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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
PRIMARY MOUSE DATA
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:84.1 nTPM
HPA:84.1 nTPM
GTEx:67.0 nTPM
FANTOM5:30.1 Scaled Tags Per Million
Pig:93.0 nTPM
Mouse:135.7 nTPM
Allen mouse:12.6 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 84.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 59.7
2586 Male, age 75, left hemisphere 101.6
2666 Male, age 74, left hemisphere 80.1
2219 Male, age 76, both hemispheres 79.9
1827 Male, age 72, unknown 63.1
2828 Female, age 72, unknown 52.2
2411 Female, age 72, unknown 49.7
1833 Male, age 53, unknown 44.9
2019 Male, age 18, unknown 43.7
1870 Female, age 42, unknown 42.5
1830 Male, age 51, unknown 38.9
Dorsal raphe nucleus
nTPM: 66.5
2047 Male, age 72, unknown 83.6
1828 Male, age 53, unknown 82.4
2298 Female, age 72, unknown 76.8
2750 Male, age 76, both hemispheres 47.9
2016 Female, age 72, unknown 41.8
Inferior colliculus
nTPM: 47.4
1848 Female, age 42, unknown 55.6
2849 Male, age 72, unknown 54.7
2097 Female, age 72, unknown 41.1
1890 Male, age 53, unknown 38.2
Median raphe nucleus
nTPM: 72.4
2220 Male, age 76, midline 72.4
Pedunculopontine tegmental nucleus
nTPM: 52.2
2334 Male, age 80, both hemispheres 67.0
1921 Female, age 85, both hemispheres 56.3
2338 Male, age 61, both hemispheres 33.4
Periaquaductal grey, anterior
nTPM: 64.6
1795 Male, age 51, unknown 75.9
1947 Male, age 18, unknown 69.2
2502 Female, age 75, unknown 48.6
Periaquaductal grey, dorsal
nTPM: 48.2
1840 Male, age 53, unknown 64.1
2850 Male, age 76, both hemispheres 50.0
1831 Male, age 72, unknown 40.7
2464 Female, age 72, unknown 37.9
Periaquaductal grey, lateral
nTPM: 44.2
2140 Male, age 76, both hemispheres 45.5
2053 Male, age 18, unknown 44.2
2272 Male, age 74, both hemispheres 42.9
Pretectal area
nTPM: 66.8
1816 Male, age 51, unknown 92.9
2407 Male, age 75, both hemispheres 89.7
1944 Female, age 72, unknown 78.6
1817 Female, age 42, unknown 74.5
2007 Male, age 72, unknown 71.5
2667 Female, age 75, unknown 69.9
1815 Male, age 53, unknown 65.6
2224 Female, age 72, unknown 59.2
2825 Male, age 18, unknown 53.8
2273 Male, age 74, both hemispheres 49.1
2316 Male, age 76, right hemisphere 30.4
Red nucleus
nTPM: 27.4
2584 Male, age 75, left hemisphere 80.0
2785 Male, age 18, unknown 43.6
1821 Female, age 72, unknown 33.0
1954 Female, age 42, unknown 28.2
2769 Male, age 72, unknown 26.3
2227 Male, age 72, unknown 26.1
1865 Male, age 51, unknown 21.4
1904 Male, age 53, unknown 17.8
2503 Female, age 72, unknown 17.0
2823 Male, age 76, right hemisphere 14.9
2588 Male, age 74, left hemisphere 14.0
2725 Female, age 75, unknown 6.5
Substantia nigra
nTPM: 84.1
1916 Female, age 42, unknown 104.0
2590 Female, age 75, unknown 103.1
2665 Male, age 74, both hemispheres 96.4
1851 Male, age 51, unknown 92.6
2583 Male, age 75, right hemisphere 91.3
1941 Male, age 53, unknown 90.5
2241 Male, age 72, unknown 74.3
1889 Female, age 72, unknown 72.2
2699 Male, age 18, unknown 61.0
2409 Female, age 72, unknown 55.2
Superior colliculus
nTPM: 63.8
2664 Male, age 75, both hemispheres 120.2
2668 Female, age 75, unknown 112.7
2261 Male, age 18, unknown 70.4
1796 Male, age 53, unknown 70.2
2087 Female, age 72, unknown 68.8
1839 Male, age 51, unknown 49.7
1895 Male, age 76, right hemisphere 43.1
1995 Male, age 72, unknown 35.6
1913 Female, age 42, unknown 35.5
2587 Male, age 74, left hemisphere 31.3
Ventral tegmental area
nTPM: 66.2
2218 Male, age 76, both hemispheres 74.1
1915 Female, age 42, unknown 73.7
2410 Female, age 72, unknown 71.6
1942 Male, age 51, unknown 62.6
2223 Female, age 72, unknown 60.8
2021 Male, age 53, unknown 54.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 67.0
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 67.0
Samples: 139

Max nTPM: 228.9
Min nTPM: 6.1
Std nTPM: 37.4
Median nTPM: 60.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 228.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 224.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 163.8
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 155.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 138.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 134.2
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 132.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 130.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 129.9
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 129.6
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 124.4
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 123.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 122.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 115.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 108.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 108.1
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 107.6
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 107.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 106.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 104.7
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 103.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 102.9
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 102.3
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 102.1
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 97.9
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 96.7
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 95.1
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 92.9
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 92.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 92.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 91.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 91.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 89.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 88.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 87.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 85.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 85.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 83.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 82.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 78.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 77.8
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 77.6
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 76.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 75.4
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 75.1
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 74.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 73.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 73.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 73.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 72.9
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 72.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 72.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 71.1
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 69.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 68.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 68.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 67.8
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 66.9
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 65.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 65.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 64.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 64.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 63.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 63.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 63.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 63.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 62.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 60.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 60.7
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 60.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 59.4
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 59.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 58.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 58.1
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 58.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 57.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 56.8
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 56.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 56.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 55.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 55.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 53.7
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 53.2
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 51.5
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 51.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 51.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 50.9
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 50.7
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 49.1
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 49.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 47.4
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 46.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 46.5
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 45.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 45.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 44.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 44.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 43.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 42.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 42.3
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 42.1
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 41.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 40.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 40.4
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 40.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 39.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 38.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 37.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 37.4
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 37.0
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 36.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 36.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 35.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 35.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 34.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 34.2
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 34.2
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 33.7
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 33.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 32.7
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 32.5
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 32.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 31.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 30.6
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 29.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 29.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 29.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 23.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 22.7
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 22.5
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 22.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 19.5
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 18.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 18.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 17.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 15.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 14.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 12.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 6.1
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 30.1
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 30.1
FF:10158-103A5 76 years, female 30.1

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 93.0
Pig sample Sample description nTPM
Midbrain
nTPM: 84.2
Samples: 4

Max nTPM: 132.0
Min nTPM: 39.8
Sample A Female 39.8
Sample B Female 59.2
Sample C Male 132.0
Sample D Male 105.7
Periaqueductal gray
nTPM: 69.7
Samples: 3

Max nTPM: 92.8
Min nTPM: 55.6
Sample B Female 55.6
Sample C Male 92.8
Sample D Male 60.6
Substantia nigra
nTPM: 90.7
Samples: 4

Max nTPM: 134.1
Min nTPM: 23.4
Sample A Female 134.1
Sample B Female 73.0
Sample C Male 132.1
Sample D Male 23.4
Superior colliculi
nTPM: 93.0
Samples: 4

Max nTPM: 122.1
Min nTPM: 50.3
Sample A Female 91.8
Sample B Female 50.3
Sample C Male 122.1
Sample D Male 107.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 135.7
Mouse sample Sample description nTPM
Midbrain
nTPM: 135.7
Samples: 4

Max nTPM: 147.9
Min nTPM: 124.2
Sample A Male 124.2
Sample B Male 139.1
Sample C Female 147.9
Sample D Female 131.7

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 12.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 12.6
69169911 Antisense, RP_050321_04_D11, Mouse strain C57BL/6J (56 days, male) 12.6

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