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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:130.8 nTPM
HPA:130.8 nTPM
GTEx:153.3 nTPM
FANTOM5:426.1 Scaled Tags Per Million
Pig:146.1 nTPM
Mouse:57.0 nTPM
Allen mouse:2.9 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 130.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 100.1
2411 Female, age 72, unknown 124.7
2019 Male, age 18, unknown 123.1
1870 Female, age 42, unknown 122.2
1830 Male, age 51, unknown 121.4
1833 Male, age 53, unknown 115.5
2828 Female, age 72, unknown 96.5
2219 Male, age 76, both hemispheres 80.7
2666 Male, age 74, left hemisphere 78.6
1827 Male, age 72, unknown 75.6
2586 Male, age 75, left hemisphere 62.9
Dorsal raphe nucleus
nTPM: 84.0
2750 Male, age 76, both hemispheres 133.0
1828 Male, age 53, unknown 84.0
2016 Female, age 72, unknown 77.2
2047 Male, age 72, unknown 66.9
2298 Female, age 72, unknown 58.9
Inferior colliculus
nTPM: 75.9
1890 Male, age 53, unknown 85.3
1848 Female, age 42, unknown 77.9
2849 Male, age 72, unknown 73.9
2097 Female, age 72, unknown 66.7
Median raphe nucleus
nTPM: 87.0
2220 Male, age 76, midline 87.0
Pedunculopontine tegmental nucleus
nTPM: 103.1
2338 Male, age 61, both hemispheres 114.9
2334 Male, age 80, both hemispheres 105.2
1921 Female, age 85, both hemispheres 89.3
Periaquaductal grey, anterior
nTPM: 60.8
1947 Male, age 18, unknown 65.6
1795 Male, age 51, unknown 58.9
2502 Female, age 75, unknown 57.8
Periaquaductal grey, dorsal
nTPM: 60.5
2464 Female, age 72, unknown 73.7
1831 Male, age 72, unknown 66.0
2850 Male, age 76, both hemispheres 51.9
1840 Male, age 53, unknown 50.3
Periaquaductal grey, lateral
nTPM: 64.5
2272 Male, age 74, both hemispheres 74.1
2053 Male, age 18, unknown 67.7
2140 Male, age 76, both hemispheres 51.8
Pretectal area
nTPM: 70.7
1815 Male, age 53, unknown 83.6
2407 Male, age 75, both hemispheres 80.3
2316 Male, age 76, right hemisphere 80.1
1817 Female, age 42, unknown 76.1
2007 Male, age 72, unknown 74.4
2273 Male, age 74, both hemispheres 72.1
2825 Male, age 18, unknown 70.8
2224 Female, age 72, unknown 63.3
1944 Female, age 72, unknown 61.3
2667 Female, age 75, unknown 60.2
1816 Male, age 51, unknown 55.2
Red nucleus
nTPM: 130.8
1821 Female, age 72, unknown 161.0
2823 Male, age 76, right hemisphere 156.9
1865 Male, age 51, unknown 153.9
1904 Male, age 53, unknown 140.0
2769 Male, age 72, unknown 134.3
2227 Male, age 72, unknown 132.2
2785 Male, age 18, unknown 131.2
1954 Female, age 42, unknown 121.3
2503 Female, age 72, unknown 118.2
2725 Female, age 75, unknown 115.8
2588 Male, age 74, left hemisphere 105.9
2584 Male, age 75, left hemisphere 99.4
Substantia nigra
nTPM: 79.4
1889 Female, age 72, unknown 96.3
2583 Male, age 75, right hemisphere 93.4
2590 Female, age 75, unknown 91.1
1851 Male, age 51, unknown 87.0
1941 Male, age 53, unknown 79.5
2409 Female, age 72, unknown 77.8
1916 Female, age 42, unknown 72.0
2699 Male, age 18, unknown 71.2
2241 Male, age 72, unknown 66.7
2665 Male, age 74, both hemispheres 59.2
Superior colliculus
nTPM: 85.1
1913 Female, age 42, unknown 113.6
1995 Male, age 72, unknown 107.2
2587 Male, age 74, left hemisphere 100.4
1895 Male, age 76, right hemisphere 98.7
2668 Female, age 75, unknown 97.0
1839 Male, age 51, unknown 83.7
1796 Male, age 53, unknown 70.5
2087 Female, age 72, unknown 65.6
2261 Male, age 18, unknown 58.8
2664 Male, age 75, both hemispheres 55.5
Ventral tegmental area
nTPM: 98.7
2223 Female, age 72, unknown 159.5
2410 Female, age 72, unknown 109.2
2218 Male, age 76, both hemispheres 91.7
1942 Male, age 51, unknown 82.6
1915 Female, age 42, unknown 75.4
2021 Male, age 53, unknown 73.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 153.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 153.3
Samples: 139

Max nTPM: 888.5
Min nTPM: 21.3
Std nTPM: 120.2
Median nTPM: 122.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 888.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 641.6
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 583.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 480.8
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 480.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 415.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 359.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 341.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 329.1
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 316.0
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 305.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 291.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 279.7
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 271.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 266.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 257.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 254.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 252.9
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 239.6
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 237.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 234.8
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 233.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 228.8
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 215.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 215.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 211.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 211.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 204.3
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 196.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 196.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 193.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 192.8
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 192.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 190.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 186.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 184.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 182.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 180.6
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 180.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 174.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 174.4
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 172.4
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 172.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 171.8
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 171.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 171.1
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 166.5
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 163.2
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 160.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 159.7
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 158.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 152.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 149.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 148.5
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 145.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 143.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 142.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 141.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 141.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 136.2
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 135.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 132.3
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 131.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 130.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 127.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 124.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 123.8
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 123.1
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 122.4
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 122.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 121.1
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 120.0
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 119.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 119.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 119.1
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 114.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 111.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 111.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 110.0
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 109.6
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 108.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 107.6
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 107.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 104.7
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 103.7
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 101.4
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 101.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 100.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 99.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 93.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 93.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 92.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 91.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 91.0
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 90.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 90.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 88.0
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 86.7
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 86.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 85.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 84.9
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 84.2
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 83.2
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 81.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 81.4
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 79.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 78.7
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 78.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 77.1
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 72.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 69.9
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 69.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 68.1
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 67.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 66.8
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 65.7
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 65.2
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 64.9
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 62.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 62.7
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 60.4
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 57.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 56.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 55.1
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 54.7
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 53.8
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 52.1
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 51.6
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 48.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 48.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 48.0
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 47.4
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 38.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 36.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 34.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 31.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 30.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 23.0
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 21.3
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 426.1
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 426.1
FF:10158-103A5 76 years, female 426.1

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 146.1
Pig sample Sample description nTPM
Midbrain
nTPM: 146.1
Samples: 4

Max nTPM: 513.7
Min nTPM: 13.7
Sample A Female 513.7
Sample B Female 27.9
Sample C Male 28.9
Sample D Male 13.7
Periaqueductal gray
nTPM: 19.2
Samples: 3

Max nTPM: 27.0
Min nTPM: 11.2
Sample B Female 19.5
Sample C Male 11.2
Sample D Male 27.0
Substantia nigra
nTPM: 72.4
Samples: 4

Max nTPM: 128.2
Min nTPM: 16.8
Sample A Female 84.9
Sample B Female 16.8
Sample C Male 59.7
Sample D Male 128.2
Superior colliculi
nTPM: 44.5
Samples: 4

Max nTPM: 61.1
Min nTPM: 22.9
Sample A Female 40.4
Sample B Female 22.9
Sample C Male 61.1
Sample D Male 53.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 57.0
Mouse sample Sample description nTPM
Midbrain
nTPM: 57.0
Samples: 4

Max nTPM: 63.5
Min nTPM: 49.5
Sample A Male 61.8
Sample B Male 53.3
Sample C Female 49.5
Sample D Female 63.5

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.9
70565129 Antisense, RP_050623_04_C08, Mouse strain C57BL/6J (56 days, male) 4.4
74988616 Antisense, RP_060315_05_F09, Mouse strain C57BL/6J (56 days, male) 1.4

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