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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:392.1 nTPM
HPA:392.1 nTPM
GTEx:462.6 nTPM
FANTOM5:254.4 Scaled Tags Per Million
Pig:147.6 nTPM
Mouse:401.2 nTPM
Allen mouse:12.0 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 392.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 340.0
1827 Male, age 72, unknown 362.9
1870 Female, age 42, unknown 356.3
2219 Male, age 76, both hemispheres 355.6
2411 Female, age 72, unknown 353.7
1833 Male, age 53, unknown 350.2
2666 Male, age 74, left hemisphere 334.0
1830 Male, age 51, unknown 331.7
2586 Male, age 75, left hemisphere 329.8
2828 Female, age 72, unknown 324.5
2019 Male, age 18, unknown 301.1
Dorsal raphe nucleus
nTPM: 358.2
2047 Male, age 72, unknown 378.5
2298 Female, age 72, unknown 369.2
1828 Male, age 53, unknown 359.1
2750 Male, age 76, both hemispheres 353.5
2016 Female, age 72, unknown 330.7
Inferior colliculus
nTPM: 354.3
2849 Male, age 72, unknown 371.7
1848 Female, age 42, unknown 353.6
2097 Female, age 72, unknown 351.0
1890 Male, age 53, unknown 340.9
Median raphe nucleus
nTPM: 392.1
2220 Male, age 76, midline 392.1
Pedunculopontine tegmental nucleus
nTPM: 360.0
2334 Male, age 80, both hemispheres 382.2
1921 Female, age 85, both hemispheres 362.2
2338 Male, age 61, both hemispheres 335.6
Periaquaductal grey, anterior
nTPM: 353.3
1947 Male, age 18, unknown 387.2
1795 Male, age 51, unknown 343.9
2502 Female, age 75, unknown 328.7
Periaquaductal grey, dorsal
nTPM: 354.0
1840 Male, age 53, unknown 371.5
2850 Male, age 76, both hemispheres 361.1
2464 Female, age 72, unknown 344.2
1831 Male, age 72, unknown 339.3
Periaquaductal grey, lateral
nTPM: 338.9
2140 Male, age 76, both hemispheres 346.2
2053 Male, age 18, unknown 343.5
2272 Male, age 74, both hemispheres 326.9
Pretectal area
nTPM: 343.6
2224 Female, age 72, unknown 371.2
2825 Male, age 18, unknown 370.3
2667 Female, age 75, unknown 347.3
1816 Male, age 51, unknown 346.7
1944 Female, age 72, unknown 342.4
2007 Male, age 72, unknown 338.9
1817 Female, age 42, unknown 336.6
1815 Male, age 53, unknown 335.8
2316 Male, age 76, right hemisphere 331.1
2273 Male, age 74, both hemispheres 330.8
2407 Male, age 75, both hemispheres 328.7
Red nucleus
nTPM: 329.5
1821 Female, age 72, unknown 355.3
2725 Female, age 75, unknown 352.5
1954 Female, age 42, unknown 336.7
2503 Female, age 72, unknown 333.9
2588 Male, age 74, left hemisphere 330.9
2823 Male, age 76, right hemisphere 328.9
2227 Male, age 72, unknown 328.7
2769 Male, age 72, unknown 324.9
1865 Male, age 51, unknown 323.7
1904 Male, age 53, unknown 321.1
2584 Male, age 75, left hemisphere 316.4
2785 Male, age 18, unknown 300.4
Substantia nigra
nTPM: 353.2
1916 Female, age 42, unknown 395.8
2699 Male, age 18, unknown 372.8
1851 Male, age 51, unknown 364.1
1889 Female, age 72, unknown 356.1
1941 Male, age 53, unknown 353.6
2241 Male, age 72, unknown 350.1
2590 Female, age 75, unknown 344.0
2665 Male, age 74, both hemispheres 342.4
2409 Female, age 72, unknown 330.8
2583 Male, age 75, right hemisphere 322.1
Superior colliculus
nTPM: 335.6
1895 Male, age 76, right hemisphere 355.7
1839 Male, age 51, unknown 348.4
2261 Male, age 18, unknown 344.1
1796 Male, age 53, unknown 340.1
2587 Male, age 74, left hemisphere 340.1
2668 Female, age 75, unknown 335.3
2664 Male, age 75, both hemispheres 333.1
2087 Female, age 72, unknown 329.7
1913 Female, age 42, unknown 320.8
1995 Male, age 72, unknown 308.3
Ventral tegmental area
nTPM: 361.2
1915 Female, age 42, unknown 385.7
2218 Male, age 76, both hemispheres 375.2
2410 Female, age 72, unknown 354.5
2021 Male, age 53, unknown 351.0
2223 Female, age 72, unknown 351.0
1942 Male, age 51, unknown 349.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 462.6
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 462.6
Samples: 139

Max nTPM: 1023.7
Min nTPM: 228.7
Std nTPM: 131.8
Median nTPM: 448.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1023.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 896.9
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 798.1
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 796.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 735.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 716.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 702.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 700.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 675.6
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 657.7
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 657.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 657.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 652.4
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 639.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 633.0
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 617.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 616.7
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 598.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 584.2
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 580.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 580.2
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 579.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 579.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 576.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 576.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 575.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 572.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 565.2
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 561.6
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 558.4
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 543.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 541.9
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 537.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 535.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 531.9
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 525.4
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 525.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 523.8
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 517.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 517.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 512.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 509.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 506.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 502.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 502.4
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 500.1
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 499.9
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 495.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 494.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 493.9
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 493.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 489.7
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 487.0
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 483.2
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 482.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 479.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 478.1
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 477.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 472.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 471.9
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 470.5
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 468.1
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 464.7
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 464.4
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 463.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 459.9
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 455.9
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 454.9
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 450.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 448.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 447.2
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 446.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 441.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 439.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 437.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 425.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 424.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 422.3
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 419.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 416.7
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 416.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 412.2
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 409.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 407.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 406.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 404.4
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 399.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 397.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 397.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 397.3
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 392.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 390.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 389.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 387.0
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 385.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 385.0
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 384.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 382.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 382.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 380.8
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 380.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 378.5
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 378.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 377.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 372.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 368.4
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 366.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 362.6
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 362.6
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 359.6
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 357.6
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 357.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 356.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 354.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 334.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 334.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 333.1
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 330.6
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 325.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 321.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 321.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 318.8
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 318.2
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 315.4
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 312.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 311.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 307.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 305.8
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 303.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 298.6
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 297.3
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 291.6
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 291.0
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 285.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 278.4
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 263.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 263.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 255.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 228.7
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 254.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 254.4
FF:10158-103A5 76 years, female 254.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 147.6
Pig sample Sample description nTPM
Midbrain
nTPM: 147.6
Samples: 4

Max nTPM: 166.7
Min nTPM: 120.3
Sample A Female 120.3
Sample B Female 138.9
Sample C Male 166.7
Sample D Male 164.4
Periaqueductal gray
nTPM: 145.8
Samples: 3

Max nTPM: 182.0
Min nTPM: 122.7
Sample B Female 132.6
Sample C Male 182.0
Sample D Male 122.7
Substantia nigra
nTPM: 138.4
Samples: 4

Max nTPM: 213.5
Min nTPM: 60.9
Sample A Female 213.5
Sample B Female 105.7
Sample C Male 173.5
Sample D Male 60.9
Superior colliculi
nTPM: 144.3
Samples: 4

Max nTPM: 183.8
Min nTPM: 96.3
Sample A Female 183.8
Sample B Female 96.3
Sample C Male 161.0
Sample D Male 136.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 401.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 401.2
Samples: 4

Max nTPM: 413.8
Min nTPM: 372.0
Sample A Male 413.8
Sample B Male 408.4
Sample C Female 372.0
Sample D Female 410.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 12.0
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 12.0
1786 Antisense, RP_040526_02_H04, Mouse strain C57BL/6J (56 days, male) 12.0
1787 Antisense, RP_040526_02_H04, Mouse strain C57BL/6J (56 days, male) 11.5

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