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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:349.4 nTPM
HPA:349.4 nTPM
GTEx:315.9 nTPM
FANTOM5:307.8 Scaled Tags Per Million
Pig:10.0 nTPM
Mouse:10.5 nTPM
Allen mouse:0.0 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 349.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 292.1
1830 Male, age 51, unknown 355.1
1833 Male, age 53, unknown 329.9
2411 Female, age 72, unknown 329.1
1870 Female, age 42, unknown 298.7
2019 Male, age 18, unknown 297.7
2586 Male, age 75, left hemisphere 272.7
2666 Male, age 74, left hemisphere 270.8
2828 Female, age 72, unknown 264.3
2219 Male, age 76, both hemispheres 255.2
1827 Male, age 72, unknown 247.7
Dorsal raphe nucleus
nTPM: 243.5
2750 Male, age 76, both hemispheres 346.8
2016 Female, age 72, unknown 239.9
1828 Male, age 53, unknown 236.0
2047 Male, age 72, unknown 203.8
2298 Female, age 72, unknown 190.9
Inferior colliculus
nTPM: 241.4
2849 Male, age 72, unknown 283.7
1848 Female, age 42, unknown 239.8
1890 Male, age 53, unknown 234.6
2097 Female, age 72, unknown 207.6
Median raphe nucleus
nTPM: 224.2
2220 Male, age 76, midline 224.2
Pedunculopontine tegmental nucleus
nTPM: 270.7
2338 Male, age 61, both hemispheres 278.4
2334 Male, age 80, both hemispheres 271.0
1921 Female, age 85, both hemispheres 262.7
Periaquaductal grey, anterior
nTPM: 223.1
1947 Male, age 18, unknown 237.7
1795 Male, age 51, unknown 223.6
2502 Female, age 75, unknown 208.0
Periaquaductal grey, dorsal
nTPM: 216.5
2464 Female, age 72, unknown 290.0
1831 Male, age 72, unknown 210.8
2850 Male, age 76, both hemispheres 183.8
1840 Male, age 53, unknown 181.2
Periaquaductal grey, lateral
nTPM: 232.1
2272 Male, age 74, both hemispheres 259.9
2053 Male, age 18, unknown 240.7
2140 Male, age 76, both hemispheres 195.6
Pretectal area
nTPM: 236.1
2316 Male, age 76, right hemisphere 334.5
2407 Male, age 75, both hemispheres 293.9
1815 Male, age 53, unknown 274.6
2825 Male, age 18, unknown 251.8
1817 Female, age 42, unknown 222.5
2224 Female, age 72, unknown 216.1
2273 Male, age 74, both hemispheres 214.5
2007 Male, age 72, unknown 214.0
2667 Female, age 75, unknown 211.4
1816 Male, age 51, unknown 182.8
1944 Female, age 72, unknown 181.4
Red nucleus
nTPM: 349.4
2823 Male, age 76, right hemisphere 460.3
1904 Male, age 53, unknown 378.6
2769 Male, age 72, unknown 377.4
2588 Male, age 74, left hemisphere 376.5
1865 Male, age 51, unknown 375.0
2227 Male, age 72, unknown 373.5
2503 Female, age 72, unknown 354.0
1821 Female, age 72, unknown 338.3
2785 Male, age 18, unknown 329.6
1954 Female, age 42, unknown 286.3
2584 Male, age 75, left hemisphere 277.4
2725 Female, age 75, unknown 265.5
Substantia nigra
nTPM: 236.0
2590 Female, age 75, unknown 296.5
2583 Male, age 75, right hemisphere 286.8
2409 Female, age 72, unknown 276.3
2699 Male, age 18, unknown 246.6
1851 Male, age 51, unknown 231.9
1889 Female, age 72, unknown 228.4
1941 Male, age 53, unknown 210.1
2665 Male, age 74, both hemispheres 209.4
2241 Male, age 72, unknown 205.0
1916 Female, age 42, unknown 169.3
Superior colliculus
nTPM: 274.5
1913 Female, age 42, unknown 341.5
1995 Male, age 72, unknown 325.9
1895 Male, age 76, right hemisphere 324.5
2668 Female, age 75, unknown 309.5
1839 Male, age 51, unknown 292.1
2587 Male, age 74, left hemisphere 278.4
1796 Male, age 53, unknown 237.1
2664 Male, age 75, both hemispheres 226.9
2087 Female, age 72, unknown 208.0
2261 Male, age 18, unknown 201.2
Ventral tegmental area
nTPM: 243.4
2410 Female, age 72, unknown 282.0
2223 Female, age 72, unknown 272.5
2021 Male, age 53, unknown 248.1
1942 Male, age 51, unknown 226.7
2218 Male, age 76, both hemispheres 223.4
1915 Female, age 42, unknown 207.9

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 315.9
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 315.9
Samples: 139

Max nTPM: 1262.0
Min nTPM: 31.6
Std nTPM: 200.8
Median nTPM: 280.7
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1262.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 1055.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 890.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 832.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 760.9
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 671.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 656.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 647.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 608.7
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 606.8
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 593.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 577.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 574.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 558.5
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 545.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 545.1
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 540.9
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 535.1
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 534.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 534.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 520.5
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 512.5
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 509.0
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 507.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 504.6
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 502.0
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 484.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 482.5
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 476.6
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 467.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 456.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 418.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 409.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 409.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 398.6
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 397.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 384.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 381.6
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 381.4
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 379.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 379.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 376.4
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 374.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 372.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 369.0
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 368.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 361.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 353.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 353.0
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 349.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 345.6
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 341.6
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 337.4
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 334.8
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 334.4
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 329.9
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 322.8
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 313.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 305.9
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 304.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 303.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 300.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 299.9
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 292.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 289.5
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 287.0
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 286.3
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 285.7
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 281.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 280.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 278.5
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 276.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 276.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 266.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 262.7
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 261.4
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 261.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 259.3
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 258.3
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 254.9
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 248.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 244.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 234.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 233.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 232.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 228.7
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 227.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 225.0
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 221.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 215.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 212.2
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 209.0
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 206.5
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 202.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 201.1
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 198.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 189.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 187.0
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 186.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 185.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 185.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 183.4
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 183.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 178.7
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 166.3
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 161.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 156.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 156.2
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 155.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 154.6
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 154.0
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 150.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 146.4
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 144.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 142.7
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 141.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 138.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 134.6
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 129.1
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 128.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 123.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 120.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 110.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 108.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 103.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 101.6
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 99.5
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 88.5
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 85.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 85.3
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 81.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 71.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 66.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 64.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 60.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 49.0
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 37.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 36.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 31.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 307.8
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 307.8
FF:10158-103A5 76 years, female 307.8

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 10.0
Pig sample Sample description nTPM
Midbrain
nTPM: 8.8
Samples: 4

Max nTPM: 10.1
Min nTPM: 5.6
Sample A Female 9.7
Sample B Female 10.1
Sample C Male 5.6
Sample D Male 9.9
Periaqueductal gray
nTPM: 7.3
Samples: 3

Max nTPM: 8.0
Min nTPM: 6.3
Sample B Female 8.0
Sample C Male 6.3
Sample D Male 7.6
Substantia nigra
nTPM: 10.1
Samples: 4

Max nTPM: 16.9
Min nTPM: 7.2
Sample A Female 7.2
Sample B Female 7.9
Sample C Male 8.2
Sample D Male 16.9
Superior colliculi
nTPM: 7.7
Samples: 4

Max nTPM: 10.9
Min nTPM: 4.0
Sample A Female 7.3
Sample B Female 4.0
Sample C Male 8.4
Sample D Male 10.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 10.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 10.5
Samples: 4

Max nTPM: 11.0
Min nTPM: 9.3
Sample A Male 9.3
Sample B Male 11.0
Sample C Female 10.7
Sample D Female 10.8

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.0
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.0
69540733 Antisense, RP_050426_02_C12, Mouse strain C57BL/6J (56 days, male) 0.0

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