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C10orf82
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                                • C10orf82
                                IMMUNE CELL CELL LINEAGES Show tissue menu
                                B-CELLS DENDRITIC CELLS GRANULOCYTES MONOCYTES NK-CELLS PROGENITORS T-CELLS TOTAL PBMC
                                Immune cell proteome
                                GENERAL INFORMATIONi

                                General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

                                Gene namei

                                Official gene symbol, which is typically a short form of the gene name, according to HGNC.

                                C10orf82
                                Gene descriptioni

                                Full gene name according to HGNC.

                                Chromosome 10 open reading frame 82
                                Predicted locationi

                                All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

                                • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

                                • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

                                The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

                                Read more
                                Intracellular
                                IMMUNE CELL SECTION SUMMARY
                                Immune cell type expression clusteri

                                The RNA data is used to cluster genes according to their expression across immune cells. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                Read more
                                Basophils - DNA binding (mainly)
                                Immune cell type specificityi

                                The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.

                                Read more
                                Immune cell enriched (basophil)
                                Tau specificity scorei

                                Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.

                                Read more
                                1.00
                                Immune cell type distributioni

                                The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.

                                Read more
                                Detected in single
                                Immune cell lineage specificityi

                                The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: lineage enriched, group enriched, lineage enhanced, low lineage specificity and not detected. Lineages include B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells.

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                                Lineage enriched (granulocytes)
                                Immune cell lineage distributioni

                                The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                Read more
                                Detected in single
                                IMMUNE CELL TYPE EXPRESSION (RNA)i

                                Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.

                                HPA dataseti

                                The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC).

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                                Lineage
                                Expression
                                Alphabetical
                                Immune cell type specificity: Immune cell enriched (basophil)
                                BasophilEosinophilNeutrophilClassical monocyteNon-classical monocyteIntermediate monocyteT-regGdT-cellMAIT T-cellMemory CD4 T-cellNaive CD4 T-cellMemory CD8 T-cellNaive CD8 T-cellMemory B-cellNaive B-cellPlasmacytoid DCMyeloid DCNK-cellTotal PBMC024681012nTPMGranulocytesMonocytesT-cellsB-cellsDendritic cellsNK-cellsTotal PBMC
                                Monaco dataseti

                                The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al.

                                Read more
                                Lineage
                                Expression
                                Alphabetical
                                BasophilNeutrophilClassical monocyteNon-classical monocyteIntermediate monocyteT-regMAIT T-cellNaive CD4 T-cellVd2 gdTCRMemory CD4 T-cell Th1/Th17Memory CD4 T-cell Th17Memory CD4 T-cell Th2Non-Vd2 gdTCRMemory CD4 T-cell Th1Memory CD4 T-cell TFHTerminal effector memory CD4 T-cellNaive CD8 T-cellCentral memory CD8 T-cellEffector memory CD8 T-cellTerminal effector memory CD8 T-cellNaive B-cellNon-switched memory B-cellPlasmablastSwitched memory B-cellExhausted memory B-cellPlasmacytoid DCMyeloid DCNK-cellProgenitor cellTotal PBMC01020304050nTPMGranulocytesMonocytesT-cellsB-cellsDendritic cellsNK-cellsProgenitorsTotal PBMC
                                Schmiedel dataseti

                                Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset.

                                Read more
                                Lineage
                                Expression
                                Alphabetical
                                Classical monocyteNon-classical monocyteNaive CD4 T-cellMemory CD4 T-cell TFHMemory CD4 T-cell Th1Memory CD4 T-cell Th1/Th17Memory CD4 T-cell Th17Memory CD4 T-cell Th2Memory T-regNaive CD4 T-cell activatedNaive CD8 T-cell activatedNaive T-regNaive CD8 T-cellNaive B-cellNK-cell0246810TPMMonocytesT-cellsB-cellsNK-cells
                                EXPRESSION CLUSTERING & CORRELATIONi

                                The RNA data was used to cluster genes according to their expression across samples. The resulting clusters have been manually annotated to describe common features in terms of function and specificity. The annotation of the cluster is displayed together with a confidence score of the gene's assignment to the cluster. The confidence is calculated as the fraction of times the gene was assigned to this cluster in repeated calculations and is reported between 0 to 1, where 1 is the highest possible confidence. The clustering results are shown in a UMAP, where the cluster this gene was assigned to is highlighted as a colored area in which most of the cluster genes reside. A table shows the 15 most similar genes in terms of expression profile.

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                                C10orf82 is part of cluster 46 Basophils - DNA binding with confidencei

                                Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster. A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings.

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                                1
                                341 genes in cluster
                                Go to interactive expression cluster page
                                15 nearest neighbours based on immune cell RNA expression
                                Neighbouri

                                Gene name according to HGNC.

                                Descriptioni

                                Gene description according to HGNC.

                                Correlationi

                                Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.

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                                Clusteri

                                ID of the expression cluster of the neighboring gene.

                                Read more
                                DCN Decorin 0.9898 46
                                CACNA1D Calcium voltage-gated channel subunit alpha1 D 0.9867 46
                                PPM1E Protein phosphatase, Mg2+/Mn2+ dependent 1E 0.9835 46
                                TIMM22 Translocase of inner mitochondrial membrane 22 0.9706 46
                                OOSP2 Oocyte secreted protein 2 0.9706 46
                                L34079.1 Novel protein 0.9693 46
                                SLC26A5 Solute carrier family 26 member 5 0.9693 46
                                FNBP1L Formin binding protein 1 like 0.9680 46
                                IL17B Interleukin 17B 0.9675 46
                                HTR1F 5-hydroxytryptamine receptor 1F 0.9666 46
                                Z84488.1 Novel protein 0.9595 46
                                TRIM49D1 Tripartite motif containing 49D1 0.9591 46
                                ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase 2 0.9542 46
                                CYP11A1 Cytochrome P450 family 11 subfamily A member 1 0.9524 46
                                TRIM49D2 Tripartite motif containing 49D2 0.9484 46

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