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FAM219A
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  • FAM219A
BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

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No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:84.8 nTPM
HPA:84.8 nTPM
GTEx:77.6 nTPM
FANTOM5:183.5 Scaled Tags Per Million
Pig:25.2 nTPM
Mouse:90.2 nTPM
Allen mouse:2.7 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 84.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 80.5
2586 Male, age 75, left hemisphere 111.7
2666 Male, age 74, left hemisphere 110.2
2828 Female, age 72, unknown 77.6
2219 Male, age 76, both hemispheres 77.3
1833 Male, age 53, unknown 73.4
1827 Male, age 72, unknown 72.6
2019 Male, age 18, unknown 71.6
1870 Female, age 42, unknown 71.5
1830 Male, age 51, unknown 70.3
2411 Female, age 72, unknown 69.0
Dorsal raphe nucleus
nTPM: 75.4
2047 Male, age 72, unknown 88.2
2750 Male, age 76, both hemispheres 81.3
1828 Male, age 53, unknown 77.1
2016 Female, age 72, unknown 67.5
2298 Female, age 72, unknown 62.9
Inferior colliculus
nTPM: 67.7
2849 Male, age 72, unknown 70.1
1890 Male, age 53, unknown 69.2
1848 Female, age 42, unknown 68.8
2097 Female, age 72, unknown 62.7
Median raphe nucleus
nTPM: 79.6
2220 Male, age 76, midline 79.6
Pedunculopontine tegmental nucleus
nTPM: 72.5
2334 Male, age 80, both hemispheres 76.7
1921 Female, age 85, both hemispheres 74.8
2338 Male, age 61, both hemispheres 66.0
Periaquaductal grey, anterior
nTPM: 73.2
1947 Male, age 18, unknown 80.0
1795 Male, age 51, unknown 71.4
2502 Female, age 75, unknown 68.2
Periaquaductal grey, dorsal
nTPM: 57.3
2464 Female, age 72, unknown 58.6
1840 Male, age 53, unknown 57.3
2850 Male, age 76, both hemispheres 57.3
1831 Male, age 72, unknown 55.9
Periaquaductal grey, lateral
nTPM: 62.5
2272 Male, age 74, both hemispheres 64.9
2140 Male, age 76, both hemispheres 61.4
2053 Male, age 18, unknown 61.1
Pretectal area
nTPM: 70.2
2007 Male, age 72, unknown 86.5
1944 Female, age 72, unknown 84.0
1817 Female, age 42, unknown 77.4
1816 Male, age 51, unknown 73.6
1815 Male, age 53, unknown 70.4
2407 Male, age 75, both hemispheres 69.4
2825 Male, age 18, unknown 68.4
2224 Female, age 72, unknown 65.8
2316 Male, age 76, right hemisphere 64.6
2667 Female, age 75, unknown 58.9
2273 Male, age 74, both hemispheres 53.0
Red nucleus
nTPM: 77.8
2588 Male, age 74, left hemisphere 101.2
2725 Female, age 75, unknown 87.2
2584 Male, age 75, left hemisphere 85.5
2785 Male, age 18, unknown 82.0
2227 Male, age 72, unknown 78.8
2769 Male, age 72, unknown 78.8
1954 Female, age 42, unknown 75.1
1904 Male, age 53, unknown 74.5
2503 Female, age 72, unknown 73.8
1865 Male, age 51, unknown 71.4
1821 Female, age 72, unknown 68.7
2823 Male, age 76, right hemisphere 56.7
Substantia nigra
nTPM: 84.8
1916 Female, age 42, unknown 114.8
1941 Male, age 53, unknown 94.4
1851 Male, age 51, unknown 89.8
2665 Male, age 74, both hemispheres 87.2
2583 Male, age 75, right hemisphere 85.9
1889 Female, age 72, unknown 82.6
2699 Male, age 18, unknown 81.5
2590 Female, age 75, unknown 74.1
2241 Male, age 72, unknown 71.5
2409 Female, age 72, unknown 66.2
Superior colliculus
nTPM: 70.4
2668 Female, age 75, unknown 88.6
2664 Male, age 75, both hemispheres 75.1
2587 Male, age 74, left hemisphere 74.4
1796 Male, age 53, unknown 73.1
1839 Male, age 51, unknown 73.0
2261 Male, age 18, unknown 70.3
1895 Male, age 76, right hemisphere 66.2
1913 Female, age 42, unknown 65.3
2087 Female, age 72, unknown 60.3
1995 Male, age 72, unknown 57.6
Ventral tegmental area
nTPM: 79.4
1915 Female, age 42, unknown 90.0
2218 Male, age 76, both hemispheres 84.5
1942 Male, age 51, unknown 82.4
2410 Female, age 72, unknown 77.8
2223 Female, age 72, unknown 72.0
2021 Male, age 53, unknown 69.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 77.6
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 77.6
Samples: 139

Max nTPM: 142.1
Min nTPM: 37.5
Std nTPM: 19.2
Median nTPM: 79.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 142.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 135.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 122.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 115.9
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 115.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 115.1
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 114.4
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 110.5
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 109.8
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 105.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 102.9
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 102.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 102.3
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 102.1
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 101.7
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 101.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 100.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 97.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 97.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 97.1
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 96.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 96.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 94.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 94.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 94.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 93.9
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 93.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 93.3
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 91.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 90.9
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 89.5
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 89.4
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 89.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 89.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 88.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 88.1
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 87.8
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 87.3
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 86.7
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 86.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 86.4
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 86.2
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 85.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 85.6
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 85.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 84.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 84.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 84.2
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 83.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 83.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 83.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 82.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 82.7
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 82.5
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 82.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 81.7
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 81.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 81.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 80.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 80.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 80.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 80.2
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 80.1
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 80.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 80.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 79.9
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 79.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 79.5
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 79.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 79.1
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 78.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 78.1
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 77.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 77.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 75.5
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 75.0
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 74.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 74.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 74.5
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 74.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 74.4
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 74.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 74.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 73.2
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 72.9
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 72.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 72.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 71.5
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 71.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 71.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 70.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 69.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 69.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 69.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 69.3
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 69.1
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 68.5
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 66.6
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 66.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 66.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 65.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 65.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 65.6
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 65.4
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 64.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 63.5
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 61.7
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 61.7
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 60.0
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 59.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 58.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 58.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 58.1
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 58.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 56.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 55.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 55.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 55.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 54.5
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 54.5
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 54.0
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 53.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 53.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 53.2
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 52.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 52.3
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 52.1
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 51.6
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 50.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 50.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 49.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 49.4
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 48.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 48.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 47.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 46.1
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 45.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 40.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 37.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 183.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 183.5
FF:10158-103A5 76 years, female 183.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 25.2
Pig sample Sample description nTPM
Midbrain
nTPM: 24.4
Samples: 4

Max nTPM: 29.9
Min nTPM: 19.5
Sample A Female 22.2
Sample B Female 19.5
Sample C Male 29.9
Sample D Male 26.0
Periaqueductal gray
nTPM: 20.2
Samples: 3

Max nTPM: 22.9
Min nTPM: 18.7
Sample B Female 18.7
Sample C Male 22.9
Sample D Male 19.0
Substantia nigra
nTPM: 25.2
Samples: 4

Max nTPM: 30.6
Min nTPM: 20.0
Sample A Female 28.2
Sample B Female 20.0
Sample C Male 30.6
Sample D Male 21.9
Superior colliculi
nTPM: 22.7
Samples: 4

Max nTPM: 26.9
Min nTPM: 13.8
Sample A Female 23.5
Sample B Female 13.8
Sample C Male 26.6
Sample D Male 26.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 90.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 90.2
Samples: 4

Max nTPM: 91.2
Min nTPM: 88.5
Sample A Male 88.5
Sample B Male 90.5
Sample C Female 91.2
Sample D Female 90.7

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.7
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.7
71211746 Antisense, RP_050816_02_D01, Mouse strain C57BL/6J (56 days, male) 2.7

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