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IGFBP7
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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

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No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:138.7 nTPM
HPA:138.7 nTPM
GTEx:202.5 nTPM
FANTOM5:549.2 Scaled Tags Per Million
Pig:116.3 nTPM
Mouse:28.5 nTPM
Allen mouse:3.5 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 138.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 105.0
2828 Female, age 72, unknown 127.3
2019 Male, age 18, unknown 116.4
2586 Male, age 75, left hemisphere 106.2
1833 Male, age 53, unknown 105.4
2666 Male, age 74, left hemisphere 105.3
1830 Male, age 51, unknown 105.0
1827 Male, age 72, unknown 104.5
1870 Female, age 42, unknown 103.0
2411 Female, age 72, unknown 97.9
2219 Male, age 76, both hemispheres 79.3
Dorsal raphe nucleus
nTPM: 120.1
2016 Female, age 72, unknown 135.1
1828 Male, age 53, unknown 120.7
2047 Male, age 72, unknown 119.3
2298 Female, age 72, unknown 117.7
2750 Male, age 76, both hemispheres 107.6
Inferior colliculus
nTPM: 131.5
1848 Female, age 42, unknown 143.6
2097 Female, age 72, unknown 136.7
1890 Male, age 53, unknown 133.7
2849 Male, age 72, unknown 111.9
Median raphe nucleus
nTPM: 89.7
2220 Male, age 76, midline 89.7
Pedunculopontine tegmental nucleus
nTPM: 122.6
2338 Male, age 61, both hemispheres 163.1
2334 Male, age 80, both hemispheres 109.2
1921 Female, age 85, both hemispheres 95.4
Periaquaductal grey, anterior
nTPM: 121.9
2502 Female, age 75, unknown 129.0
1947 Male, age 18, unknown 121.7
1795 Male, age 51, unknown 115.0
Periaquaductal grey, dorsal
nTPM: 107.8
2464 Female, age 72, unknown 114.5
1840 Male, age 53, unknown 111.7
2850 Male, age 76, both hemispheres 106.7
1831 Male, age 72, unknown 98.3
Periaquaductal grey, lateral
nTPM: 138.7
2272 Male, age 74, both hemispheres 179.1
2140 Male, age 76, both hemispheres 124.5
2053 Male, age 18, unknown 112.3
Pretectal area
nTPM: 104.8
2273 Male, age 74, both hemispheres 121.6
1817 Female, age 42, unknown 118.2
2224 Female, age 72, unknown 113.3
2316 Male, age 76, right hemisphere 111.5
2667 Female, age 75, unknown 107.0
1816 Male, age 51, unknown 102.3
2825 Male, age 18, unknown 100.5
1944 Female, age 72, unknown 96.4
1815 Male, age 53, unknown 95.0
2407 Male, age 75, both hemispheres 94.3
2007 Male, age 72, unknown 93.0
Red nucleus
nTPM: 131.0
2227 Male, age 72, unknown 164.2
2769 Male, age 72, unknown 154.8
1954 Female, age 42, unknown 140.0
1821 Female, age 72, unknown 139.3
2503 Female, age 72, unknown 132.4
1904 Male, age 53, unknown 129.7
1865 Male, age 51, unknown 129.3
2823 Male, age 76, right hemisphere 128.1
2725 Female, age 75, unknown 126.9
2785 Male, age 18, unknown 118.5
2588 Male, age 74, left hemisphere 117.0
2584 Male, age 75, left hemisphere 91.6
Substantia nigra
nTPM: 98.9
2699 Male, age 18, unknown 110.6
2665 Male, age 74, both hemispheres 109.6
1851 Male, age 51, unknown 107.0
1889 Female, age 72, unknown 103.6
2590 Female, age 75, unknown 99.6
1916 Female, age 42, unknown 95.1
1941 Male, age 53, unknown 94.0
2241 Male, age 72, unknown 91.9
2583 Male, age 75, right hemisphere 89.9
2409 Female, age 72, unknown 87.7
Superior colliculus
nTPM: 106.3
1995 Male, age 72, unknown 112.5
2587 Male, age 74, left hemisphere 112.1
2261 Male, age 18, unknown 111.8
2087 Female, age 72, unknown 109.7
1895 Male, age 76, right hemisphere 108.9
1839 Male, age 51, unknown 108.0
1796 Male, age 53, unknown 104.0
1913 Female, age 42, unknown 103.7
2668 Female, age 75, unknown 98.2
2664 Male, age 75, both hemispheres 93.9
Ventral tegmental area
nTPM: 105.5
2223 Female, age 72, unknown 116.4
2021 Male, age 53, unknown 113.8
1915 Female, age 42, unknown 107.1
1942 Male, age 51, unknown 100.6
2410 Female, age 72, unknown 99.0
2218 Male, age 76, both hemispheres 95.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 202.5
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 202.5
Samples: 139

Max nTPM: 572.2
Min nTPM: 56.4
Std nTPM: 95.0
Median nTPM: 178.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 572.2
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 535.9
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 529.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 438.7
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 402.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 399.6
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 389.7
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 371.6
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 359.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 357.5
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 356.6
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 355.7
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 343.4
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 341.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 338.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 325.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 313.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 308.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 290.8
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 289.3
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 286.2
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 281.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 279.6
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 279.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 273.2
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 268.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 268.0
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 267.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 266.6
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 265.2
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 262.8
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 261.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 257.4
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 255.4
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 253.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 253.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 251.5
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 250.9
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 249.2
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 246.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 237.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 232.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 231.7
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 230.6
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 230.1
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 229.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 217.7
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 216.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 214.0
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 212.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 208.5
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 205.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 204.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 200.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 200.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 200.1
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 199.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 198.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 197.0
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 196.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 194.3
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 190.7
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 190.6
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 190.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 188.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 187.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 186.8
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 185.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 184.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 178.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 176.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 176.7
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 175.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 175.0
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 174.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 174.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 171.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 168.2
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 168.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 167.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 164.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 163.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 161.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 160.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 159.0
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 157.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 157.1
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 156.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 156.6
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 156.5
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 154.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 154.1
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 152.9
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 152.4
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 150.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 148.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 148.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 148.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 145.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 141.6
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 139.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 137.2
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 136.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 135.3
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 134.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 130.7
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 129.4
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 129.0
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 128.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 128.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 127.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 126.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 124.3
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 123.7
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 122.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 121.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 121.0
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 115.6
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 115.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 111.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 109.2
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 108.7
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 108.5
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 105.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 105.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 104.7
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 104.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 103.9
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 94.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 91.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 89.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 88.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 88.0
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 85.8
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 85.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 84.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 69.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 62.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 56.4
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 549.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 549.2
FF:10158-103A5 76 years, female 549.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 116.3
Pig sample Sample description nTPM
Midbrain
nTPM: 75.2
Samples: 4

Max nTPM: 96.8
Min nTPM: 54.8
Sample A Female 88.4
Sample B Female 54.8
Sample C Male 96.8
Sample D Male 60.9
Periaqueductal gray
nTPM: 52.0
Samples: 3

Max nTPM: 59.5
Min nTPM: 44.9
Sample B Female 51.6
Sample C Male 59.5
Sample D Male 44.9
Substantia nigra
nTPM: 95.6
Samples: 4

Max nTPM: 157.8
Min nTPM: 56.3
Sample A Female 90.0
Sample B Female 157.8
Sample C Male 56.3
Sample D Male 78.4
Superior colliculi
nTPM: 116.3
Samples: 4

Max nTPM: 187.1
Min nTPM: 84.8
Sample A Female 104.0
Sample B Female 187.1
Sample C Male 84.8
Sample D Male 89.3

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 28.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 28.6
Samples: 4

Max nTPM: 30.3
Min nTPM: 26.4
Sample A Male 26.4
Sample B Male 28.8
Sample C Female 28.7
Sample D Female 30.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 3.5
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 3.5
81654139 Antisense, RP_090205_01_B05, Mouse strain C57BL/6J (56 days, male) 3.5

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