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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:769.6 nTPM
HPA:769.6 nTPM
GTEx:608.3 nTPM
FANTOM5:651.4 Scaled Tags Per Million
Pig:483.1 nTPM
Mouse:590.9 nTPM
Allen mouse:22.9 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 769.6
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 743.0
2586 Male, age 75, left hemisphere 823.4
2828 Female, age 72, unknown 766.5
2666 Male, age 74, left hemisphere 761.0
1827 Male, age 72, unknown 735.3
2219 Male, age 76, both hemispheres 735.1
2411 Female, age 72, unknown 729.7
1870 Female, age 42, unknown 726.5
2019 Male, age 18, unknown 721.9
1833 Male, age 53, unknown 719.5
1830 Male, age 51, unknown 711.0
Dorsal raphe nucleus
nTPM: 716.1
2750 Male, age 76, both hemispheres 724.6
2016 Female, age 72, unknown 719.3
1828 Male, age 53, unknown 715.0
2298 Female, age 72, unknown 710.8
2047 Male, age 72, unknown 710.5
Inferior colliculus
nTPM: 726.6
1848 Female, age 42, unknown 751.7
2849 Male, age 72, unknown 723.1
1890 Male, age 53, unknown 721.8
2097 Female, age 72, unknown 709.7
Median raphe nucleus
nTPM: 698.3
2220 Male, age 76, midline 698.3
Pedunculopontine tegmental nucleus
nTPM: 718.8
2334 Male, age 80, both hemispheres 732.1
2338 Male, age 61, both hemispheres 722.1
1921 Female, age 85, both hemispheres 702.3
Periaquaductal grey, anterior
nTPM: 769.6
2502 Female, age 75, unknown 806.9
1947 Male, age 18, unknown 754.5
1795 Male, age 51, unknown 747.3
Periaquaductal grey, dorsal
nTPM: 689.1
1840 Male, age 53, unknown 720.8
2464 Female, age 72, unknown 706.2
1831 Male, age 72, unknown 686.1
2850 Male, age 76, both hemispheres 643.4
Periaquaductal grey, lateral
nTPM: 687.6
2272 Male, age 74, both hemispheres 709.8
2053 Male, age 18, unknown 709.6
2140 Male, age 76, both hemispheres 643.4
Pretectal area
nTPM: 715.7
1816 Male, age 51, unknown 750.7
1817 Female, age 42, unknown 745.6
2007 Male, age 72, unknown 741.6
1944 Female, age 72, unknown 728.3
1815 Male, age 53, unknown 719.1
2825 Male, age 18, unknown 715.1
2407 Male, age 75, both hemispheres 714.7
2667 Female, age 75, unknown 712.9
2224 Female, age 72, unknown 686.4
2273 Male, age 74, both hemispheres 683.6
2316 Male, age 76, right hemisphere 675.2
Red nucleus
nTPM: 741.4
2584 Male, age 75, left hemisphere 785.9
2503 Female, age 72, unknown 777.3
2769 Male, age 72, unknown 751.8
2227 Male, age 72, unknown 751.3
2588 Male, age 74, left hemisphere 748.6
1821 Female, age 72, unknown 744.4
1865 Male, age 51, unknown 742.8
1904 Male, age 53, unknown 736.3
2785 Male, age 18, unknown 735.2
1954 Female, age 42, unknown 726.5
2725 Female, age 75, unknown 701.6
2823 Male, age 76, right hemisphere 695.0
Substantia nigra
nTPM: 759.7
1916 Female, age 42, unknown 827.6
2665 Male, age 74, both hemispheres 796.2
1851 Male, age 51, unknown 791.3
2590 Female, age 75, unknown 763.4
2583 Male, age 75, right hemisphere 754.5
1941 Male, age 53, unknown 749.3
2241 Male, age 72, unknown 749.0
2699 Male, age 18, unknown 748.1
1889 Female, age 72, unknown 730.0
2409 Female, age 72, unknown 687.3
Superior colliculus
nTPM: 739.1
2664 Male, age 75, both hemispheres 787.7
1796 Male, age 53, unknown 764.8
2261 Male, age 18, unknown 757.9
2668 Female, age 75, unknown 742.8
2087 Female, age 72, unknown 741.1
2587 Male, age 74, left hemisphere 738.2
1839 Male, age 51, unknown 727.0
1913 Female, age 42, unknown 718.9
1995 Male, age 72, unknown 714.3
1895 Male, age 76, right hemisphere 698.5
Ventral tegmental area
nTPM: 745.6
2410 Female, age 72, unknown 770.3
1915 Female, age 42, unknown 757.5
2223 Female, age 72, unknown 746.4
2218 Male, age 76, both hemispheres 742.3
1942 Male, age 51, unknown 738.8
2021 Male, age 53, unknown 718.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 608.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 608.3
Samples: 139

Max nTPM: 1263.1
Min nTPM: 284.5
Std nTPM: 133.6
Median nTPM: 602.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 1263.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1074.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 973.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 912.2
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 859.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 849.9
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 838.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 817.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 786.8
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 777.8
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 776.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 771.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 765.7
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 755.7
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 738.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 732.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 727.2
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 719.8
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 717.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 716.7
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 716.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 716.0
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 714.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 710.1
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 707.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 707.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 705.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 696.3
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 696.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 690.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 686.9
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 682.5
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 681.7
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 673.9
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 673.3
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 672.9
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 670.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 664.6
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 664.3
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 663.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 663.1
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 657.9
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 654.6
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 653.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 651.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 650.4
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 648.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 643.3
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 641.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 638.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 637.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 637.1
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 635.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 632.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 625.7
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 624.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 621.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 621.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 619.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 616.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 616.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 616.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 616.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 615.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 610.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 609.0
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 605.6
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 605.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 604.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 602.8
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 600.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 598.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 597.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 593.4
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 592.0
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 592.0
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 590.8
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 588.8
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 585.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 583.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 582.6
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 579.8
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 578.6
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 578.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 578.4
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 575.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 569.7
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 569.6
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 568.4
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 565.9
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 565.4
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 562.6
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 560.1
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 558.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 552.9
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 552.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 549.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 547.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 546.0
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 540.6
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 538.8
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 536.1
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 528.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 528.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 525.6
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 524.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 519.8
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 514.4
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 510.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 509.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 509.0
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 507.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 507.0
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 496.9
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 496.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 495.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 494.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 490.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 479.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 475.1
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 467.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 463.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 462.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 456.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 450.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 440.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 439.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 436.1
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 435.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 430.3
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 429.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 428.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 421.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 419.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 381.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 372.1
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 369.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 330.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 284.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 651.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 651.4
FF:10158-103A5 76 years, female 651.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 483.1
Pig sample Sample description nTPM
Midbrain
nTPM: 435.6
Samples: 4

Max nTPM: 492.2
Min nTPM: 374.1
Sample A Female 492.2
Sample B Female 374.1
Sample C Male 477.2
Sample D Male 398.8
Periaqueductal gray
nTPM: 313.8
Samples: 3

Max nTPM: 339.9
Min nTPM: 263.0
Sample B Female 338.4
Sample C Male 339.9
Sample D Male 263.0
Substantia nigra
nTPM: 400.4
Samples: 4

Max nTPM: 467.8
Min nTPM: 354.1
Sample A Female 467.8
Sample B Female 371.1
Sample C Male 408.4
Sample D Male 354.1
Superior colliculi
nTPM: 483.1
Samples: 4

Max nTPM: 513.1
Min nTPM: 452.6
Sample A Female 513.1
Sample B Female 498.1
Sample C Male 468.7
Sample D Male 452.6

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 590.9
Mouse sample Sample description nTPM
Midbrain
nTPM: 590.9
Samples: 4

Max nTPM: 663.9
Min nTPM: 551.0
Sample A Male 663.9
Sample B Male 551.0
Sample C Female 555.5
Sample D Female 593.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 22.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 22.9
308055136 Antisense, RP_140710_01_A05, Mouse strain C57BL/6J (56 days, male) 25.2
67936204 Antisense, RP_041102_01_B02, Mouse strain C57BL/6J (56 days, male) 20.6

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