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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:121.2 nTPM
HPA:121.2 nTPM
GTEx:93.5 nTPM
FANTOM5:96.7 Scaled Tags Per Million
Pig:107.1 nTPM
Mouse:75.5 nTPM
Allen mouse:6.5 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 121.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 113.4
2586 Male, age 75, left hemisphere 198.3
2828 Female, age 72, unknown 150.2
2666 Male, age 74, left hemisphere 136.7
1827 Male, age 72, unknown 106.9
1870 Female, age 42, unknown 100.9
2219 Male, age 76, both hemispheres 93.9
1833 Male, age 53, unknown 93.8
1830 Male, age 51, unknown 92.8
2411 Female, age 72, unknown 92.0
2019 Male, age 18, unknown 68.8
Dorsal raphe nucleus
nTPM: 112.8
1828 Male, age 53, unknown 130.8
2047 Male, age 72, unknown 129.0
2016 Female, age 72, unknown 117.0
2298 Female, age 72, unknown 95.8
2750 Male, age 76, both hemispheres 91.6
Inferior colliculus
nTPM: 93.8
2849 Male, age 72, unknown 101.5
1848 Female, age 42, unknown 100.7
1890 Male, age 53, unknown 94.0
2097 Female, age 72, unknown 78.9
Median raphe nucleus
nTPM: 96.7
2220 Male, age 76, midline 96.7
Pedunculopontine tegmental nucleus
nTPM: 85.8
2334 Male, age 80, both hemispheres 95.3
1921 Female, age 85, both hemispheres 89.4
2338 Male, age 61, both hemispheres 72.8
Periaquaductal grey, anterior
nTPM: 106.9
1795 Male, age 51, unknown 117.8
1947 Male, age 18, unknown 115.4
2502 Female, age 75, unknown 87.5
Periaquaductal grey, dorsal
nTPM: 99.2
1840 Male, age 53, unknown 107.4
1831 Male, age 72, unknown 101.1
2850 Male, age 76, both hemispheres 96.4
2464 Female, age 72, unknown 91.9
Periaquaductal grey, lateral
nTPM: 96.4
2053 Male, age 18, unknown 121.4
2140 Male, age 76, both hemispheres 92.5
2272 Male, age 74, both hemispheres 75.4
Pretectal area
nTPM: 96.5
2825 Male, age 18, unknown 123.8
2407 Male, age 75, both hemispheres 106.8
2667 Female, age 75, unknown 101.4
1815 Male, age 53, unknown 100.8
1944 Female, age 72, unknown 100.4
1817 Female, age 42, unknown 99.2
1816 Male, age 51, unknown 93.5
2224 Female, age 72, unknown 90.4
2007 Male, age 72, unknown 86.5
2316 Male, age 76, right hemisphere 85.7
2273 Male, age 74, both hemispheres 73.5
Red nucleus
nTPM: 107.6
2584 Male, age 75, left hemisphere 137.2
2503 Female, age 72, unknown 122.6
2588 Male, age 74, left hemisphere 121.5
2725 Female, age 75, unknown 113.7
2769 Male, age 72, unknown 112.0
2227 Male, age 72, unknown 108.6
1954 Female, age 42, unknown 108.1
2823 Male, age 76, right hemisphere 100.5
1821 Female, age 72, unknown 100.1
1865 Male, age 51, unknown 96.8
1904 Male, age 53, unknown 96.5
2785 Male, age 18, unknown 73.2
Substantia nigra
nTPM: 121.2
2699 Male, age 18, unknown 150.3
2583 Male, age 75, right hemisphere 146.0
2665 Male, age 74, both hemispheres 132.9
1916 Female, age 42, unknown 130.8
1851 Male, age 51, unknown 118.3
2590 Female, age 75, unknown 114.9
2409 Female, age 72, unknown 112.7
2241 Male, age 72, unknown 110.9
1889 Female, age 72, unknown 100.3
1941 Male, age 53, unknown 95.0
Superior colliculus
nTPM: 101.2
2664 Male, age 75, both hemispheres 152.0
1796 Male, age 53, unknown 114.4
2668 Female, age 75, unknown 109.8
2261 Male, age 18, unknown 103.7
1839 Male, age 51, unknown 102.9
2087 Female, age 72, unknown 96.3
2587 Male, age 74, left hemisphere 89.1
1995 Male, age 72, unknown 86.0
1913 Female, age 42, unknown 83.7
1895 Male, age 76, right hemisphere 74.3
Ventral tegmental area
nTPM: 108.6
1942 Male, age 51, unknown 123.3
2410 Female, age 72, unknown 116.1
1915 Female, age 42, unknown 110.1
2021 Male, age 53, unknown 110.0
2218 Male, age 76, both hemispheres 100.0
2223 Female, age 72, unknown 92.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 93.5
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 93.5
Samples: 139

Max nTPM: 239.3
Min nTPM: 19.6
Std nTPM: 40.8
Median nTPM: 86.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 239.3
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 213.0
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 191.8
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 190.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 160.1
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 160.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 159.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 158.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 154.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 152.5
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 152.0
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 150.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 148.8
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 145.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 145.0
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 144.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 143.3
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 142.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 139.6
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 138.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 138.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 136.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 135.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 135.8
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 135.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 133.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 132.5
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 131.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 131.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 129.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 129.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 129.2
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 126.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 126.2
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 122.2
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 121.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 121.1
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 121.0
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 118.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 117.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 115.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 114.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 114.8
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 112.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 109.0
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 107.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 106.5
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 106.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 106.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 105.8
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 105.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 104.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 102.4
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 101.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 101.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 100.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 100.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 99.4
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 97.0
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 96.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 96.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 95.3
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 93.2
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 92.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 92.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 91.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 89.4
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 88.0
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 86.4
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 86.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 86.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 84.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 84.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 84.4
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 84.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 83.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 83.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 81.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 81.3
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 78.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 78.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 77.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 77.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 77.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 77.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 75.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 75.2
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 74.5
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 72.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 72.4
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 72.0
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 70.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 70.3
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 70.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 69.6
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 69.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 69.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 67.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 67.1
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 66.1
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 65.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 65.1
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 65.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 64.7
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 63.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 63.5
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 63.3
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 63.0
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 62.8
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 62.7
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 62.3
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 60.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 59.9
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 56.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 55.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 54.3
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 52.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 52.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 50.2
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 50.2
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 49.1
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 48.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 47.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 45.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 43.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 42.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 41.7
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 39.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 39.4
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 38.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 37.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 36.5
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 35.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 32.5
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 29.0
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 26.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 24.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 20.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 19.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 96.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 96.7
FF:10158-103A5 76 years, female 96.7

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 107.1
Pig sample Sample description nTPM
Midbrain
nTPM: 101.6
Samples: 4

Max nTPM: 168.3
Min nTPM: 67.8
Sample A Female 67.8
Sample B Female 83.8
Sample C Male 168.3
Sample D Male 86.6
Periaqueductal gray
nTPM: 76.5
Samples: 3

Max nTPM: 86.7
Min nTPM: 60.3
Sample B Female 86.7
Sample C Male 82.4
Sample D Male 60.3
Substantia nigra
nTPM: 107.1
Samples: 4

Max nTPM: 128.8
Min nTPM: 77.9
Sample A Female 110.0
Sample B Female 77.9
Sample C Male 128.8
Sample D Male 111.6
Superior colliculi
nTPM: 96.3
Samples: 4

Max nTPM: 135.8
Min nTPM: 49.2
Sample A Female 94.2
Sample B Female 49.2
Sample C Male 135.8
Sample D Male 106.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 75.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 75.5
Samples: 4

Max nTPM: 80.3
Min nTPM: 71.4
Sample A Male 80.3
Sample B Male 75.8
Sample C Female 71.4
Sample D Female 74.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 6.5
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 6.5
71358662 Antisense, RP_050725_03_F12, Mouse strain C57BL/6J (56 days, male) 6.8
68845287 Antisense, RP_050224_01_E03, Mouse strain C57BL/6J (56 days, male) 6.3

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