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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:100.1 nTPM
HPA:100.1 nTPM
GTEx:80.1 nTPM
FANTOM5:33.4 Scaled Tags Per Million
Pig:33.9 nTPM
Mouse:178.3 nTPM
Allen mouse:16.4 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 100.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 92.1
2586 Male, age 75, left hemisphere 101.5
2411 Female, age 72, unknown 100.6
1833 Male, age 53, unknown 96.2
1830 Male, age 51, unknown 95.5
1870 Female, age 42, unknown 93.7
2019 Male, age 18, unknown 89.5
2828 Female, age 72, unknown 88.5
2666 Male, age 74, left hemisphere 87.3
1827 Male, age 72, unknown 85.1
2219 Male, age 76, both hemispheres 83.5
Dorsal raphe nucleus
nTPM: 84.5
2750 Male, age 76, both hemispheres 94.0
1828 Male, age 53, unknown 86.8
2016 Female, age 72, unknown 83.8
2047 Male, age 72, unknown 82.4
2298 Female, age 72, unknown 75.7
Inferior colliculus
nTPM: 82.0
2849 Male, age 72, unknown 84.0
1890 Male, age 53, unknown 83.2
1848 Female, age 42, unknown 81.1
2097 Female, age 72, unknown 79.8
Median raphe nucleus
nTPM: 78.8
2220 Male, age 76, midline 78.8
Pedunculopontine tegmental nucleus
nTPM: 78.4
2334 Male, age 80, both hemispheres 82.4
1921 Female, age 85, both hemispheres 81.7
2338 Male, age 61, both hemispheres 71.0
Periaquaductal grey, anterior
nTPM: 81.5
2502 Female, age 75, unknown 86.2
1947 Male, age 18, unknown 82.1
1795 Male, age 51, unknown 76.1
Periaquaductal grey, dorsal
nTPM: 76.0
2464 Female, age 72, unknown 84.4
1831 Male, age 72, unknown 74.8
1840 Male, age 53, unknown 73.8
2850 Male, age 76, both hemispheres 70.8
Periaquaductal grey, lateral
nTPM: 74.2
2053 Male, age 18, unknown 76.7
2272 Male, age 74, both hemispheres 73.3
2140 Male, age 76, both hemispheres 72.6
Pretectal area
nTPM: 81.0
2407 Male, age 75, both hemispheres 90.9
2316 Male, age 76, right hemisphere 85.8
1815 Male, age 53, unknown 85.3
1817 Female, age 42, unknown 85.0
2825 Male, age 18, unknown 85.0
2007 Male, age 72, unknown 83.2
2667 Female, age 75, unknown 81.6
1944 Female, age 72, unknown 75.0
1816 Male, age 51, unknown 74.9
2224 Female, age 72, unknown 74.0
2273 Male, age 74, both hemispheres 70.8
Red nucleus
nTPM: 100.1
1904 Male, age 53, unknown 106.1
2227 Male, age 72, unknown 104.9
2588 Male, age 74, left hemisphere 104.5
2769 Male, age 72, unknown 104.1
1865 Male, age 51, unknown 103.7
2503 Female, age 72, unknown 102.6
2823 Male, age 76, right hemisphere 99.9
1821 Female, age 72, unknown 99.0
1954 Female, age 42, unknown 97.8
2785 Male, age 18, unknown 94.5
2584 Male, age 75, left hemisphere 94.3
2725 Female, age 75, unknown 90.3
Substantia nigra
nTPM: 86.0
2699 Male, age 18, unknown 93.8
1851 Male, age 51, unknown 93.5
2583 Male, age 75, right hemisphere 92.6
1916 Female, age 42, unknown 88.8
1889 Female, age 72, unknown 84.7
2409 Female, age 72, unknown 84.5
2590 Female, age 75, unknown 83.1
2665 Male, age 74, both hemispheres 82.8
1941 Male, age 53, unknown 79.7
2241 Male, age 72, unknown 76.2
Superior colliculus
nTPM: 87.5
1995 Male, age 72, unknown 96.4
1913 Female, age 42, unknown 96.0
1895 Male, age 76, right hemisphere 91.6
2668 Female, age 75, unknown 91.3
1839 Male, age 51, unknown 88.1
2664 Male, age 75, both hemispheres 87.4
2587 Male, age 74, left hemisphere 85.4
1796 Male, age 53, unknown 82.8
2087 Female, age 72, unknown 78.8
2261 Male, age 18, unknown 77.4
Ventral tegmental area
nTPM: 87.2
2410 Female, age 72, unknown 96.8
1915 Female, age 42, unknown 88.0
2223 Female, age 72, unknown 87.5
1942 Male, age 51, unknown 85.9
2021 Male, age 53, unknown 82.9
2218 Male, age 76, both hemispheres 81.9

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 80.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 80.1
Samples: 139

Max nTPM: 207.5
Min nTPM: 37.8
Std nTPM: 27.7
Median nTPM: 71.9
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 207.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 189.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 166.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 141.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 140.7
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 136.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 133.2
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 132.1
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 126.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 124.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 121.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 121.2
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 119.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 113.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 110.7
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 109.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 108.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 108.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 108.1
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 105.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 105.4
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 104.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 103.3
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 103.0
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 102.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 102.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 102.7
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 100.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 98.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 97.9
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 96.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 95.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 94.2
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 93.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 93.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 93.6
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 91.9
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 91.4
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 91.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 88.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 87.5
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 86.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 86.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 86.6
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 85.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 83.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 82.5
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 82.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 82.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 82.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 82.3
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 82.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 82.0
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 80.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 80.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 79.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 79.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 79.0
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 78.8
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 78.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 77.2
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 76.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 75.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 74.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 74.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 74.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 74.2
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 73.8
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 73.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 71.9
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 71.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 71.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 71.5
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 71.5
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 71.3
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 71.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 71.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 71.0
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 70.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 70.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 70.0
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 69.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 69.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 69.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 69.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 68.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 68.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 67.9
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 67.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 67.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 67.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 66.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 66.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 65.9
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 65.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 65.4
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 65.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 64.5
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 63.5
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 62.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 62.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 62.5
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 62.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 61.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 61.0
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 61.0
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 60.5
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 60.3
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 60.3
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 59.5
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 59.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 58.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 58.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 58.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 57.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 57.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 56.6
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 56.1
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 56.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 56.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 55.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 55.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 54.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 54.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 54.0
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 53.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 51.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 49.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 49.0
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 48.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 47.9
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 46.4
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 45.7
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 44.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 43.7
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 41.9
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 41.7
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 40.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 37.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 33.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 33.4
FF:10158-103A5 76 years, female 33.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 33.9
Pig sample Sample description nTPM
Midbrain
nTPM: 34.0
Samples: 4

Max nTPM: 44.0
Min nTPM: 30.2
Sample A Female 44.0
Sample B Female 31.4
Sample C Male 30.2
Sample D Male 30.2
Periaqueductal gray
nTPM: 27.1
Samples: 3

Max nTPM: 28.6
Min nTPM: 25.7
Sample B Female 28.6
Sample C Male 26.9
Sample D Male 25.7
Substantia nigra
nTPM: 31.3
Samples: 4

Max nTPM: 36.2
Min nTPM: 23.0
Sample A Female 34.9
Sample B Female 23.0
Sample C Male 31.2
Sample D Male 36.2
Superior colliculi
nTPM: 32.0
Samples: 4

Max nTPM: 39.7
Min nTPM: 17.9
Sample A Female 35.7
Sample B Female 17.9
Sample C Male 34.5
Sample D Male 39.7

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 178.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 178.3
Samples: 4

Max nTPM: 192.0
Min nTPM: 163.9
Sample A Male 192.0
Sample B Male 169.6
Sample C Female 163.9
Sample D Female 187.8

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 16.4
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 16.4
69080509 Antisense, RP_050324_02_B10, Mouse strain C57BL/6J (56 days, male) 16.4

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