25.2
Sample D Female 25.7

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 3.5
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 3.5
69113632 Antisense, RP_050316_02_E01, Mouse strain C57BL/6J (56 days, male) 3.5

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